Chicago Cubs vs Chicago White Sox Prediction, 7/26/2025 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs Chicago White Sox

Date: Saturday, July 26, 2025

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: Chicago (-144) Chicago (+120)

Rate Field is the location where the Chicago White Sox (37-66) will compete against the Chicago Cubs (60-42) on Saturday. The odds on this game have Chicago at -144 while Chicago is sitting at +120. The betting total comes in at 9. The men taking the mound will be Cade Horton and Aaron Civale.

As a unit, the Chicago Cubs are putting up 5.3 runs/g, which is 2nd in MLB. They are sitting with 537 runs scored while holding a team OBP of .324. The Cubs have compiled 173 two-baggers as a team and have knocked 152 baseballs out of the park. They have 525 runs batted in as well as 899 base knocks for the season, while their batting average is .256. Chicago has a slugging percentage of .446 and have been called out on strikes 784 times, while drawing a walk on 346 occasions.

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Their K/BB ratio is 2.81 and the pitching staff has recorded a WHIP of 1.22. Cubs pitchers have allowed 128 home runs and also 420 runs (12th in MLB). Chicago has yielded 841 hits (8.3 per 9 innings) and 390 earned runs. The Cubs are sitting with a team earned run average of 3.86 this season (13th in the league), and the staff has struck out 764 hitters. They have walked 272 opposing batters and their FIP comes in at 4.25 as a team so far this year.

Cubs pitchers have stepped onto the hill with runners on 70 times and also have had 100 appearances in high leverage situations. The relievers have tallied 63 holds over the course of the season (10th in baseball). The Cubs bullpen have a save percentage of 68.6% and have entered the game in 101 save situations. They have compiled 24 saves over the course of the season and have missed out on 11 out of their 35 save opportunities. The bullpen pitchers have inherited 96 base runners on the campaign with 29.2% of them crossed the plate. The Cubs have dispatched 335 relief pitchers to the hill over the course of the season.

The Boston Red Sox have notched a total of 2,729 putouts this season, in addition to 864 assists and 42 errors. Their fielding rate sits at .988 which has them ranked 5th in MLB, and have accumulated 83 double plays. The Cubs have converted 71.4% of balls in play into outs out of 8,187 innings on the diamond, which ranks them 3rd in MLB.

Horton has thrown 62 frames and has earned 47 K's during his pro baseball career. Horton (3-3 career win-loss mark) has earned a FIP of 4.00 and he has faced 267 opposing hitters during his time in the majors. His earned run average is 4.06 (28 earned runs allowed) and his career WHIP is 1.369. He has surrendered 64 base knocks (9.3 hits per nine innings) and has 21 free passes.

The White Sox hold a slugging percentage of .354 and they have an average of 3.70 runs per game (27th in MLB). They have hit 166 doubles, while walking 340 times as well as putting up 381 runs. Chicago has hit 85 long balls on the season and 365 runs batted in. They have struck out on 881 occasions (9th in baseball) and are sitting with 756 hits. The Chicago White Sox have compiled an on-base percentage of .298 as well as a batting average of .224 so far this season.

The White Sox have a team WHIP of 1.378 with a FIP of 4.45 as a pitching staff for the year. They are currently ranked 19th in MLB as a pitching staff in total hits relinquished with 857. The Chicago pitching staff have allowed 453 runs for the season while holding an ERA of 4.08 (406 earned runs allowed). Their strikeout to walk ratio sits at 7.50 (751 strikeouts vs 378 walks). They have allowed 109 dingers and they relinquish 4.55 runs per 9 innings (21st in MLB).

With 72 save situations, the White Sox have compiled 43 holds in addition to 16 blown saves. Chicago has had bullpen pitchers take the mound in 29 save chances and they have converted 13 saves. Their relief pitchers have stepped onto the mound 91 times in high leverage situations and on 93 occasions with runners on. Chicago relievers hold an inherited score rate of 29.4% out of 136 inherited runners. They are currently ranked 30th in MLB with a save rate of 44.8%, and they have sent 324 relief pitchers onto the diamond over the course of the season.

In 8,070 innings on the diamond, the White Sox have accumulated a defensive efficiency of 69.7% (16th in MLB). The Chicago White Sox have turned 88 double plays and hold a fielding percentage of .983 (25th in the majors). The White Sox have recorded 857 assists, 63 errors and have notched a total of 2,690 putouts during this campaign.

In his MLB career, Civale has conceded 653 hits while earning 619 K's in 694 frames. Civale (41-41 career win-loss record) has earned a 4.10 earned run average while giving up 8.5 hits per nine innings. He has surrendered a total of 316 ER's while earning a WHIP of 1.218 and a FIP of 4.0. He has a K/BB ratio of 3.21 and he has gone up against 2,893 batters thus far in his career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (+120)

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