Chicago Cubs vs Cincinnati Reds Prediction, 9/19/2025 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs Cincinnati Reds

Date: Friday, September 19, 2025

Location: Great American Ball Park in Cincinnati, OH

TV: FanDuel Sports Network Ohio

Odds/Point Spread: Chicago (-182) Cincinnati (+150)

Great American Ball Park is the site where the Cincinnati Reds (76-76) will take on the Chicago Cubs (88-64) on Friday. The odds on this game have the Cubs at -182 while the Reds are coming in at +150. The over/under is 8. The expected starting pitchers will be Shota Imanaga and Nick Lodolo.

Chicago has a slugging % of .428 and have struck out 1,190 times, while taking a walk on 528 occasions. They have compiled 724 RBI's as well as 1,291 base knocks on the campaign, and their average at the plate is at .250. The Cubs have accounted for 251 two-baggers as a squad and have hit 205 baseballs out of the park. They have accounted for 743 runs scored and have an OBP of .322. As a unit, the Chicago Cubs are recording 4.9 runs per outing, which has them sitting at 6th in MLB.

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The Cubs have compiled a team earned run average of 3.82 on the year (7th in the league), and their staff has struck out 1,175 batters. Cubs pitchers have yielded 185 home runs and also 610 runs in total (5th in the league). They have walked 386 players from the other team and their FIP sits at 4.16 as a squad so far this year. Chicago has given up 1,217 hits (8.1 per 9 innings) in addition to 572 earned runs. Their K/BB ratio is 3.04 and their pitching staff has earned a collective WHIP of 1.19.

Cubs relief pitchers have entered the contest with runners on base 96 times and also have had 153 appearances in high leverage situations. The bullpen have notched 106 holds so far this season (2nd in MLB). The Cubs bullpen have recorded a save percentage of 68.9% and have come into the game in 170 save situations. They have compiled 42 saves so far this season and have blown 19 of their 61 save opportunities. The relievers have inherited 135 runners for the season and 32.6% of those players ended up crossing the plate. The Cubs have dispatched 496 relievers to the hill for the year.

The Cubs have converted 71.7% of balls hit into play into outs in their 12,141 innings on the field, which has them ranked 3rd in MLB. The Boston Red Sox have accounted for 4,047 putouts on the year, as well as 1,274 assists and 58 errors. Their fielding percentage is holding at .989 which is 5th in baseball, and they have turned 115 double plays.

Imanaga has taken the mound for 307 frames and has earned 284 strikeouts so far in his pro baseball career. Imanaga (24-10 career win-loss record) is the owner of a FIP of 3.03 while he has faced 1,215 opposing hitters in the majors. His earned run average is 3.08 (105 ER's allowed) and his WHIP is 0.990. He has given up 253 base knocks (7.4 hits per nine innings) and has 51 walks.

The Reds have a team slugging % of .391 and they average 4.49 runs per game (13th in MLB). They have recorded 238 doubles, while getting a free base 500 times and putting up 682 runs. Cincinnati has compiled 153 home runs so far this year and 644 runs batted in. They have been called out on strikes on 1,321 occasions (9th in MLB) and have tallied 1,259 base hits. The Cincinnati Reds have compiled an OBP of .316 and a batting average of .246 so far this year.

The Reds hold a team WHIP of 1.241 and have a FIP of 4.19 as a squad for the season. They are currently ranked 8th in the league as a pitching staff in total hits allowed with 1,199. The Cincinnati pitching staff have relinquished 656 runs so far this year while holding an ERA of 3.97 (593 earned runs conceded). They have earned a strikeout to walk ratio of 8.60 (1,287 strikeouts vs 469 walks). They have surrendered 183 long balls and they concede 4.39 runs per 9 innings (16th in the league).

Cincinnati bullpen pitchers have an inherited score percentage of 33.3% out of their 207 inherited runners. Their relief pitchers have come in 159 times in high leverage situations and on 139 occasions with runners on base. With 152 save situations, the Reds have tallied 92 holds and also 22 blown saves. They rank 19th in the league with a save percentage of 61.4%, and they have dispatched 517 bullpen pitchers to the hill for the year. Cincinnati has called on bullpen pitchers to enter the contest in 57 save chances and they have earned 35 saves.

In 12,096 innings on the diamond, the Reds have accumulated a efficiency on defense of 70.9% (5th in baseball). The Cincinnati Reds have gotten 96 double plays and hold a fielding percentage of .984 (23rd in the majors). The Reds have accrued 1,166 assists, 84 errors and have accumulated 4,032 putouts for the year.

Lodolo (23-22 career mark) has a 4.08 ERA while giving up 8.3 hits per 9 innings. His K/BB ratio is 3.90 and he has gone up against 1,690 hitters so far in his pro baseball career. He has allowed 180 earned runs while earning a WHIP of 1.203 and having a FIP of 4.0. In his MLB career, Lodolo has conceded 366 hits and he has 437 punch outs in 397 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Cincinnati (+150)

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