Houston Astros vs Toronto Blue Jays Prediction, 9/10/2025 MLB Picks, Best Bets & Odds

Game: Houston Astros vs Toronto Blue Jays

Date: Wednesday, September 10, 2025

Location: Rogers Centre in Toronto, ON

TV: Sportsnet

Odds/Point Spread: Houston (+126) Toronto (-152)

Rogers Centre is the site where the Toronto Blue Jays (82-61) will play the Houston Astros (78-66) on Wednesday. The odds on this game have the Astros at +126 and the Blue Jays are at -152. The over/under has been set at 8.5. The expected starting pitchers are Jason Alexander and Jose Berrios.

The Astros have tallied 222 two-baggers as a unit and have hit 159 baseballs out of the park. Houston is slugging .401 and have been called out on strikes 1,147 times, while taking a walk on 426 occasions. As a team, the Houston Astros are notching 4.2 runs per game, which puts them at 25th in MLB. They have earned 581 runs batted in as well as 1,234 hits so far this year, and their average at the plate is at .253. They have tallied 609 runs scored and have an on-base percentage of .318.

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The Astros are sitting with a team ERA of 3.85 on the campaign (8th in the league), and the staff has rung up 1,365 hitters. Astros pitchers have allowed 175 long balls and also 590 runs (8th in the league). Their pitching staff has walked 454 opposing players and their FIP comes in at 3.98 as a unit over the course of the season. Houston has surrendered 1,114 base hits (7.8 per 9 innings) in addition to 550 earned runs. They have earned a K/BB ratio of 3.01 and the pitching staff has a team WHIP of 1.22.

Astros bullpen pitchers have entered the game with opponents on base 112 times in addition to having 153 appearances in high leverage situations. The relief pitchers have a total of 80 holds on the year (14th in baseball). The Astros relief pitchers have accumulated a save percentage of 74.1% and have stepped onto the mound in 137 save situations. They have recorded 40 saves so far this season and have blown 14 of 54 save opportunities. The bullpen pitchers have inherited 154 runners on the year with 23.4% of those players crossed home plate. The Astros have dispatched 458 relief pitchers to the hill over the course of the season.

The Detroit Tigers have notched a total of 3,854 putouts this season, as well as 1,132 assists and 62 errors. Their fielding percentage is holding steady at .988 which has them ranked 8th in pro baseball, and have accumulated 93 double plays. The Astros have converted 70.6% of baseballs in play into outs out of their 11,562 innings, which has them sitting at 9th in pro baseball.

Alexander (6-4 career record) has earned a FIP of 5.03 while he has faced 584 hitters during his time in the major leagues. He has given up 149 hits (10.3 hits per 9 innings) with 50 walks. His earned run average is 5.11 (74 ER's allowed) and his WHIP is 1.526. Alexander has taken the mound for 130 innings and has accounted for 98 strikeouts during his MLB career.

The Blue Jays hold a slugging percentage of .433 and they score 5.00 runs per contest (4th in baseball). They have 263 two-baggers, while taking a walk 468 times as well as putting up 715 runs. Toronto has accumulated 174 home runs for the year and 690 RBIs. They have struck out on 966 instances (30th in the league) and have 1,315 hits. The Toronto Blue Jays have compiled an on-base percentage of .338 as well as a batting average of .269 over the course of the season.

The Blue Jays are sitting with a team WHIP of 1.268 in addition to having a FIP of 4.33 as a squad on the season. They are sitting at 10th in MLB as a pitching staff in total hits allowed with 1,155. The Toronto pitching staff have surrendered 650 runs so far this year while having an ERA of 4.24 (597 earned runs surrendered). Their K/BB ratio comes in at 9.00 (1,270 strikeouts vs 453 walks). They have allowed 191 dingers and they allow 4.61 runs per 9 innings (19th in MLB).

Toronto bullpen pitchers hold an inherited score percentage of 30.3% out of their 218 inherited base runners. Their relief pitchers have stepped onto the mound 142 times in high leverage situations and also on 152 occasions with runners on base. Sitting with 153 save situations, the Blue Jays have amassed 86 holds and also 23 blown saves. They are ranked 16th in MLB holding a save rate of 62.9%, and they have sent 496 bullpen pitchers onto the field for the year. Toronto has called on relievers to enter the game in 62 save opportunities and they have walked away with 39 saves.

The Toronto Blue Jays have turned 101 double plays and have a fielding percentage of .984 (24th in the majors). The Blue Jays have racked up 1,089 assists, 81 errors and have 3,804 putouts over the course of the season. Out of their 11,412 innings on the field, the Blue Jays are sitting with a defensive efficiency of 70.0% (14th in pro baseball).

During his pro baseball career, Berrios has surrendered 1,463 base hits while totaling 1,474 K's in 1,559 innings. Berrios (108-82 career record) holds a 4.07 earned run average while conceding 8.4 hits per nine innings. He has surrendered 705 earned runs while earning a WHIP of 1.238 and having a FIP of 4.0. His strikeout to walk ratio is 3.15 and he has faced 6,558 hitters during his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Houston (+126)

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