San Diego Padres vs Houston Astros Prediction, 4/20/2025 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs Houston Astros

Date: Sunday, April 20, 2025

Location: Daikin Park in Houston, TX

TV: Space City Home Network

Odds/Point Spread: San Diego (-275) Houston (+220)

The San Diego Padres (15-4) are traveling to Daikin Park on Sunday where they will try to beat the Houston Astros (8-10). The moneyline on this game has the Padres at -275 while the Astros open at +220. The over/under is set at 8.5. The pitchers who are expected to start are Dylan Cease and Framber Valdez.

San Diego has a slugging percentage of .417 and have struck out 124 times, while taking a walk on 70 occasions. They have amassed 80 runs batted in and 171 base knocks this season, while their team batting average sits at .274. The Padres have tallied 32 two-baggers as a squad and have knocked 19 baseballs out of the stadium. They have notched a total of 88 runs scored while having a team on-base percentage of .348. As a unit, the San Diego Padres are notching 4.6 runs per contest, which ranks them 10th in MLB.

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The Padres have compiled a team ERA of 2.56 this year (2nd in the league), and their staff has rung up 165 hitters. Padres pitchers have allowed 13 long balls in addition to 51 runs (1st in MLB). They have walked 64 players from the other team and their FIP sits at 3.25 as a squad on the season. San Diego has relinquished 117 hits (6.2 per 9 innings) and also 48 earned runs. They have accrued a K/BB ratio of 2.58 and the pitching staff holds a WHIP of 1.07.

The Padres have sent 65 relievers to the mound so far this year. The bullpen pitchers have inherited 22 runners for the season with 27.3% of them crossed the plate. They have accumulated 9 saves for the season and have missed out on 1 of their 10 save opportunities. The Padres bullpen have earned a save rate of 90.0% and have entered the game in 27 save situations. The relievers have a total of 17 holds this season (4th in MLB). Padres relief pitchers have entered the game with runners on base 15 times and also have had 29 appearances in high leverage situations.

The Padres have transformed 74.7% of balls hit into play into outs out of 1,521 innings on the diamond, which has them sitting at 2nd in professional baseball. The San Diego Padres have accounted for 507 putouts so far this season, as well as 140 assists and 9 errors. Their fielding rate is holding at .986 which is 14th in MLB, and they have turned 14 double plays.

Cease (58-47 career record) has a FIP of 3.76 and he has faced 3,673 opposing batters during his time in the major leagues. He has allowed 726 base hits (7.5 hits per nine innings) and has 366 walks. His ERA is 3.82 (368 ER's allowed) and he has a WHIP of 1.259. Cease has taken the hill for 867 innings and has accounted for 1,040 strikeouts in his MLB career.

Houston has tallied 14 home runs so far this season and 59 runs batted in. They have hit 16 two-baggers, while taking a walk 66 times and scoring 66 runs. The Houston Astros have recorded a team OBP of .300 as well as a batting average of .216 for the season. The Astros hold a team slugging percentage of .317 and they average 3.67 runs per contest (23rd in the league). They have been called out on strikes on 152 occasions (18th in MLB) and have tallied 127 hits.

The Astros have a team WHIP of 1.129 and have a FIP of 3.37 as a pitching staff this year. They are currently ranked 3rd in baseball as a staff in total hits surrendered with 123. The Houston pitching staff have given up 70 runs on the season and come in with a team ERA of 3.74 (67 earned runs relinquished). They currently have a K/BB ratio of 10.10 (181 strikeouts against 59 free passes). They have conceded 17 dingers and they surrender 3.91 runs per 9 innings (8th in baseball).

Houston relief pitchers have an inherited score percentage of 34.8% of 23 inherited runners. Their bullpen pitchers have taken the field 18 times in high leverage situations and on 16 occasions with runners on. With 20 save situations, the Astros have amassed 12 holds and also 3 blown saves. They rank 15th in MLB with a save rate of 62.5%, and they have sent 59 bullpen pitchers to the hill so far this season. Houston has called on relievers to step onto the hill in 8 save chances and they have earned 5 saves.

Out of their 1,455 innings on the field, the Astros have accumulated a defensive efficiency of 72.2% (8th in professional baseball). The Houston Astros have turned 9 double plays and have a fielding percentage of .986 (16th in professional baseball). The Astros have accrued 130 assists, 9 errors and have a total of 485 putouts during this campaign.

In his pro baseball career, Valdez has conceded 761 base knocks while he has earned 890 strikeouts in 910 frames. He has given up a total of 338 earned runs while holding a WHIP of 1.198 and a FIP of 3.3. His K/BB ratio is 2.71 and he has gone up against 3,775 hitters during his pro baseball career. Valdez (69-43 career win-loss record) has a 3.34 ERA while surrendering 7.5 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Houston (+220)

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