Chicago Cubs vs Cincinnati Reds Prediction, 9/20/2025 MLB Picks, Best Bets & Odds
Game: Chicago Cubs vs Cincinnati Reds
Date: Saturday, September 20, 2025
Location: Great American Ball Park in Cincinnati, OH
TV: FanDuel Sports Network Ohio
Odds/Point Spread: Chicago (-144) Cincinnati (+120)
The Cincinnati Reds (76-76) welcome the Chicago Cubs (88-64) at Great American Ball Park on Saturday. The moneyline on this matchup has Chicago at -144 and Cincinnati is at +120. The over/under is 8.5. The pitchers who are expected to start will be Javier Assad and Zack Littell.


Chicago has a slugging % of .428 and have struck out 1,190 times, while taking a walk on 528 occasions. They have tallied 724 RBI's in addition to 1,291 base knocks this year, while their team batting average sits at .250. The Cubs have tallied 251 doubles as a unit and have knocked 205 baseballs out of the stadium. They have tallied 743 runs and hold an OBP of .322. As a unit, the Chicago Cubs are compiling 4.9 runs per game, which has them at 6th in the league.
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Their K/BB ratio is 3.04 and the pitching staff holds a WHIP of 1.19. Cubs pitchers have relinquished 185 long balls and also 610 runs in total (5th in MLB). Chicago has allowed 1,217 base hits (8.1 per 9 innings) as well as 572 earned runs. The Cubs have compiled a team earned run average of 3.82 so far this season (7th in baseball), and the staff has rung up 1,175 batters. Their pitching staff has walked 386 batters and their FIP is 4.16 as a unit for the year.
Cubs pitchers have come into the game with runners on 96 times and also have had 153 appearances in high leverage situations. The relievers have notched 106 holds so far this season (2nd in the league). The Cubs relief pitchers have earned a save rate of 68.9% and have entered the game in 170 save situations. They have recorded 42 saves over the course of the season and have missed out on 19 of their 61 save chances. The relievers have inherited 135 runners over the course of the season and 32.6% of those runners crossed home plate. The Cubs have dispatched 496 relief pitchers to the hill so far this season.
The Cubs have converted 71.7% of balls hit into play into outs out of their 12,141 innings on the diamond, which ranks them 3rd in baseball. The Boston Red Sox have a tally of 4,047 putouts on the year, as well as 1,274 assists and 58 errors. Their fielding percentage is at .989 which ranks 5th in pro baseball, and they have turned 115 double plays.
Assad has taken the mound for 321 innings and has accumulated 263 strikeouts so far in his pro baseball career. Assad (17-12 win-loss record in his career) holds a FIP of 3.42 while he has gone up against 1,369 hitters in the major leagues. His ERA is 3.47 (124 earned runs allowed) and he has a WHIP of 1.342. He has given up 298 base knocks (8.3 hits per 9 innings) with 133 walks.
The Cincinnati Reds have accumulated an OBP of .316 and a batting average of .246 this year. They have struck out on 1,321 occasions (9th in MLB) and have totaled 1,259 base hits. Cincinnati has compiled 153 HRs on the season to go along with 644 RBIs. The Reds have a team slugging percentage of .391 and they are recording 4.49 runs per contest (13th in the league). They have 238 doubles, while taking a walk 500 times as well as putting up 682 runs.
The Reds hold a team WHIP of 1.241 with a FIP of 4.19 as a unit so far this year. Their strikeout to walk ratio sits at 8.60 (1,287 strikeouts against 469 free passes). They are sitting at 8th in the league as a staff in total hits given up with 1,199. They have conceded 183 homers and they allow 4.39 runs per 9 innings (16th in the league). The Cincinnati pitching staff have given up 656 runs this season while having a team ERA of 3.97 (593 earned runs conceded).
Sitting with 152 save situations, the Reds have compiled 92 holds in addition to 22 blown saves. Cincinnati has called on relievers to enter the contest in 57 save chances and they have converted 35 saves. Their relievers have stepped onto the mound 159 times in high leverage situations in addition to 139 occasions with runners on base. Cincinnati bullpen pitchers hold an inherited score rate of 33.3% out of 207 inherited runners. They are currently ranked 19th in baseball with a save rate of 61.4%, and they have sent 517 relief pitchers to the mound this season.
In their 12,096 innings played, the Reds have earned a defensive efficiency of 70.9% (5th in MLB). The Cincinnati Reds have gotten 96 double plays and have a fielding percentage of .984 (23rd in baseball). The Reds have recorded 1,166 assists, 84 errors and have accumulated 4,032 putouts over the course of the season.
During his pro baseball career, Littell has conceded 591 hits while he has tallied 489 strikeouts in 593 frames. He has surrendered a total of 257 ER's while holding a WHIP of 1.219 and being the owner of a FIP of 3.8. His strikeout to walk ratio is 3.70 and he has gone up against 2,475 hitters in his career. Littell (33-29 career mark) holds a 3.90 earned run average while surrendering 9.0 hits per nine innings.
Who will win tonight's MLB game against the spread or moneyline?
Tony Sink's Pick: Take Cincinnati (+120)
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Additional Resources:
Cincinnati Reds - Twitter
Chicago Cubs - Twitter