Tampa Bay Rays vs St. Louis Cardinals Prediction, 3/29/2026 MLB Picks, Best Bets & Odds
Game: Tampa Bay Rays vs St. Louis Cardinals
Date: Sunday, March 29, 2026
Location: Busch Stadium in St. Louis, MO
TV: Cardinals.TV
Odds/Point Spread: Tampa Bay (+220) St. Louis (-275)
The St. Louis Cardinals (78-84 last year) will go up against the Tampa Bay Rays (77-85 last season) at Busch Stadium on Sunday. The moneyline on this contest has the Rays at +220 and the Cardinals are coming in at -275. The over/under comes in at 9. The pitchers expected to start will be Steven Matz and Dustin May.

Tampa Bay had a slugging percentage of .401 and struck out 1,397 times, while being walked on 468 occasions. They had 680 runs batted in as well as 1,374 base knocks over the course of the prior season, while their average at the plate came in at .251. The Rays recorded 242 doubles as a team and smacked 182 balls out of the park. They tallied 714 runs scored and held an OBP of .313. As a unit, the Tampa Bay Rays put up 4.4 runs per contest, which was 15th in MLB.
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The Rays had an ERA of 3.94 over the course of last year (15th in the league), and the staff rung up 1,416 hitters. Rays pitchers surrendered 205 long balls and 683 runs (13th in MLB). They walked 474 opposing players and their FIP came in at 4.15 as a team over the course of last season. Tampa Bay yielded 1,273 base hits (8.0 per 9 innings) as well as 627 earned runs. Their strikeout to walk ratio was at 2.99 and their pitching staff earned a collective WHIP of 1.22.
Rays relief pitchers entered the game with players on base 112 times and also had 156 outings in high leverage situations. The bullpen notched 87 holds over the course of the prior season (18th in the league). The Rays relief pitchers recorded a save percentage of 54.7% and came into the game in 154 save situations. They recorded 35 saves in the prior season and blew 29 out of their 64 save opportunities. The relievers inherited 165 runners over the course of the prior season and 32.1% of them crossed the plate. The Rays had dispatched 518 relief pitchers to the hill in the previous season.
The Tampa Bay Rays amassed 4,294 putouts over the course of last year, in addition to 1,416 assists and 81 errors. Their fielding percentage held steady at .986 which had them ranked 15th in professional baseball, and had a total of 147 double plays. The Rays converted 70.5% of balls hit into play into outs out of their 12,882 innings on the field, which had them sitting 10th in pro baseball.
Matz (60-62 mark in his career) holds a FIP of 4.13 while facing 4,283 opposing batters in the major leagues. He has given up 1,023 base hits (9.2 hits per 9 innings) and has had 291 walks. His earned run average is 4.20 (468 earned runs allowed) and his career WHIP is 1.310. Matz has pitched in 1,003 innings and has racked up 940 K's during his career.
St. Louis recorded 148 HRs in the prior season to go along with 653 RBIs. They hit 263 two-baggers, while walking 478 times and putting up 689 runs. The St. Louis Cardinals had an on-base percentage of .314 and a team batting average of .245 over the course of last year. The Cardinals held a slugging percentage of .378 and they were recording 4.25 runs per game (19th in baseball). They were rung up on 1,321 occasions (22nd in MLB) and earned 1,331 base knocks.
The St. Louis pitching staff given up 754 runs last year while having an ERA of 4.29 (682 earned runs surrendered). They surrendered 170 long balls and they surrender 4.74 runs per 9 innings (22nd in baseball). The Cardinals finished with a team WHIP of 1.323 in addition to having a FIP of 4.06 as a squad for the prior year. Their strikeout to walk ratio came in at 7.60 (1,209 strikeouts against 461 walks). They ranked 28th in MLB as a staff in total hits given up with 1,434.
St. Louis called on bullpen pitchers to take the mound in 65 save chances and they tallied 42 saves. They ranked 12th in baseball holding a save rate of 64.6%, and they sent 487 relief pitchers to the hill last season. Their relievers stepped onto the mound 158 times in high leverage situations and on 156 occasions with base runners. St. Louis relief pitchers held an inherited score percentage of 33.6% out of their 217 inherited runners. Wrapping up the year with 161 save situations, the Cardinals accrued 92 holds and 23 blown saves.
The St. Louis Cardinals had 124 double plays and held a fielding percentage of .987 (11th in professional baseball). The Cardinals racked up 1,557 assists, 80 errors and had a total of 4,296 putouts last season. In 12,888 innings played, the Cardinals finished with a defensive efficiency of 68.9% (23rd in professional baseball).
May (19-20 career win-loss mark) holds a 3.87 ERA while allowing 7.7 hits per 9 innings. His strikeout to walk ratio is 2.63 and he has faced 1,356 opposing hitters in his career. He has conceded a total of 139 earned runs while holding a WHIP of 1.203 and a FIP of 3.8. So far in his career, May has allowed 276 hits while totaling 297 strikeouts in 323 innings pitched.
Who will win tonight's MLB game against the spread or moneyline?
Tony Sink's Pick: Take St. Louis (-275)
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Additional Resources:
St. Louis Cardinals - Twitter
Tampa Bay Rays - Twitter
