Boston Red Sox vs Arizona Diamondbacks Prediction, 9/5/2025 MLB Picks, Best Bets & Odds

Game: Boston Red Sox vs Arizona Diamondbacks

Date: Friday, September 5, 2025

Location: Chase Field in Phoenix, AZ

TV: DBACKS.TV

Odds/Point Spread: Boston (-160) Arizona (+132)

Chase Field is the site where the Arizona Diamondbacks (70-71) will compete against the Boston Red Sox (78-63) on Friday. The odds on this game have the Red Sox at -160 while the Diamondbacks are priced at +132. The over/under comes in at 8. The starting pitchers are Lucas Giolito and Eduardo Rodriguez.

Boston has a slugging percentage of .426 and have been called out on strikes 1,245 times, while being walked on 456 occasions. They have 664 RBI's as well as 1,231 base knocks over the course of the season, and their team batting average sits at .254. The Red Sox have recorded 283 doubles as a squad and have smacked 169 baseballs out of the park. They have racked up 696 runs while having a team OBP of .325. As a squad, the Boston Red Sox are scoring 4.9 runs per outing, which puts them at 5th in the league.

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Their strikeout to walk ratio is 2.52 and their pitching staff sits with a WHIP of 1.29. Red Sox pitchers have surrendered 145 long balls and 595 total runs (13th in the league). Boston has allowed 1,165 base hits (8.3 per 9 innings) and 524 earned runs. The Red Sox have a team ERA of 3.73 so far this season (5th in baseball), and their staff has rung up 1,166 batters. Their pitching staff has walked 462 opposing hitters and their FIP sits at 4.04 as a team this year.

Red Sox bullpen pitchers have stepped onto the hill with opponents on base 139 times in addition to having 169 appearances in high leverage situations. The relievers are sitting with 76 holds so far this year (18th in MLB). The Red Sox relievers have accumulated a save rate of 62.5% and have stepped onto the mound in 142 save situations. They have accumulated 40 saves over the course of the season and have missed out on 24 of their 64 chances to save the game. The relief pitchers have inherited 187 runners over the course of the season with 32.6% of them ended up scoring. The Red Sox have dispatched 462 relievers to the mound on the campaign.

The Red Sox have turned 69.2% of balls in play into outs out of 11,367 innings on the field, which ranks them 21st in MLB. The Baltimore Orioles have a tally of 3,789 putouts this season, in addition to 1,289 assists and 105 errors. Their fielding rate sits at .980 which is 30th in baseball, and they have turned 115 double plays.

Giolito has taken the hill for 1,138 innings and has accumulated 1,182 strikeouts so far in his career. Giolito (71-64 career record) has a FIP of 4.25 while facing 4,780 opposing hitters in the major leagues. His earned run average is 4.32 (546 ER's allowed) and he has a WHIP of 1.252. He has surrendered 997 base hits (7.9 hits per nine innings) and has had 428 free passes.

The Arizona Diamondbacks have accounted for an OBP of .322 in addition to a batting average of .249 on the year. They have been rung up on 1,144 instances (18th in MLB) and are sitting with 1,189 base hits. Arizona has 194 home runs on the year as well as 676 runs batted in. The Diamondbacks have a SLG% of .436 and they are scoring 4.91 runs per game (6th in the league). They have put up 240 two-baggers, while walking 468 times and scoring 692 runs.

The Arizona pitching staff have given up 673 runs so far this year while having a team ERA of 4.45 (621 earned runs conceded). They have allowed 167 HR's and they relinquish 4.83 runs per 9 innings (23rd in the league). The Diamondbacks are sitting with a team WHIP of 1.326 with a FIP of 4.26 as a unit this season. Their strikeout to walk ratio sits at 8.00 (1,122 strikeouts against 440 walks). They are currently ranked 25th in baseball as a staff in total hits given up with 1,225.

Arizona relievers hold an inherited score rate of 30.6% out of their 160 inherited runners. Their relievers have come in 141 times in high leverage situations and also on 125 occasions with base runners. With 148 save situations, the Diamondbacks have accrued 78 holds in addition to 26 blown saves. They sit at 22nd in the league with a save rate of 60.6%, and they have sent 431 bullpen pitchers onto the diamond on the year. Arizona has called on relievers to enter the game in 66 save chances and they have earned 40 saves.

The Arizona Diamondbacks have gotten 110 double plays and hold a fielding percentage of .986 (14th in the majors). The Diamondbacks have accrued 1,269 assists, 70 errors and have earned 3,767 putouts on the campaign. In 11,301 innings played, the Diamondbacks are sitting with a defensive efficiency of 69.3% (20th in professional baseball).

During his MLB career, Rodriguez has allowed 1,254 hits while he has totaled 1,274 strikeouts in 1,275 frames. Rodriguez (91-65 record in his career) has earned a 4.21 earned run average while conceding 8.9 hits per 9 innings. He has allowed a total of 596 earned runs while holding a WHIP of 1.333 and being the owner of a FIP of 4.1. His strikeout to walk ratio is 2.86 and he has gone up against 5,458 batters so far in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Boston (-160)

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