Boston Red Sox vs Houston Astros Prediction, 8/13/2025 MLB Picks, Best Bets & Odds

Game: Boston Red Sox vs Houston Astros

Date: Wednesday, August 13, 2025

Location: Daikin Park in Houston, TX

TV: Space City Home Network

Odds/Point Spread: Boston (+110) Houston (-132)

The Boston Red Sox (65-54) are hitting the road to Daikin Park on Wednesday where they will go up against the Houston Astros (66-52). The line on this contest has the Red Sox at +110 while the Astros are coming in at -132. The over/under comes in at 8.5. The expected starting pitchers are Walker Buehler and Hunter Brown.

Boston has a slugging percentage of .428 and have struck out 1,065 times, while taking a walk on 384 occasions. They have tallied 567 runs batted in and 1,034 base knocks so far this season, and their batting average is sitting at .253. The Red Sox have accounted for 244 doubles as a unit and have knocked 143 baseballs out of the park. They have 593 runs scored and have an OBP of .324. As a unit, the Boston Red Sox are scoring 5.0 runs per outing, which is 5th in the league.

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The Red Sox have a team ERA of 3.73 for the year (9th in baseball), and the staff has rung up 980 hitters. Red Sox pitchers have surrendered 119 home runs in addition to 509 total runs (15th in baseball). They have walked 399 hitters and their FIP comes in at 4.00 as a team for the year. Boston has given up 990 base knocks (8.4 per 9 innings) as well as 442 earned runs. They have earned a K/BB ratio of 2.46 and their pitching staff has a collective WHIP of 1.30.

Red Sox pitchers have entered the game with runners on 121 times in addition to having 145 appearances in high leverage situations. The relief pitchers have racked up 64 holds this season (19th in the league). The Red Sox relievers have a save rate of 59.3% and have come into the game in 120 save situations. They have recorded 32 saves this year and have blown 22 of 54 save opportunities. The bullpen pitchers have inherited 163 base runners over the course of the season and 30.7% of those runners ended up scoring. The Red Sox have dispatched 390 relievers to the mound for the year.

The Baltimore Orioles have notched a total of 3,198 putouts on the year, as well as 1,090 assists and 93 errors. Their fielding rate is holding steady at .979 which puts them in 29th in baseball, and they have turned 98 double plays. The Red Sox have transformed 68.9% of baseballs in play into outs out of their 9,594 innings, which has them ranked 23rd in MLB.

Buehler has taken the hill for 813 innings and has earned 829 strikeouts so far in his MLB career. Buehler (54-28 win-loss record in his career) has earned a FIP of 3.48 and he has faced 3,354 hitters during his time in the majors. His earned run average is 3.53 (319 ER's allowed) and he has a career WHIP of 1.149. He has surrendered 698 base knocks (7.7 hits per 9 innings) and has had 236 free passes.

Houston has hit 131 long balls on the campaign to go along with 491 RBIs. They have hit 186 two-baggers, while getting a free base 344 times and notching 513 runs. The Houston Astros have accumulated a team OBP of .323 and a team batting average of .258 over the course of the season. The Astros hold a team slugging % of .408 and they score 4.35 runs per outing (15th in MLB). They have been called out on strikes on 922 instances (24th in baseball) and have recorded 1,034 base hits.

The Houston pitching staff have yielded 459 runs on the season while having a team ERA of 3.69 (430 earned runs conceded). They have surrendered 136 dingers and they yield 3.94 runs per 9 innings (5th in the league). The Astros have a WHIP of 1.192 in addition to having a FIP of 3.79 as a unit so far this season. Their K/BB ratio sits at 9.70 (1,125 strikeouts against 353 free passes). They sit at 3rd in the league as a staff in total hits surrendered with 897.

Houston bullpen pitchers hold an inherited score percentage of 25.9% of 116 inherited base runners. Their bullpen pitchers have come in 117 times in high leverage situations in addition to 84 occasions with runners on base. Sitting with 117 save situations, the Astros have 69 holds in addition to 12 blown saves. They rank 1st in baseball with a save percentage of 73.9%, and they have dispatched 366 relievers to the hill over the course of the season. Houston has called on relief pitchers to enter the contest in 46 save chances and they have converted 34 saves.

In 9,441 innings on the diamond, the Astros have accumulated a defensive efficiency of 70.7% (11th in baseball). The Houston Astros have turned 74 double plays and own a fielding percentage of .988 (7th in professional baseball). The Astros have 919 assists, 48 errors and have earned a total of 3,147 putouts this year.

So far in his career, Brown has surrendered 422 base hits and he has 539 punch outs in 482 innings pitched. Brown (33-27 career win-loss mark) has a 3.62 ERA and has given up 7.9 hits per 9 innings. He has surrendered 194 earned runs while earning a WHIP of 1.211 and being the owner of a FIP of 3.6. His strikeout to walk ratio is 3.33 and he has gone up against 1,988 hitters in his career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Houston (-132)

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