Boston Red Sox vs Arizona Diamondbacks Prediction, 9/7/2025 MLB Picks, Best Bets & Odds

Game: Boston Red Sox vs Arizona Diamondbacks

Date: Sunday, September 7, 2025

Location: Chase Field in Phoenix, AZ

TV: DBACKS.TV

Odds/Point Spread: Boston (-150) Arizona (+125)

The Boston Red Sox (78-63) are en route to Chase Field on Sunday where they will go up against the Arizona Diamondbacks (70-71). The line on this matchup has Boston at -150 and Arizona is coming in at +125. The betting total comes in at 8.5. The pitchers who are expected to start will be Brayan Bello and Ryne Nelson.

As a squad, the Boston Red Sox are putting up 4.9 runs per contest, which has them at 5th in baseball. They have racked up 696 runs scored while holding a team OBP of .325. The Red Sox have accumulated 283 doubles as a squad and have hit 169 balls out of the park. They have tallied 664 runs batted in and 1,231 hits this year, while their average at the plate comes in at .254. Boston has a slugging rate of .426 and have been called out on strikes 1,245 times, while being walked on 456 occasions.

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They have accumulated a K/BB ratio of 2.52 and the pitching staff sits with a WHIP of 1.29. Red Sox pitchers have allowed 145 home runs in addition to 595 runs in total (11th in baseball). Boston has given up 1,165 hits (8.3 per 9 innings) as well as 524 earned runs. The Red Sox have compiled a team earned run average of 3.73 this season (5th in baseball), and their staff has struck out 1,166 batters. Their pitching staff has walked 462 opposing players and their FIP comes in at 4.04 as a team this year.

The Red Sox have sent 462 relief pitchers to the hill on the season. The relievers have inherited 187 base runners on the season and 32.6% of those players crossed the plate. They have accumulated 40 saves on the year and have blown 24 of 64 save opportunities. The Red Sox bullpen have earned a save rate of 62.5% and have entered the game in 142 save situations. The relief pitchers have earned 76 holds on the year (18th in baseball). Red Sox pitchers have stepped onto the hill with runners on 139 times and also have had 169 appearances in high leverage situations.

The Red Sox have turned 69.2% of balls hit into play into outs out of their 11,367 innings on the field, which has them sitting at 21st in the majors. The Baltimore Orioles have notched a total of 3,789 putouts this year, in addition to 1,289 assists and 105 errors. Their fielding rate sits at .980 which puts them in 30th in the majors, and have earned 115 double plays.

Bello has taken the hill for 522 frames and has 452 strikeouts in his MLB career. Bello (39-33 career mark) has a FIP of 3.99 while he has gone up against 2,250 batters in the majors. His earned run average is 4.05 (235 earned runs allowed) and he has a WHIP of 1.365. He has surrendered 527 base hits (9.1 hits per 9 innings) with 186 walks.

The Diamondbacks hold a team SLG% of .436 and they average 4.91 runs per game (6th in the league). They have 240 doubles, while getting a free base 468 times and putting up 692 runs. Arizona has tallied 194 home runs on the campaign as well as 676 runs batted in. They have been rung up on 1,144 instances (19th in baseball) and have 1,189 hits. The Arizona Diamondbacks have earned an on-base percentage of .322 in addition to a team batting average of .249 so far this year.

The Diamondbacks hold a team WHIP of 1.326 and are the owners of a FIP of 4.26 as a team for the year. They are sitting at 24th in the league as a pitching staff in total hits conceded with 1,225. The Arizona pitching staff have given up 673 runs so far this year and come in with a team ERA of 4.45 (621 earned runs conceded). Their K/BB ratio comes in at 8.00 (1,122 strikeouts against 440 free passes). They have yielded 167 dingers and they concede 4.83 runs per 9 innings (23rd in the league).

Arizona has had relief pitchers enter the game in 66 save chances and they have walked away with 40 saves. They rank 23rd in baseball with a save rate of 60.6%, and they have sent 431 relievers to the hill over the course of the season. Their relievers have come in 141 times in high leverage situations and also on 125 occasions with runners on. Arizona relievers have an inherited score percentage of 30.6% of 160 inherited runners. With 148 save situations, the Diamondbacks have amassed 78 holds and 26 blown saves.

The Arizona Diamondbacks have turned 110 double plays and have a fielding percentage of .986 (15th in MLB). The Diamondbacks have 1,269 assists, 69 errors and have earned 3,767 putouts on the campaign. In their 11,301 innings played, the Diamondbacks are sitting with a defensive efficiency of 69.4% (19th in baseball).

During his MLB career, Nelson has given up 428 base knocks while accumulating 353 strikeouts in 444 frames. Nelson (26-18 career mark) has a 4.28 ERA while giving up 8.7 hits per 9 innings. He has surrendered 211 earned runs while holding a WHIP of 1.232 and having a FIP of 4.2. He has a K/BB ratio of 2.97 and he has gone up against 1,846 batters in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Boston (-150)

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