Chicago Cubs vs Chicago White Sox Prediction, 7/27/2025 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs Chicago White Sox

Date: Sunday, July 27, 2025

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: Chicago (-275) Chicago (+220)

Rate Field is the site where the Chicago White Sox (37-66) will go up against the Chicago Cubs (60-42) on Sunday. The odds on this game have Chicago at -275 and Chicago is sitting at +220. The total has been set at 9. The expected starting pitchers will be Ben Brown and Sean Burke.

As a unit, the Chicago Cubs are earning 5.3 runs per game, which ranks them 2nd in the league. They have accounted for 537 runs while holding a team OBP of .324. The Cubs have tallied 173 doubles as a team and have knocked 152 baseballs out of the park. They have accumulated 525 RBI's in addition to 899 base knocks on the season, while their average at the plate sits at .256. Chicago is slugging .446 and have been called out on strikes 784 times, while being walked on 346 occasions.

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They have earned a K/BB ratio of 2.81 and their pitching staff has a collective WHIP of 1.22. Cubs pitchers have given up 128 long balls in addition to 420 runs (11th in the league). Chicago has surrendered 841 hits (8.3 per 9 innings) as well as 390 earned runs. The Cubs are sitting with a team ERA of 3.86 so far this season (13th in baseball), and their staff has rung up 764 hitters. They have walked 272 opposing batters and their FIP comes in at 4.25 as a squad on the campaign.

The Cubs have sent 335 relievers to the mound this year. The bullpen pitchers have inherited 96 runners on the campaign and 29.2% of them ended up crossing the plate. They have accumulated 24 saves so far this year and have not converted 11 of 35 save opportunities. The Cubs relief pitchers have recorded a save percentage of 68.6% and have stepped onto the mound in 101 save situations. The relievers are sitting with 63 holds this season (10th in MLB). Cubs relief pitchers have entered the game with runners on 70 times as well as having 100 appearances in high leverage situations.

The Boston Red Sox have earned a total of 2,729 putouts this season, in addition to 864 assists and 42 errors. Their fielding percentage is holding steady at .988 which has them ranked 5th in professional baseball, and they have turned 83 double plays. The Cubs have converted 71.4% of balls hit into play into outs out of their 8,187 innings on the diamond, which ranks them 3rd in professional baseball.

Brown (5-10 career mark) sits with a FIP of 5.26 while he has faced 600 opposing batters during his time in the majors. He has surrendered 142 base hits (9.2 hits per nine innings) and has had 46 walks. His earned run average is 5.34 (82 earned runs allowed) and he has a career WHIP of 1.360. Brown has thrown 138 innings and has 159 K's so far in his pro baseball career.

The White Sox have a team slugging % of .354 and they score 3.70 runs per contest (27th in MLB). They have put up 166 doubles, while taking a walk 340 times as well as putting up 381 runs. Chicago has knocked in 85 home runs over the course of the season to go along with 365 runs batted in. They have been rung up on 881 occasions (10th in the league) and are sitting with 756 base knocks. The Chicago White Sox have recorded an OBP of .298 in addition to a batting average of .224 this season.

The White Sox have a WHIP of 1.378 and have a FIP of 4.45 as a team on the campaign. They rank 19th in MLB as a pitching staff in total hits allowed with 857. The Chicago pitching staff have conceded 453 runs over the course of the season while holding an ERA of 4.08 (406 earned runs conceded). They currently have a strikeout to walk ratio of 7.50 (751 strikeouts vs 378 free passes). They have given up 109 long balls and they surrender 4.55 runs per 9 innings (21st in MLB).

Sitting with 72 save situations, the White Sox have 43 holds in addition to 16 blown saves. Chicago has called on relievers to enter the game in 29 save opportunities and they have tallied 13 saves. Their bullpen pitchers have taken the field 91 times in high leverage situations and also on 93 occasions with base runners. Chicago relievers have an inherited score percentage of 29.4% of 136 inherited base runners. They sit at 30th in baseball holding a save percentage of 44.8%, and they have dispatched 324 bullpen pitchers to the mound on the campaign.

Out of their 8,070 innings on the diamond, the White Sox have a efficiency on defense of 69.7% (16th in baseball). The Chicago White Sox have turned 88 double plays and have a fielding percentage of .983 (25th in MLB). The White Sox have racked up 857 assists, 63 errors and have a tally of 2,690 putouts during this campaign.

Burke (6-8 career record) is the owner of a 3.75 ERA and has allowed 8.1 hits per 9 innings. He has a strikeout to walk ratio of 1.98 and he has faced 520 batters during his career. He has allowed a total of 50 earned runs while earning a WHIP of 1.350 and being the owner of a FIP of 3.7. So far in his career, Burke has conceded 108 hits and he has 107 punch outs in 120 frames.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (+220)

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