Baltimore Orioles vs Chicago White Sox Prediction, 9/15/2025 MLB Picks, Best Bets & Odds

Game: Baltimore Orioles vs Chicago White Sox

Date: Monday, September 15, 2025

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: Baltimore (-150) Chicago (+125)

Rate Field is where the Chicago White Sox (57-90) will attempt to beat the Baltimore Orioles (69-77) on Monday. The odds on this game have Baltimore at -150 and Chicago is opening at +125. The over/under is set at 8.5. The starting pitchers will be Kyle Bradish and Sean Burke.

Baltimore has a slugging rate of .400 and have been rung up 1,297 times, while being walked on 424 occasions. They have accumulated 595 runs batted in and 1,177 hits so far this year, and their batting average is .240. The Orioles have hit 234 doubles as a team and have hit 173 baseballs out of the stadium. They have a total of 628 runs scored while holding a team OBP of .307. As a unit, the Baltimore Orioles are putting up 4.3 runs per contest, which puts them at 19th in the league.

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They have a K/BB ratio of 2.56 and the pitching staff has earned a collective WHIP of 1.37. Orioles pitchers have allowed 197 home runs in addition to 707 total runs (25th in baseball). Baltimore has conceded 1,297 base knocks (9.0 per 9 innings) as well as 658 earned runs. The Orioles are sitting with a team ERA of 4.58 on the year (24th in the league), and their staff has struck out 1,202 batters. Their pitching staff has walked 469 opposing hitters and their FIP sits at 4.45 as a unit on the campaign.

The Orioles have dispatched 490 relievers to the hill for the season. The relievers have inherited 197 base runners so far this year with 25.4% of those players ended up scoring. They have earned 34 saves for the season and have blown 19 of their 53 chances to get a save. The Orioles relief pitchers have a save percentage of 64.2% and have entered the game in 152 save situations. The bullpen have racked up 95 holds this year (4th in MLB). Orioles relief pitchers have entered the contest with opponents on base 142 times as well as having 154 appearances in high leverage situations.

The Atlanta Braves have 3,879 putouts for the season, as well as 1,296 assists and 79 errors. Their fielding rate sits at .985 which has them ranked 19th in MLB, and they have turned 105 double plays. The Orioles have turned 68.6% of balls in play into outs in their 11,637 innings, ranking them 26th in the majors.

Bradish (18-15 career win-loss mark) holds a FIP of 3.47 while he has faced 1,408 opposing hitters in the major leagues. He has surrendered 290 base knocks (7.6 hits per 9 innings) and has had 109 walks. His ERA is 3.52 (134 earned runs allowed) and his career WHIP is 1.166. Bradish has taken the ball for 342 innings and has accumulated 353 strikeouts thus far in his career.

Chicago has recorded 150 home runs for the year as well as 577 runs batted in. They have hit 228 two-baggers, while taking a walk 461 times as well as scoring 597 runs. The Chicago White Sox are sitting with a team OBP of .305 as well as a batting average of .236 on the campaign. The White Sox have a team SLG% of .378 and they average 4.06 runs per contest (26th in MLB). They have been called out on strikes on 1,226 instances (14th in the league) and have notched a total of 1,153 base knocks.

The White Sox are sitting with a team WHIP of 1.364 and have a FIP of 4.47 as a unit on the campaign. Their K/BB ratio sits at 8.00 (1,147 strikeouts vs 544 bases on balls). They come in at 16th in baseball as a pitching staff in total hits conceded with 1,211. They have allowed 166 homers and they relinquish 4.71 runs per 9 innings (22nd in MLB). The Chicago pitching staff have allowed 673 runs so far this season while having an ERA of 4.22 (604 earned runs allowed).

Chicago has had relief pitchers enter the game in 44 save chances and they have come away with 23 saves. They sit at 28th in MLB holding a save percentage of 52.3%, and they have sent 479 relievers to the hill over the course of the season. Their relief pitchers have come in 141 times in high leverage situations and also on 148 occasions with base runners. Chicago bullpen pitchers hold an inherited score percentage of 32.1% out of their 215 inherited base runners. With 110 save situations, the White Sox have 64 holds in addition to 21 blown saves.

The Chicago White Sox have gotten 118 double plays and have notched a fielding percentage of .981 (28th in baseball). The White Sox have racked up 1,168 assists, 95 errors and have earned 3,862 putouts so far this season. In their 11,586 innings on the field, the White Sox hold a efficiency on defense of 69.7% (17th in professional baseball).

Burke (6-10 career mark) has a 3.96 earned run average and has conceded 8.5 hits per nine innings. He has a K/BB ratio of 2.11 and he has gone up against 618 opposing hitters during his pro baseball career. He has allowed 62 ER's while holding a WHIP of 1.404 and a FIP of 3.9. In his pro baseball career, Burke has conceded 133 hits while totaling 137 strikeouts in 141 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Baltimore (-150)

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