Boston Red Sox vs Arizona Diamondbacks Prediction, 9/6/2025 MLB Picks, Best Bets & Odds

Game: Boston Red Sox vs Arizona Diamondbacks

Date: Saturday, September 6, 2025

Location: Chase Field in Phoenix, AZ

TV: DBACKS.TV

Odds/Point Spread: Boston (-132) Arizona (+110)

The Arizona Diamondbacks (70-71) will play the Boston Red Sox (78-63) at Chase Field on Saturday. The line on this matchup has Boston at -132 while Arizona is coming in at +110. The betting total comes in at 8.5. The pitchers taking the mound will be Lucas Giolito and Brandon Pfaadt.

Boston is slugging .426 and have struck out 1,245 times, while drawing a walk on 456 occasions. They have recorded 664 runs batted in and 1,231 base knocks so far this season, and their batting average comes in at .254. The Red Sox have hit 283 doubles as a squad and have smacked 169 balls out of the park. They have tallied 696 runs and hold an OBP of .325. As a squad, the Boston Red Sox are compiling 4.9 runs/g, which is 5th in MLB.

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The Red Sox have an earned run average of 3.73 this year (5th in the league), and the staff has struck out 1,166 hitters. Red Sox pitchers have given up 145 home runs and also 595 runs (13th in MLB). Their pitching staff has walked 462 opposing players and their FIP comes in at 4.04 as a unit over the course of the season. Boston has allowed 1,165 hits (8.3 per 9 innings) as well as 524 earned runs. They have earned a K/BB ratio of 2.52 and their pitching staff holds a WHIP of 1.29.

Red Sox relief pitchers have come into the game with players on base 139 times as well as having 169 appearances in high leverage situations. The relievers have racked up 76 holds on the year (18th in MLB). The Red Sox relief pitchers have accumulated a save percentage of 62.5% and stepped onto the hill in 142 save situations. They have earned 40 saves this season and have blown 24 of 64 chances to get a save. The relief pitchers have inherited 187 base runners so far this year with 32.6% of those runners ended up scoring. The Red Sox have dispatched 462 relievers to the hill so far this season.

The Red Sox have converted 69.2% of baseballs in play into outs in their 11,367 innings on the field, which has them sitting 21st in baseball. The Baltimore Orioles are sitting with 3,789 putouts at this point in the season, as well as 1,289 assists and 105 errors. Their fielding rate is holding at .980 which is 30th in professional baseball, and have accumulated 115 double plays.

Giolito has taken the hill for 1,138 frames and has accumulated 1,182 strikeouts so far in his career. His earned run average is 4.32 (546 earned runs allowed) and he has a WHIP of 1.252. He has allowed 997 base knocks (7.9 hits per 9 innings) with 428 walks. Giolito (71-64 win-loss mark in his career) sits with a FIP of 4.25 while he has gone up against 4,780 hitters during his time in the major leagues.

Arizona has accumulated 194 long balls on the season as well as 676 runs batted in. They have hit 240 doubles, while getting a free base 468 times and scoring 692 runs. The Arizona Diamondbacks have an OBP of .322 and a team batting average of .249 on the campaign. The Diamondbacks hold a team slugging % of .436 and they tally 4.91 runs per outing (6th in MLB). They have been rung up on 1,144 instances (18th in the league) and have tallied 1,189 base knocks.

The Diamondbacks hold a team WHIP of 1.326 in addition to having a FIP of 4.26 as a pitching staff on the season. They have earned a strikeout to walk ratio of 8.00 (1,122 strikeouts against 440 walks). They are currently ranked 25th in the league as a staff in total hits allowed with 1,225. They have surrendered 167 long balls and they relinquish 4.83 runs per 9 innings (23rd in baseball). The Arizona pitching staff have surrendered 673 runs so far this season while having a team ERA of 4.45 (621 earned runs allowed).

Arizona has had relievers take the mound in 66 save chances and they have converted 40 saves. They are ranked 22nd in baseball with a save percentage of 60.6%, and they have sent 431 relievers onto the field for the year. Their relief pitchers have stepped onto the mound 141 times in high leverage situations in addition to 125 occasions with runners on base. Arizona relief pitchers have an inherited score rate of 30.6% of 160 inherited base runners. With 148 save situations, the Diamondbacks have amassed 78 holds and 26 blown saves.

The Arizona Diamondbacks have turned 110 double plays and have a fielding rate of .986 (14th in baseball). The Diamondbacks have racked up 1,269 assists, 70 errors and have earned 3,767 putouts for the season. In their 11,301 innings on the field, the Diamondbacks hold a defensive efficiency of 69.3% (20th in the majors).

Pfaadt (26-27 mark in his career) has earned a 5.16 earned run average while surrendering 9.8 hits per nine innings. He has a K/BB ratio of 3.97 and he has gone up against 1,830 opposing hitters during his pro baseball career. He has surrendered a total of 243 ER's while earning a WHIP of 1.332 and having a FIP of 5.1. So far in his career, Pfaadt has given up 464 base hits while he has totaled 401 K's in 424 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Boston (-132)

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