Colorado Rockies vs San Francisco Giants Prediction, 9/26/2025 MLB Picks, Best Bets & Odds

Game: Colorado Rockies vs San Francisco Giants

Date: Friday, September 26, 2025

Location: Oracle Park in San Francisco, CA

TV: NBC Bay Area

Odds/Point Spread: Colorado (+126) San Francisco (-152)

Oracle Park is the location where the San Francisco Giants (78-81) will go up against the Colorado Rockies (43-115) on Friday. The moneyline on this contest has the Rockies at +126 while the Giants are sitting at -152. The total is 8.5. The starting pitchers will be German Marquez and Kai-Wei Teng.

As a team, the Colorado Rockies are putting up 3.7 runs per game, which is 29th in the league. They have a total of 589 runs while holding a team on-base percentage of .294. The Rockies have recorded 248 doubles as a squad and have hit 156 baseballs out of the park. They have amassed 573 RBI's as well as 1,255 hits so far this season, and their batting average comes in at .238. Colorado has a slugging percentage of .387 and have been called out on strikes 1,484 times, while drawing a walk on 387 occasions.

Get all of our Free MLB Picks

The Rockies have an earned run average of 5.99 so far this season (30th in the league), and the staff has struck out 1,070 batters. Rockies pitchers have conceded 245 long balls in addition to 1,001 total runs (30th in the league). Their pitching staff has walked 535 opposing batters and their FIP is 5.22 as a team this year. Colorado has yielded 1,645 base hits (10.8 per 9 innings) in addition to 915 earned runs. They have accumulated a K/BB ratio of 2.00 and their pitching staff has earned a collective WHIP of 1.59.

Rockies relief pitchers have entered the game with players on base 158 times and also have had 139 appearances in high leverage situations. The relievers are sitting with 61 holds for the year (30th in baseball). The Rockies bullpen have compiled a save rate of 53.7% and stepped onto the hill in 115 save situations. They have tallied 29 saves this season and have missed out on 25 out of their 54 chances to save the game. The relievers have inherited 271 base runners for the season with 35.8% of them ended up scoring. The Rockies have sent 518 relievers to the hill this season.

The Cleveland Guardians have accounted for 4,126 putouts so far this season, as well as 1,437 assists and 109 errors. Their fielding rate is at .981 which has them ranked 29th in MLB, and have a total of 154 double plays. The Rockies have converted 65.8% of baseballs in play into outs out of their 12,378 innings, which has them ranked 30th in the majors.

Marquez (68-71 career win-loss mark) has a FIP of 4.57 and he has gone up against 4,885 batters during his time in the majors. He has allowed 1,170 base hits (9.2 hits per nine innings) with 351 free passes. His ERA is 4.64 (589 earned runs allowed) and his career WHIP is 1.332. Marquez has thrown 1,142 innings and has 1,068 strikeouts in his MLB career.

The San Francisco Giants hold a team on-base percentage of .311 as well as a batting average of .235 over the course of the season. They have struck out on 1,363 occasions (11th in baseball) and have accounted for 1,243 hits. San Francisco has a total of 168 home runs on the campaign as well as 658 RBIs. The Giants have a slugging percentage of .385 and they are recording 4.35 runs per contest (17th in MLB). They have recorded 236 doubles, while walking 543 times and putting up 691 runs.

The Giants have a WHIP of 1.306 with a FIP of 3.76 as a pitching staff so far this season. They rank 21st in MLB as a pitching staff in total hits given up with 1,336. The San Francisco pitching staff have surrendered 678 runs on the year while holding a team ERA of 3.88 (606 earned runs surrendered). They currently have a strikeout to walk ratio of 8.50 (1,324 strikeouts against 501 free passes). They have allowed 139 home runs and they give up 4.34 runs per 9 innings (16th in the league).

San Francisco has called on relievers to take the mound in 60 save opportunities and they have earned 38 saves. They are currently ranked 16th in MLB holding a save percentage of 63.3%, and they have sent 506 bullpen pitchers to the mound on the year. Their relief pitchers have stepped onto the hill 170 times in high leverage situations and also on 121 occasions with base runners. San Francisco bullpen pitchers have an inherited score percentage of 37.2% out of 191 inherited runners. With 143 save situations, the Giants have compiled 83 holds and also 22 blown saves.

The San Francisco Giants have turned 132 double plays and have a fielding percentage of .984 (24th in MLB). The Giants have racked up 1,498 assists, 93 errors and have notched a total of 4,220 putouts over the course of the season. In 12,660 innings on the field, the Giants are sitting with a defensive efficiency of 68.3% (27th in baseball).

So far in his MLB career, Teng has given up 44 base knocks while tallying 46 strikeouts in 40 innings. He has surrendered a total of 33 ER's while holding a WHIP of 1.716 and a FIP of 7.3. He has a K/BB ratio of 1.84 and he has faced 194 batters thus far in his career. Teng (2-4 career record) has a 7.39 ERA and has conceded 9.9 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Colorado (+126)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here