Baltimore Orioles vs Chicago White Sox Prediction, 9/16/2025 MLB Picks, Best Bets & Odds

Game: Baltimore Orioles vs Chicago White Sox

Date: Tuesday, September 16, 2025

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: Baltimore (-128) Chicago (+106)

The Baltimore Orioles (69-80) are traveling to Rate Field on Tuesday where they will play the Chicago White Sox (57-93). The odds on this game have Baltimore at -128 and Chicago is coming in at +106. The betting total is set at 8. The expected starting pitchers will be Tyler Wells and Shane Smith.

As a team, the Baltimore Orioles are earning 4.3 runs per contest, which puts them at 22nd in MLB. They are sitting with 635 runs while holding a team on-base percentage of .306. The Orioles have accounted for 237 doubles as a team and have hit 176 balls out of the park. They have tallied 602 runs batted in and 1,194 base knocks on the campaign, while their batting average sits at .239. Baltimore has a slugging rate of .399 and have been called out on strikes 1,323 times, while taking a walk on 434 occasions.

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The Orioles are sitting with a team ERA of 4.63 this year (25th in the league), and they have rung up 1,222 batters. Orioles pitchers have yielded 199 long balls in addition to 729 total runs (25th in the league). Their pitching staff has walked 479 hitters and their FIP sits at 4.44 as a team so far this year. Baltimore has relinquished 1,333 base hits (9.1 per 9 innings) as well as 678 earned runs. Their strikeout to walk ratio is 2.55 and their pitching staff has a team WHIP of 1.38.

Orioles pitchers have entered the game with players on base 145 times as well as having 159 appearances in high leverage situations. The relief pitchers have 98 holds on the campaign (4th in MLB). The Orioles relievers have recorded a save percentage of 63.0% and have entered the game in 156 save situations. They have recorded 34 saves this year and have blown 20 of their 54 chances to get a save. The bullpen pitchers have inherited 202 base runners this year with 26.2% of those runners ended up crossing the plate. The Orioles have dispatched 499 relief pitchers to the hill this season.

The Atlanta Braves have a total of 3,953 putouts over the course of the season, as well as 1,319 assists and 83 errors. Their fielding percentage sits at .985 which ranks 20th in MLB, and they have turned 108 double plays. The Orioles have transformed 68.3% of balls hit into play into outs out of their 11,859 innings on the field, ranking them 27th in the majors.

Wells has pitched in 305 innings and has accumulated 281 punch outs so far in his career. His earned run average is 4.01 (136 earned runs allowed) and he has a WHIP of 1.031. He has surrendered 237 hits (7.0 hits per 9 innings) with 78 walks. Wells (17-18 record in his career) has a FIP of 3.95 and he has faced 1,226 hitters during his time in the major leagues.

Chicago is sitting with 151 home runs for the year as well as 580 RBIs. They have put up 230 two-baggers, while walking 463 times as well as notching 600 runs. The Chicago White Sox hold an OBP of .303 in addition to a batting average of .234 on the season. The White Sox have a team slugging percentage of .375 and they are earning 4.00 runs per game (26th in baseball). They have been called out on strikes on 1,256 instances (14th in the league) and have a total of 1,168 base knocks.

The White Sox hold a team WHIP of 1.358 with a FIP of 4.49 as a unit over the course of the season. They are currently ranked 15th in the league as a pitching staff in total hits given up with 1,229. The Chicago pitching staff have relinquished 683 runs over the course of the season while holding an ERA of 4.21 (614 earned runs surrendered). Their strikeout to walk ratio comes in at 8.00 (1,162 strikeouts against 551 walks). They have given up 171 long balls and they concede 4.69 runs per 9 innings (20th in baseball).

Chicago relief pitchers hold an inherited score percentage of 32.1% out of their 218 inherited runners. Their relief pitchers have taken the field 141 times in high leverage situations and on 150 occasions with runners on base. With 110 save situations, the White Sox have earned 64 holds and 21 blown saves. They are ranked 29th in the league with a save rate of 52.3%, and they have sent 485 relievers to the hill on the year. Chicago has had bullpen pitchers enter the game in 44 save chances and they have come away with 23 saves.

In 11,802 innings on the field, the White Sox hold a defensive efficiency of 69.9% (15th in professional baseball). The Chicago White Sox have gotten 120 double plays and have a fielding rate of .982 (28th in MLB). The White Sox have recorded 1,189 assists, 95 errors and have accumulated 3,934 putouts for the season.

In his MLB career, Smith has conceded 102 hits and he has 122 K's in 131 frames. He has conceded 55 ER's while earning a WHIP of 1.183 and having a FIP of 3.7. He has a strikeout to walk ratio of 2.30 and he has gone up against 551 batters in his pro baseball career. Smith (6-7 career mark) is the owner of a 3.78 earned run average and has conceded 7.0 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Baltimore (-128)

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