Arizona Diamondbacks vs Minnesota Twins Prediction, 9/12/2025 MLB Picks, Best Bets & Odds

Game: Arizona Diamondbacks vs Minnesota Twins

Date: Friday, September 12, 2025

Location: Target Field in Minneapolis, MN

TV: Twins.TV

Odds/Point Spread: Arizona (-152) Minnesota (+126)

The Arizona Diamondbacks (73-74) are en route to Target Field on Friday where they will try to defeat the Minnesota Twins (64-82). The moneyline on this matchup has the Diamondbacks at -152 while the Twins open at +126. The total comes in at 8.5. The pitchers who are expected to start are Brandon Pfaadt and Pablo Lopez.

The Diamondbacks have tallied 246 doubles as a unit and have hit 199 baseballs out of the park. Arizona owns a slugging percentage of .434 and have been rung up 1,190 times, while drawing a walk on 490 occasions. As a team, the Arizona Diamondbacks are putting up 4.9 runs per game, which has them at 6th in MLB. They have tallied 705 RBI's and 1,242 base knocks for the season, while their average at the plate sits at .250. They have tallied 724 runs and have an OBP of .323.

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The Diamondbacks have an earned run average of 4.47 on the year (23rd in baseball), and the staff has struck out 1,163 hitters. Diamondbacks pitchers have conceded 174 home runs in addition to 705 total runs (24th in baseball). They have walked 455 players from the other team and their FIP is 4.26 as a unit on the campaign. Arizona has given up 1,271 base hits (8.8 per 9 innings) as well as 650 earned runs. Their strikeout to walk ratio sits at 2.56 and their pitching staff has a collective WHIP of 1.32.

The Diamondbacks have sent 447 relief pitchers to the mound for the season. The bullpen pitchers have inherited 173 runners over the course of the season and 34.1% of them ended up scoring. They have accumulated 40 saves for the year and have blown 27 of 67 save opportunities. The Diamondbacks relief pitchers have accumulated a save rate of 59.7% and stepped onto the hill in 152 save situations. The bullpen are sitting with 81 holds on the year (15th in MLB). Diamondbacks pitchers have come into the game with opponents on base 132 times as well as having 145 appearances in high leverage situations.

The Diamondbacks have transformed 69.5% of baseballs in play into outs out of 11,769 innings on the field, ranking them 20th in pro baseball. The Arizona Diamondbacks have accounted for 3,923 putouts thus far, as well as 1,328 assists and 73 errors. Their fielding rate is currently at .986 which has them sitting 15th in MLB, and they have turned 116 double plays.

Pfaadt (27-27 career mark) holds a FIP of 5.03 and he has gone up against 1,854 opposing hitters in the major leagues. He has allowed 470 hits (9.8 hits per nine innings) and has 101 walks. His ERA is 5.10 (244 ER's allowed) and he has a WHIP of 1.327. Pfaadt has thrown 430 innings and has earned 408 strikeouts in his career.

The Minnesota Twins have earned a team OBP of .312 and a team batting average of .239 on the campaign. They have been rung up on 1,217 instances (16th in baseball) and have recorded 1,169 base knocks. Minnesota has knocked in 173 HRs so far this season as well as 585 RBIs. The Twins have a team slugging % of .398 and they are earning 4.23 runs per contest (23rd in baseball). They have tallied 223 two-baggers, while walking 453 times and putting up 617 runs.

The Minnesota pitching staff have relinquished 702 runs this season and come in with a team ERA of 4.60 (656 earned runs surrendered). They have given up 176 home runs and they yield 4.92 runs per 9 innings (24th in baseball). The Twins have a team WHIP of 1.330 and have a FIP of 4.14 as a pitching staff so far this year. Their strikeout to walk ratio sits at 8.60 (1,221 strikeouts vs 415 walks). They are currently ranked 26th in baseball as a staff in total hits allowed with 1,291.

Sitting with 139 save situations, the Twins have compiled 87 holds and 23 blown saves. Minnesota has called on relievers to take the mound in 50 save opportunities and they have walked away with 27 saves. Their relievers have stepped onto the hill 162 times in high leverage situations and on 110 occasions with base runners. Minnesota relief pitchers hold an inherited score rate of 36.3% out of 160 inherited base runners. They rank 27th in the league holding a save rate of 54.0%, and they have dispatched 492 bullpen pitchers onto the field for the year.

The Minnesota Twins have gotten 89 double plays and have earned a fielding percentage of .985 (18th in MLB). The Twins have accrued 1,092 assists, 75 errors and have notched a total of 3,849 putouts so far this year. In their 11,547 innings on the field, the Twins are sitting with a efficiency on defense of 68.2% (29th in professional baseball).

So far in his career, Lopez has given up 876 base hits while totaling 986 strikeouts in 955 innings pitched. Lopez (59-53 career record) is the owner of a 3.83 ERA and has given up 8.3 hits per 9 innings. He has given up a total of 407 ER's while earning a WHIP of 1.175 and being the owner of a FIP of 3.8. His strikeout to walk ratio is 4.01 and he has faced 3,955 hitters during his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Arizona (-152)

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