Arizona Diamondbacks vs San Diego Padres Prediction, 9/27/2025 MLB Picks, Best Bets & Odds

Game: Arizona Diamondbacks vs San Diego Padres

Date: Saturday, September 27, 2025

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: Arizona (+132) San Diego (-160)

The San Diego Padres (87-72) welcome the Arizona Diamondbacks (80-78) at Petco Park on Saturday. The moneyline on this contest has the Diamondbacks at +132 and the Padres are coming in at -160. The total has been set at 9. The pitchers taking the mound will be Eduardo Rodriguez and Michael King.

Arizona is slugging .434 and have been rung up 1,271 times, while drawing a walk on 527 occasions. They have earned 761 RBI's in addition to 1,348 base knocks on the season, while their average at the plate comes in at .252. The Diamondbacks have tallied 271 two-baggers as a team and have hit 210 baseballs out of the stadium. They have accounted for 782 runs while holding a team on-base percentage of .325. As a team, the Arizona Diamondbacks are notching 5.0 runs per game, which ranks them 4th in MLB.

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Their K/BB ratio is 2.59 and their pitching staff holds a WHIP of 1.31. Diamondbacks pitchers have given up 187 long balls and 753 total runs (23rd in the league). Arizona has allowed 1,362 hits (8.7 per 9 innings) as well as 693 earned runs. The Diamondbacks have a team earned run average of 4.42 for the year (23rd in the league), and the staff has rung up 1,254 hitters. Their pitching staff has walked 485 hitters and their FIP is 4.24 as a unit so far this season.

The Diamondbacks have sent 489 relief pitchers to the mound so far this year. The relief pitchers have inherited 192 base runners this season with 33.3% of those runners crossed home plate. They have earned 42 saves this year and have blown 29 of 71 save opportunities. The Diamondbacks bullpen have earned a save rate of 59.2% and have stepped onto the mound in 164 save situations. The relief pitchers have a total of 88 holds over the course of the season (14th in the league). Diamondbacks relief pitchers have come into the game with opponents on base 146 times and also have had 164 appearances in high leverage situations.

The Arizona Diamondbacks have earned a total of 4,233 putouts on the campaign, in addition to 1,412 assists and 80 errors. Their fielding rate is currently at .986 which is 16th in baseball, and they have turned 125 double plays. The Diamondbacks have turned 69.6% of balls hit into play into outs out of 12,699 innings on the diamond, which has them ranked 20th in baseball.

Rodriguez has thrown 1,298 innings and has accounted for 1,291 K's so far in his career. Rodriguez (94-65 career record) holds a FIP of 4.11 while he has gone up against 5,554 opposing batters in the majors. His ERA is 4.17 (602 earned runs allowed) and he has a career WHIP of 1.331. He has given up 1,274 base hits (8.8 hits per 9 innings) with 454 free passes.

San Diego has recorded 147 home runs on the season and 639 runs batted in. They have hit 248 two-baggers, while getting a free base 499 times as well as scoring 678 runs. The San Diego Padres have accumulated a team OBP of .320 in addition to a team batting average of .252 this year. The Padres have a team SLG% of .388 and they score 4.26 runs per contest (19th in the league). They have been rung up on 1,137 occasions (28th in MLB) and have totaled 1,339 hits.

The Padres have a team WHIP of 1.203 and have a FIP of 4.01 as a staff on the campaign. Their K/BB ratio is 8.90 (1,392 strikeouts vs 519 walks). They come in at 1st in baseball as a staff in total hits conceded with 1,173. They have allowed 174 long balls and they relinquish 3.92 runs per 9 innings (2nd in the league). The San Diego pitching staff have surrendered 612 runs for the season while having an ERA of 3.64 (569 earned runs surrendered).

Sitting with 172 save situations, the Padres have compiled 103 holds in addition to 16 blown saves. San Diego has had bullpen pitchers step onto the mound in 64 save opportunities and they have come away with 48 saves. Their relief pitchers have stepped onto the mound 208 times in high leverage situations in addition to 181 occasions with runners on. San Diego relievers hold an inherited score rate of 29.4% out of their 255 inherited base runners. They rank 1st in the league with a save percentage of 75.0%, and they have sent 564 relief pitchers onto the diamond for the year.

Out of their 12,654 innings played, the Padres have accumulated a defensive efficiency of 71.8% (3rd in professional baseball). The San Diego Padres have gotten 114 double plays and have accounted for a fielding rate of .987 (10th in professional baseball). The Padres have accrued 1,208 assists, 73 errors and have a total of 4,218 putouts this year.

So far in his career, King has surrendered 417 base hits while earning 556 punch outs in 491 frames. King (31-29 career win-loss mark) is the owner of a 3.26 earned run average and has given up 7.6 hits per nine innings. He has allowed a total of 178 earned runs while earning a WHIP of 1.195 and being the owner of a FIP of 3.2. His K/BB ratio is 3.27 and he has gone up against 2,057 hitters during his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take San Diego (-160)

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