Chicago Cubs vs Cincinnati Reds Prediction, 9/18/2025 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs Cincinnati Reds

Date: Thursday, September 18, 2025

Location: Great American Ball Park in Cincinnati, OH

TV: FanDuel Sports Network Ohio

Odds/Point Spread: Chicago (-145) Cincinnati (+125)

Great American Ball Park is the location where the Cincinnati Reds (75-76) will meet the Chicago Cubs (87-64) on Thursday. The odds on this game have Chicago at -145 while Cincinnati opens at +125. The total comes in at 9. The pitchers taking the mound are Colin Rea and Hunter Greene.

The Cubs have hit 250 two-baggers as a unit and have smacked 203 baseballs out of the park. Chicago has a slugging rate of .428 and have been called out on strikes 1,184 times, while drawing a walk on 521 occasions. As a team, the Chicago Cubs are scoring 4.9 runs per contest, which has them sitting at 8th in the league. They have accumulated 717 RBI's and 1,281 hits over the course of the season, and their team batting average is at .250. They are sitting with 735 runs scored while holding a team OBP of .321.

Get all of our Free MLB Picks

The Cubs hold a team ERA of 3.81 so far this season (7th in MLB), and the staff has rung up 1,164 hitters. Cubs pitchers have yielded 184 long balls in addition to 606 total runs (5th in MLB). They have walked 383 players from the other team and their FIP sits at 4.17 as a unit for the year. Chicago has conceded 1,207 hits (8.1 per 9 innings) as well as 568 earned runs. Their strikeout to walk ratio is 3.04 and the pitching staff has a team WHIP of 1.19.

The Cubs bullpen have recorded a save percentage of 68.9% and have stepped onto the mound in 170 save situations. The relievers have inherited 135 runners so far this year and 32.6% of them crossed the plate. Cubs pitchers have entered the game with runners on 96 times and also have had 153 appearances in high leverage situations. The Cubs have dispatched 492 relievers to the hill this year. The relief pitchers have earned 106 holds on the campaign (2nd in MLB). They have accumulated 42 saves on the season and have not converted 19 out of their 61 chances to get a save.

The Cubs have converted 71.7% of balls in play into outs in their 12,060 innings on the diamond, which has them sitting at 3rd in baseball. The Boston Red Sox have 4,020 putouts this season, in addition to 1,269 assists and 57 errors. Their fielding rate is holding at .989 which has them sitting 4th in professional baseball, and have a total of 115 double plays.

Rea has taken the mound for 592 innings and has racked up 475 strikeouts in his career. Rea (36-26 win-loss record in his career) sits with a FIP of 4.43 and he has faced 2,521 opposing batters in the majors. His earned run average is 4.50 (296 ER's allowed) and he has a WHIP of 1.286. He has surrendered 581 hits (8.8 hits per nine innings) and has 181 walks.

The Cincinnati Reds have accumulated an on-base percentage of .316 as well as a team batting average of .245 so far this season. They have struck out on 1,312 occasions (9th in the league) and have a total of 1,248 base hits. Cincinnati has hit 152 home runs this season to go along with 639 runs batted in. The Reds hold a slugging percentage of .391 and they are earning 4.48 runs per outing (13th in the league). They have 237 two-baggers, while walking 497 times and scoring 676 runs.

The Reds hold a team WHIP of 1.243 with a FIP of 4.19 as a unit over the course of the season. Their strikeout to walk ratio comes in at 8.60 (1,276 strikeouts against 465 free passes). They come in at 8th in the league as a staff in total hits given up with 1,194. They have given up 182 homers and they allow 4.41 runs per 9 innings (16th in MLB). The Cincinnati pitching staff have surrendered 654 runs this year while holding an ERA of 3.99 (592 earned runs surrendered).

With 151 save situations, the Reds have 91 holds in addition to 22 blown saves. Cincinnati has called on relievers to step onto the hill in 57 save chances and they have walked away with 35 saves. Their relievers have stepped onto the mound 158 times in high leverage situations in addition to 138 occasions with runners on base. Cincinnati bullpen pitchers hold an inherited score rate of 33.5% out of 206 inherited base runners. They are currently ranked 19th in the league holding a save percentage of 61.4%, and they have sent 514 bullpen pitchers onto the field on the campaign.

The Cincinnati Reds have gotten 95 double plays and have a fielding rate of .984 (23rd in the majors). The Reds have 1,160 assists, 83 errors and have 4,005 putouts this year. In 12,015 innings on the field, the Reds are sitting with a defensive efficiency of 70.8% (5th in pro baseball).

In his MLB career, Greene has given up 380 base knocks while tallying 601 K's in 480 innings. He has given up a total of 199 ER's while holding a WHIP of 1.158 and having a FIP of 3.7. He has a K/BB ratio of 3.41 and he has faced 2,007 hitters in his MLB career. Greene (24-29 win-loss record in his career) has earned a 3.73 ERA and has conceded 7.1 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Chicago (-145)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here