San Francisco Giants vs Chicago Cubs Prediction, 6/5/2026 MLB Picks, Best Bets & Odds

Game: San Francisco Giants vs Chicago Cubs

Date: Friday, June 5, 2026

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: San Francisco (+125) Chicago (-145)

The Chicago Cubs (32-29) will compete against the San Francisco Giants (23-38) at Wrigley Field on Friday. The line on this matchup has San Francisco at +125 while Chicago is sitting at -145. The over/under is set at 9. The starting pitchers will be Robbie Ray and Ben Brown.

The Giants have accrued 124 two-baggers as a unit and have hit 55 baseballs out of the stadium. San Francisco is slugging .404 and have been rung up 480 times, while being walked on 133 occasions. As a unit, the San Francisco Giants are earning 3.9 runs per outing, which ranks them 27th in baseball. They have earned 230 RBI's in addition to 530 hits so far this season, while their batting average is .253. They have notched a total of 237 runs while holding a team OBP of .301.

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The Giants hold a team ERA of 4.60 this season (25th in the league), and the staff has rung up 480 hitters. Giants pitchers have surrendered 62 home runs in addition to 304 runs (24th in MLB). Their pitching staff has walked 243 players from the other team and their FIP sits at 4.27 as a team over the course of the season. San Francisco has given up 518 base hits (8.7 per 9 innings) in addition to 275 earned runs. They have accumulated a K/BB ratio of 1.98 and the pitching staff sits with a WHIP of 1.42.

The Giants have dispatched 198 relievers to the hill for the year. The bullpen pitchers have inherited 93 runners this year and 31.2% of those runners earned a run for their team. The bullpen have earned 32 holds for the season (17th in baseball). Giants relief pitchers have entered the game with players on base 63 times and also have had 39 appearances in high leverage situations. They have tallied 10 saves on the year and have not converted 7 of 17 save opportunities. The Giants relief pitchers have recorded a save rate of 58.8% and have stepped onto the mound in 49 save situations.

The Giants have converted 68.5% of baseballs in play into outs out of 4,839 innings on the diamond, which has them ranked 27th in pro baseball. The San Francisco Giants have a total of 1,613 putouts on the campaign, as well as 579 assists and 42 errors. Their fielding percentage is currently at .981 which puts them in 27th in baseball, and they have turned 62 double plays.

Ray (91-87 career record) has a FIP of 3.90 while he has gone up against 6,366 opposing hitters during his time in the major leagues. He has surrendered 1,307 hits (7.8 hits per nine innings) and has had 639 walks. His earned run average is 3.96 (662 ER's allowed) and his WHIP is 1.295. Ray has taken the ball for 1,503 innings and has racked up 1,793 K's in his pro baseball career.

The Cubs have a team slugging percentage of .384 and they score 4.67 runs per game (8th in the league). They have 89 doubles, while walking 268 times and scoring 285 runs. Chicago has hit 67 home runs so far this season as well as 262 RBIs. They have been rung up on 506 occasions (14th in MLB) and have accounted for 493 base hits. The Chicago Cubs have tallied a team on-base percentage of .333 and a batting average of .238 over the course of the season.

The Cubs have a team WHIP of 1.232 and have a FIP of 4.42 as a unit so far this year. Their K/BB ratio is 8.10 (484 strikeouts vs 183 free passes). They sit at 12th in the league as a pitching staff in total hits allowed with 481. They have given up 83 home runs and they concede 4.46 runs per 9 innings (13th in baseball). The Chicago pitching staff have allowed 267 runs so far this year while having an ERA of 4.16 (249 earned runs relinquished).

With 34 save situations, the Cubs have earned 14 holds and 7 blown saves. Chicago has had bullpen pitchers enter the game in 17 save opportunities and they have earned 10 saves. Chicago relievers hold an inherited score rate of 30.8% of 78 inherited base runners. Their relievers have stepped onto the hill 53 times in high leverage situations and on 54 occasions with runners on base. They are currently ranked 20th in the league holding a save percentage of 58.8%, and they have dispatched 183 relievers to the hill for the year.

The Chicago Cubs have turned 43 double plays and hold a fielding percentage of .987 (12th in the majors). The Cubs have recorded 576 assists, 28 errors and have earned 1,618 putouts so far this year. In 4,854 innings played, the Cubs have a efficiency on defense of 71.9% (4th in baseball).

So far in his career, Brown has allowed 195 hits while accumulating 238 K's in 212 innings pitched. He has allowed a total of 103 earned runs while earning a WHIP of 1.229 and being the owner of a FIP of 4.3. His strikeout to walk ratio is 3.61 and he has faced 895 batters thus far in his career. Brown (8-13 career mark) has earned a 4.36 ERA and has surrendered 8.3 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take San Francisco (+125)

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