Boston Red Sox vs Tampa Bay Rays Prediction, 9/21/2025 MLB Picks, Best Bets & Odds

Game: Boston Red Sox vs Tampa Bay Rays

Date: Sunday, September 21, 2025

Location: George M. Steinbrenner Field in Tampa, FL

TV: FanDuel Sports Network Sun

Odds/Point Spread: Boston (-130) Tampa Bay (+110)

The Tampa Bay Rays (75-78) are welcoming the Boston Red Sox (83-70) at George M. Steinbrenner Field on Sunday. The moneyline on this contest has the Red Sox at -130 and the Rays are priced at +110. The over/under has been set at 8. The expected starting pitchers will be Kyle Harrison and Adrian Houser.

As a squad, the Boston Red Sox are notching 4.9 runs per outing, which has them sitting at 6th in the league. They have tallied 745 runs and hold an OBP of .323. The Red Sox have tallied 304 doubles as a team and have hit 180 baseballs out of the park. They have recorded 710 runs batted in and 1,333 base knocks for the season, and their batting average is sitting at .254. Boston has a slugging rate of .423 and have been called out on strikes 1,337 times, while being walked on 490 occasions.

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Their strikeout to walk ratio is 2.58 and the pitching staff sits with a WHIP of 1.29. Red Sox pitchers have allowed 156 long balls and 643 runs in total (11th in baseball). Boston has given up 1,270 base hits (8.3 per 9 innings) as well as 566 earned runs. The Red Sox hold a team ERA of 3.72 this year (4th in MLB), and their staff has struck out 1,282 batters. Their pitching staff has walked 497 players from the other team and their FIP comes in at 4.00 as a squad over the course of the season.

The Red Sox have sent 506 relief pitchers to the hill on the year. The relief pitchers have inherited 207 base runners on the season and 32.4% of them earned a run for their team. They have recorded 42 saves for the season and have missed out on 27 of 69 save chances. The Red Sox relievers have recorded a save rate of 60.9% and have stepped onto the mound in 151 save situations. The relievers have tallied 80 holds on the season (18th in the league). Red Sox relief pitchers have entered the game with runners on base 151 times in addition to having 182 appearances in high leverage situations.

The Red Sox have converted 69.0% of baseballs in play into outs in their 12,243 innings, which has them sitting at 23rd in MLB. The Baltimore Orioles have amassed 4,081 putouts on the year, in addition to 1,372 assists and 108 errors. Their fielding percentage is holding steady at .981 which ranks 30th in the majors, and have earned 122 double plays.

Harrison has pitched in 185 frames and is sitting with 180 K's so far in his pro baseball career. His ERA is 4.42 (91 ER's allowed) and his WHIP is 1.296. He has surrendered 178 base knocks (8.7 hits per nine innings) with 62 free passes. Harrison (9-9 record in his career) is the owner of a FIP of 4.36 and he has gone up against 792 opposing hitters in the majors.

Tampa Bay has tallied 173 home runs so far this season to go along with 647 RBIs. They have hit 231 two-baggers, while walking 439 times as well as scoring 679 runs. The Tampa Bay Rays have an OBP of .314 in addition to a batting average of .252 for the year. The Rays have a SLG% of .403 and they are scoring 4.44 runs per contest (14th in the league). They have been rung up on 1,311 occasions (11th in the league) and have a total of 1,300 base knocks.

The Rays have a team WHIP of 1.203 in addition to having a FIP of 4.14 as a unit on the season. Their strikeout to walk ratio sits at 8.90 (1,335 strikeouts against 438 bases on balls). They are currently ranked 7th in the league as a staff in total hits given up with 1,192. They have surrendered 193 dingers and they relinquish 4.16 runs per 9 innings (9th in the league). The Tampa Bay pitching staff have surrendered 627 runs this season while holding an ERA of 3.83 (577 earned runs given up).

Tampa Bay bullpen pitchers hold an inherited score percentage of 31.2% of 157 inherited base runners. Their relief pitchers have stepped onto the hill 151 times in high leverage situations in addition to 107 occasions with runners on base. Sitting with 148 save situations, the Rays have accumulated 84 holds and also 27 blown saves. They are currently ranked 26th in MLB with a save rate of 56.5%, and they have dispatched 491 relievers to the mound for the year. Tampa Bay has had bullpen pitchers step onto the hill in 62 save opportunities and they have earned 35 saves.

In 12,117 innings on the diamond, the Rays hold a defensive efficiency of 70.8% (6th in baseball). The Tampa Bay Rays have turned 138 double plays and have earned a fielding percentage of .987 (11th in MLB). The Rays have 1,331 assists, 72 errors and are sitting with 4,039 putouts for the season.

So far in his pro baseball career, Houser has allowed 704 base hits and he has 569 strikeouts in 721 innings pitched. He has given up a total of 324 earned runs while earning a WHIP of 1.360 and a FIP of 4.0. He has a strikeout to walk ratio of 2.05 and he has faced 3,085 hitters during his pro baseball career. Houser (40-43 career win-loss mark) has a 4.04 earned run average and has allowed 8.8 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Boston (-130)

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