Chicago Cubs vs Cincinnati Reds Prediction, 5/25/2025 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs Cincinnati Reds

Date: Sunday, May 25, 2025

Location: Great American Ball Park in Cincinnati, OH

TV: FanDuel Sports Network Ohio

Odds/Point Spread: Chicago (-128) Cincinnati (+106)

The Chicago Cubs (30-20) are traveling to Great American Ball Park on Sunday where they will try to defeat the Cincinnati Reds (25-26). The moneyline on this contest has Chicago at -128 while Cincinnati is opening at +106. The total comes in at 8. The pitchers taking the mound are Ben Brown and Nick Lodolo.

Chicago has a slugging percentage of .447 and have struck out 398 times, while being walked on 190 occasions. They have amassed 286 runs batted in in addition to 455 base knocks on the year, while their team batting average sits at .261. The Cubs have accumulated 93 doubles as a squad and have hit 69 baseballs out of the stadium. They have 293 runs scored and have an on-base percentage of .335. As a team, the Chicago Cubs are recording 5.9 runs per game, which ranks them 1st in the league.

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They have a K/BB ratio of 2.61 and the pitching staff holds a collective WHIP of 1.28. Cubs pitchers have surrendered 60 long balls and also 210 total runs (17th in the league). Chicago has allowed 421 base hits (8.5 per 9 innings) in addition to 194 earned runs. The Cubs hold a team ERA of 3.90 this season (16th in the league), and their staff has struck out 394 hitters. They have walked 151 hitters and their FIP comes in at 4.19 as a team so far this year.

Cubs bullpen pitchers have stepped onto the hill with opponents on base 38 times and also have had 53 appearances in high leverage situations. The relief pitchers have tallied 32 holds so far this year (9th in the league). The Cubs relievers have accumulated a save percentage of 57.9% and have come into the game in 52 save situations. They have recorded 11 saves on the campaign and have blown 8 of their 19 chances to get a save. The relief pitchers have inherited 53 runners for the season and 35.8% of them ended up scoring. The Cubs have dispatched 171 relievers to the hill on the campaign.

The Boston Red Sox have 1,343 putouts for the season, in addition to 419 assists and 24 errors. Their fielding rate is at .987 which ranks 12th in baseball, and have earned 44 double plays. The Cubs have converted 70.3% of baseballs in play into outs out of their 4,029 innings on the field, which has them sitting at 15th in professional baseball.

Brown (4-6 career win-loss record) has earned a FIP of 4.38 and he has faced 434 batters in the major leagues. He has allowed 97 hits (8.6 hits per nine innings) and has had 35 free passes. His earned run average is 4.45 (50 ER's allowed) and he has a WHIP of 1.304. Brown has taken the ball for 101 innings and is sitting with 122 K's so far in his pro baseball career.

The Reds have a SLG% of .391 and they are earning 4.47 runs per contest (11th in MLB). They have 89 two-baggers, while taking a walk 175 times as well as earning 228 runs. Cincinnati has compiled 53 home runs so far this season as well as 220 runs batted in. They have struck out on 457 occasions (4th in the league) and have a total of 412 hits. The Cincinnati Reds have an OBP of .317 and a team batting average of .241 for the season.

The Reds have a team WHIP of 1.168 in addition to having a FIP of 3.97 as a squad on the campaign. They have earned a K/BB ratio of 8.30 (418 strikeouts against 154 free passes). They are sitting at 6th in baseball as a staff in total hits allowed with 374. They have given up 55 home runs and they relinquish 3.88 runs per 9 innings (9th in MLB). The Cincinnati pitching staff have surrendered 195 runs this season while holding an ERA of 3.48 (175 earned runs given up).

Cincinnati relievers have an inherited score rate of 29.6% out of their 54 inherited runners. Their bullpen pitchers have come in 47 times in high leverage situations and on 35 occasions with runners on base. Sitting with 62 save situations, the Reds have tallied 40 holds in addition to 6 blown saves. They are ranked 5th in baseball holding a save rate of 70.0%, and they have dispatched 171 bullpen pitchers onto the field this year. Cincinnati has had relief pitchers step onto the hill in 20 save opportunities and they have earned 14 saves.

Out of their 4,068 innings on the diamond, the Reds are sitting with a defensive efficiency of 72.7% (3rd in the majors). The Cincinnati Reds have gotten 27 double plays and have a fielding percentage of .985 (18th in MLB). The Reds have accrued 397 assists, 26 errors and have accumulated 1,356 putouts on the campaign.

During his pro baseball career, Lodolo has given up 293 base hits while accumulating 349 strikeouts in 311 frames. Lodolo (19-18 mark in his career) is the owner of a 4.28 earned run average while surrendering 8.5 hits per 9 innings. He has allowed a total of 148 ER's while earning a WHIP of 1.250 and being the owner of a FIP of 4.2. His strikeout to walk ratio is 3.64 and he has faced 1,345 batters during his career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (-128)

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