Arizona Diamondbacks vs Los Angeles Dodgers Prediction, 5/21/2025 MLB Picks, Best Bets & Odds

Game: Arizona Diamondbacks vs Los Angeles Dodgers

Date: Wednesday, May 21, 2025

Location: Dodger Stadium in Los Angeles, CA

TV: Spectrum SportsNet LA

Odds/Point Spread: Arizona (+125) Los Angeles (-150)

Dodger Stadium is the location where the Los Angeles Dodgers (29-19) will attempt to defeat the Arizona Diamondbacks (26-22) on Wednesday. The line on this matchup has the Diamondbacks at +125 and the Dodgers are priced at -150. The over/under is 9. The starting pitchers will be Corbin Burnes and Dustin May.

Arizona has a slugging rate of .452 and have struck out 356 times, while taking a walk on 187 occasions. They have accumulated 245 runs batted in in addition to 416 base knocks so far this year, and their average at the plate is .256. The Diamondbacks have tallied 99 two-baggers as a squad and have knocked 67 balls out of the park. They are sitting with 252 runs while having a team on-base percentage of .337. As a unit, the Arizona Diamondbacks are knocking in 5.3 runs per game, which ranks them 5th in MLB.

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They have earned a strikeout to walk ratio of 2.56 and their pitching staff holds a collective WHIP of 1.34. Diamondbacks pitchers have allowed 67 home runs in addition to 245 total runs (25th in baseball). Arizona has allowed 414 base hits (8.7 per 9 innings) as well as 225 earned runs. The Diamondbacks have a team earned run average of 4.71 on the season (24th in the league), and their staff has rung up 418 batters. They have walked 163 opposing hitters and their FIP comes in at 4.45 as a team on the year.

The Diamondbacks relief pitchers have accumulated a save percentage of 65.4% and have entered the game in 56 save situations. The bullpen pitchers have inherited 47 runners over the course of the season and 29.8% of those players crossed the plate. Diamondbacks pitchers have gone to the mound with runners on base 38 times as well as having 48 appearances in high leverage situations. The Diamondbacks have dispatched 145 relievers to the hill on the campaign. The relievers have notched 29 holds for the season (11th in MLB). They have recorded 17 saves so far this year and have blown 9 out of their 26 chances to save the game.

The Arizona Diamondbacks have amassed 1,290 putouts for the season, as well as 427 assists and 25 errors. Their fielding percentage is at .986 which ranks 19th in professional baseball, and they have turned 34 double plays. The Diamondbacks have converted 69.4% of baseballs in play into outs out of 3,870 innings, which has them sitting 20th in MLB.

Burnes has taken the ball for 948 frames and has earned 1,094 K's in his career. His earned run average is 3.16 (333 ER's allowed) and his WHIP is 1.073. He has allowed 742 hits (7.0 hits per nine innings) and has had 276 free passes. Burnes (63-37 career record) holds a FIP of 3.11 while he has gone up against 3,839 opposing batters in the major leagues.

The Dodgers hold a slugging percentage of .477 and they average 5.77 runs per outing (3rd in the league). They have tallied 81 two-baggers, while getting a free base 182 times and scoring 277 runs. Los Angeles has tallied 80 HRs this season to go along with 266 RBIs. They have struck out on 393 occasions (15th in the league) and have a total of 442 base hits. The Los Angeles Dodgers have compiled a team OBP of .345 in addition to a team batting average of .270 for the year.

The Los Angeles pitching staff have relinquished 218 runs so far this season while holding a team ERA of 4.28 (202 earned runs conceded). They have given up 62 home runs and they give up 4.62 runs per 9 innings (21st in MLB). The Dodgers hold a team WHIP of 1.304 and are the owners of a FIP of 4.22 as a staff for the year. Their K/BB ratio comes in at 9.30 (438 strikeouts vs 168 free passes). They are currently ranked 16th in baseball as a staff in total hits surrendered with 386.

With 62 save situations, the Dodgers have earned 35 holds and 9 blown saves. Los Angeles has called on relievers to step onto the hill in 25 save opportunities and they have walked away with 16 saves. Their relievers have stepped onto the mound 50 times in high leverage situations and also on 32 occasions with runners on base. Los Angeles bullpen pitchers have an inherited score percentage of 26.8% out of their 41 inherited base runners. They are currently ranked 16th in the league with a save percentage of 64.0%, and they have sent 176 relief pitchers onto the field for the year.

In 3,825 innings played, the Dodgers have a defensive efficiency of 70.0% (16th in baseball). The Los Angeles Dodgers have gotten 37 double plays and own a fielding percentage of .989 (5th in pro baseball). The Dodgers have racked up 415 assists, 18 errors and have accumulated 1,275 putouts over the course of the season.

In his MLB career, May has given up 184 hits while he has accumulated 215 punch outs in 235 innings pitched. He has conceded 88 earned runs while holding a WHIP of 1.096 and being the owner of a FIP of 3.3. His strikeout to walk ratio is 2.91 and he has gone up against 962 opposing batters during his pro baseball career. May (13-13 career mark) has earned a 3.36 earned run average and has surrendered 7.0 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Arizona (+125)

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