Baltimore Orioles vs New York Yankees Prediction, 9/27/2025 MLB Picks, Best Bets & Odds

Game: Baltimore Orioles vs New York Yankees

Date: Saturday, September 27, 2025

Location: Yankee Stadium in Bronx, NY

TV: YES

Odds/Point Spread: Baltimore (+172) New York (-210)

Yankee Stadium is the site where the New York Yankees (90-68) will attempt to beat the Baltimore Orioles (74-84) on Saturday. The moneyline on this contest has the Orioles at +172 and the Yankees open at -210. The total is set at 8.5. The starting pitchers will be Tomoyuki Sugano and Cam Schlittler.

Baltimore owns a slugging percentage of .394 and have struck out 1,413 times, while taking a walk on 469 occasions. They have recorded 631 RBI's and 1,249 base knocks this season, while their team batting average is sitting at .236. The Orioles have tallied 248 doubles as a squad and have hit 183 baseballs out of the park. They have accumulated 664 runs while holding a team on-base percentage of .305. As a team, the Baltimore Orioles are putting up 4.2 runs/g, which ranks them 23rd in baseball.

Get all of our MLB Parlay Picks

The Orioles have a team ERA of 4.57 over the course of the season (24th in baseball), and their staff has struck out 1,316 batters. Orioles pitchers have given up 209 home runs and 766 total runs (24th in baseball). They have walked 510 opposing batters and their FIP comes in at 4.39 as a unit so far this season. Baltimore has surrendered 1,396 base hits (9.0 per 9 innings) as well as 711 earned runs. Their K/BB ratio is 2.58 and their pitching staff holds a collective WHIP of 1.36.

Orioles relief pitchers have gone to the mound with runners on 151 times and also have had 167 appearances in high leverage situations. The relievers have earned 105 holds on the campaign (4th in baseball). The Orioles relief pitchers have earned a save percentage of 65.5% and have entered the game in 167 save situations. They have recorded 38 saves so far this year and have not converted 20 out of their 58 chances to save the game. The relief pitchers have inherited 210 runners over the course of the season with 26.7% of those players ended up scoring. The Orioles have dispatched 529 relievers to the mound on the season.

The Atlanta Braves have amassed 4,199 putouts so far this season, as well as 1,378 assists and 87 errors. Their fielding percentage is at .985 which has them sitting 20th in professional baseball, and have earned 118 double plays. The Orioles have turned 68.5% of balls hit into play into outs out of their 12,597 innings, which ranks them 26th in baseball.

Sugano has taken the ball for 152 innings and has racked up 103 K's so far in his career. Sugano (10-9 career mark) holds a FIP of 4.48 while he has gone up against 657 hitters in the major leagues. His earned run average is 4.55 (77 ER's allowed) and he has a WHIP of 1.340. He has given up 168 hits (9.9 hits per 9 innings) and has had 36 free passes.

The Yankees hold a slugging percentage of .454 and they are recording 5.23 runs per game (1st in baseball). They have notched 252 two-baggers, while walking 621 times and scoring 827 runs. New York has accounted for 266 home runs this year to go along with 798 RBIs. They have struck out on 1,429 instances (3rd in MLB) and have a total of 1,341 hits. The New York Yankees hold an OBP of .332 as well as a team batting average of .251 on the year.

The New York pitching staff have allowed 675 runs this year and come in with a team ERA of 3.94 (615 earned runs relinquished). They have conceded 169 homers and they concede 4.33 runs per 9 innings (14th in the league). The Yankees are sitting with a team WHIP of 1.256 in addition to having a FIP of 3.99 as a squad for the year. Their strikeout to walk ratio sits at 9.00 (1,401 strikeouts against 544 walks). They have a ranking of 4th in the league as a pitching staff in total hits relinquished with 1,219.

New York relievers have an inherited score rate of 27.8% out of 252 inherited base runners. Their relievers have stepped onto the hill 160 times in high leverage situations and on 166 occasions with runners on base. With 159 save situations, the Yankees have compiled 95 holds in addition to 21 blown saves. They are ranked 7th in baseball holding a save rate of 66.1%, and they have sent 520 relief pitchers to the hill so far this year. New York has called on relievers to step onto the hill in 62 save opportunities and they have converted 41 saves.

In 12,633 innings on the diamond, the Yankees have accumulated a defensive efficiency of 70.5% (10th in pro baseball). The New York Yankees have turned 105 double plays and have a fielding percentage of .984 (25th in pro baseball). The Yankees have 1,361 assists, 92 errors and have 4,211 putouts for the season.

During his MLB career, Schlittler has allowed 56 hits while he has earned 75 K's in 66 frames. Schlittler (3-3 mark in his career) has a 3.27 earned run average and has conceded 7.6 hits per nine innings. He has allowed 24 ER's while earning a WHIP of 1.303 and being the owner of a FIP of 3.2. He has a K/BB ratio of 2.50 and he has faced 278 opposing hitters during his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Baltimore (+172)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here