Baltimore Orioles vs Milwaukee Brewers Prediction, 5/21/2025 MLB Picks, Best Bets & Odds

Game: Baltimore Orioles vs Milwaukee Brewers

Date: Wednesday, May 21, 2025

Location: American Family Field in Milwaukee, WI

TV: FanDuel Sports Network Wisconsin

Odds/Point Spread: Baltimore (+126) Milwaukee (-152)

The Milwaukee Brewers (23-25) will play the Baltimore Orioles (15-31) at American Family Field on Wednesday. The moneyline on this game has the Orioles at +126 and the Brewers are opening at -152. The over/under is set at 8. The starting pitchers are Tomoyuki Sugano and Chad Patrick.

As a squad, the Baltimore Orioles are notching 3.8 runs per game, which is 25th in the league. They have notched a total of 173 runs scored while having a team OBP of .298. The Orioles have earned 63 doubles as a squad and have hit 55 balls out of the park. They have earned 164 RBI's in addition to 349 base knocks for the season, while their average at the plate is sitting at .230. Baltimore is slugging .388 and have been called out on strikes 407 times, while being walked on 130 occasions.

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Their strikeout to walk ratio sits at 2.21 and the pitching staff has earned a collective WHIP of 1.49. Orioles pitchers have allowed 72 home runs and also 259 runs in total (27th in baseball). Baltimore has surrendered 434 hits (9.8 per 9 innings) as well as 245 earned runs. The Orioles have a team ERA of 5.53 so far this year (29th in the league), and their staff has struck out 351 hitters. Their pitching staff has walked 159 opposing batters and their FIP comes in at 5.00 as a unit for the year.

Orioles bullpen pitchers have entered the contest with runners on 54 times in addition to having 36 appearances in high leverage situations. The relief pitchers are sitting with 26 holds over the course of the season (17th in baseball). The Orioles relievers have a save percentage of 70.0% and have entered the game in 39 save situations. They have compiled 7 saves for the season and have blown 3 of their 10 save opportunities. The relievers have inherited 71 runners so far this season and 25.4% of those runners ended up crossing the plate. The Orioles have sent 158 relief pitchers to the hill so far this season.

The Orioles have transformed 67.6% of balls in play into outs out of their 3,591 innings, which ranks them 26th in baseball. The Atlanta Braves have a total of 1,197 putouts thus far, as well as 416 assists and 25 errors. Their fielding rate is at .985 which ranks 21st in baseball, and have accumulated 34 double plays.

Sugano has thrown 52 frames and has accumulated 29 punch outs in his pro baseball career. His ERA is 3.10 (18 earned runs allowed) and his career WHIP is 1.034. He has conceded 45 base hits (7.8 hits per nine innings) and has 9 walks. Sugano (4-3 win-loss mark in his career) has a FIP of 3.06 while he has gone up against 208 opposing batters in the major leagues.

The Milwaukee Brewers have a team on-base percentage of .308 and a team batting average of .230 this year. They have been called out on strikes on 393 occasions (16th in MLB) and have earned a total of 363 hits. Milwaukee has accumulated 37 home runs this year to go along with 184 runs batted in. The Brewers have a team slugging % of .347 and they score 4.23 runs per game (16th in the league). They have hit 63 doubles, while walking 162 times and racking up 203 runs.

The Brewers have a WHIP of 1.324 and have a FIP of 4.36 as a unit for the year. Their strikeout to walk ratio is 8.10 (379 strikeouts against 178 free passes). They have a ranking of 12th in baseball as a pitching staff in total hits conceded with 377. They have relinquished 54 dingers and they concede 4.49 runs per 9 innings (18th in MLB). The Milwaukee pitching staff have yielded 209 runs so far this year while holding a team ERA of 4.14 (193 earned runs allowed).

Milwaukee relief pitchers hold an inherited score rate of 37.3% of 75 inherited runners. Their relief pitchers have stepped onto the mound 49 times in high leverage situations and on 45 occasions with base runners. Sitting with 46 save situations, the Brewers have amassed 31 holds and also 5 blown saves. They are currently ranked 15th in baseball holding a save percentage of 64.3%, and they have sent 175 bullpen pitchers to the mound this season. Milwaukee has had relief pitchers enter the game in 14 save chances and they have earned 9 saves.

Out of their 3,777 innings on the diamond, the Brewers hold a efficiency on defense of 70.7% (11th in professional baseball). The Milwaukee Brewers have turned 34 double plays and have accounted for a fielding rate of .982 (25th in baseball). The Brewers have accrued 366 assists, 30 errors and have 1,259 putouts on the season.

Patrick (2-4 career win-loss record) is the owner of a 3.37 earned run average while conceding 8.8 hits per 9 innings. He has a strikeout to walk ratio of 2.53 and he has gone up against 202 opposing batters thus far in his career. He has conceded 18 ER's while earning a WHIP of 1.289 and having a FIP of 3.3. In his career, Patrick has conceded 47 base hits and he has 38 strikeouts in 48 frames.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Baltimore (+126)

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