Chicago Cubs vs Chicago White Sox Prediction, 7/25/2025 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs Chicago White Sox

Date: Friday, July 25, 2025

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: Chicago (-275) Chicago (+220)

Rate Field is the location where the Chicago White Sox (37-66) will try to defeat the Chicago Cubs (60-42) on Friday. The odds on this game have Chicago at -275 and Chicago is coming in at +220. The over/under comes in at 9. The pitchers taking the mound will be Shota Imanaga and Adrian Houser.

The Cubs have recorded 173 two-baggers as a squad and have smacked 152 balls out of the park. Chicago has a slugging percentage of .446 and have been called out on strikes 784 times, while drawing a walk on 346 occasions. As a team, the Chicago Cubs are earning 5.3 runs per outing, which is 2nd in baseball. They have recorded 525 RBI's in addition to 899 base knocks this year, and their average at the plate sits at .256. They have 537 runs while having a team on-base percentage of .324.

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Their strikeout to walk ratio is 2.81 and their pitching staff has a team WHIP of 1.22. Cubs pitchers have surrendered 128 home runs and 420 runs in total (12th in baseball). Chicago has surrendered 841 base knocks (8.3 per 9 innings) as well as 390 earned runs. The Cubs have a team ERA of 3.86 on the season (13th in baseball), and their staff has rung up 764 batters. They have walked 272 opposing hitters and their FIP comes in at 4.25 as a team for the year.

The Cubs have sent 335 relief pitchers to the mound for the season. The relief pitchers have inherited 96 base runners on the campaign and 29.2% of those players ended up crossing the plate. They have compiled 24 saves so far this season and have blown 11 of their 35 save opportunities. The Cubs relief pitchers have earned a save percentage of 68.6% and have entered the game in 101 save situations. The bullpen have 63 holds for the year (10th in baseball). Cubs relief pitchers have gone to the mound with players on base 70 times as well as having 100 appearances in high leverage situations.

The Cubs have turned 71.4% of baseballs in play into outs out of 8,187 innings, which has them sitting at 3rd in pro baseball. The Boston Red Sox are sitting with 2,729 putouts at this point in the season, in addition to 864 assists and 42 errors. Their fielding percentage is currently at .988 which has them ranked 5th in the majors, and have accumulated 83 double plays.

Imanaga has taken the ball for 248 innings and has earned 227 strikeouts during his career. Imanaga (22-6 mark in his career) sits with a FIP of 2.72 and he has faced 985 opposing hitters in the majors. His earned run average is 2.76 (76 ER's allowed) and he has a WHIP of 0.992. He has surrendered 201 hits (7.3 hits per 9 innings) with 45 free passes.

The Chicago White Sox have accounted for an OBP of .298 in addition to a batting average of .224 on the year. They have been rung up on 881 occasions (9th in baseball) and have notched a total of 756 base hits. Chicago has recorded 85 home runs this year and 365 RBIs. The White Sox hold a team SLG% of .354 and they are recording 3.70 runs per game (27th in MLB). They have put up 166 two-baggers, while walking 340 times as well as putting up 381 runs.

The White Sox hold a team WHIP of 1.378 and have a FIP of 4.45 as a unit on the year. They are currently ranked 19th in MLB as a staff in total hits given up with 857. The Chicago pitching staff have conceded 453 runs on the year while holding an ERA of 4.08 (406 earned runs surrendered). Their strikeout to walk ratio sits at 7.50 (751 strikeouts vs 378 bases on balls). They have conceded 109 homers and they allow 4.55 runs per 9 innings (21st in the league).

Chicago has called on relievers to enter the game in 29 save opportunities and they have walked away with 13 saves. They are currently ranked 30th in baseball holding a save rate of 44.8%, and they have sent 324 relief pitchers to the mound this year. Their bullpen pitchers have taken the field 91 times in high leverage situations in addition to 93 occasions with runners on. Chicago relief pitchers hold an inherited score percentage of 29.4% of 136 inherited runners. With 72 save situations, the White Sox have recorded 43 holds in addition to 16 blown saves.

The Chicago White Sox have turned 88 double plays and own a fielding percentage of .983 (25th in the majors). The White Sox have 857 assists, 63 errors and have 2,690 putouts on the campaign. Out of their 8,070 innings on the diamond, the White Sox have a efficiency on defense of 69.7% (16th in MLB).

During his career, Houser has allowed 651 hits while tallying 528 punch outs in 670 frames. He has given up 298 ER's while holding a WHIP of 1.364 and being the owner of a FIP of 3.9. He has a strikeout to walk ratio of 2.01 and he has gone up against 2,867 opposing hitters thus far in his career. Houser (37-41 win-loss mark in his career) is the owner of a 4.00 earned run average and has given up 8.7 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (+220)

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