Chicago Cubs vs Miami Marlins Prediction, 5/21/2025 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs Miami Marlins

Date: Wednesday, May 21, 2025

Location: loanDepot park in Miami, FL

TV: FanDuel Sports Network Florida

Odds/Point Spread: Chicago (-275) Miami (+220)

The Chicago Cubs (28-20) are headed to loanDepot park on Wednesday where they will meet the Miami Marlins (19-27). The moneyline on this game has the Cubs at -275 while the Marlins are sitting at +220. The over/under has been set at 9. The expected starting pitchers are Cade Horton and Max Meyer.

Chicago has a slugging rate of .442 and have been rung up 383 times, while drawing a walk on 186 occasions. They have accounted for 271 runs batted in and 426 base knocks this season, and their average at the plate comes in at .256. The Cubs have hit 87 doubles as a unit and have hit 66 baseballs out of the park. They have earned 277 runs scored while holding a team OBP of .332. As a team, the Chicago Cubs are recording 5.8 runs per contest, which has them sitting at 2nd in MLB.

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The Cubs have a team ERA of 4.02 this season (16th in the league), and they have rung up 389 hitters. Cubs pitchers have surrendered 59 home runs and 208 total runs (18th in the league). They have walked 144 opposing hitters and their FIP sits at 4.20 as a team so far this year. Chicago has given up 409 hits (8.6 per 9 innings) and 192 earned runs. They have accumulated a K/BB ratio of 2.70 and their pitching staff has earned a collective WHIP of 1.29.

The Cubs have sent 167 relievers to the hill for the year. The relievers have inherited 52 base runners for the season with 36.5% of those players crossed home plate. They have earned 10 saves over the course of the season and have blown 8 out of their 18 chances to get a save. The Cubs relievers have recorded a save rate of 55.6% and have stepped onto the mound in 51 save situations. The relievers have a total of 32 holds for the season (8th in MLB). Cubs pitchers have entered the contest with opponents on base 37 times in addition to having 51 appearances in high leverage situations.

The Cubs have converted 69.8% of balls in play into outs out of their 3,867 innings, which ranks them 17th in professional baseball. The Boston Red Sox have earned a total of 1,289 putouts at this point in the season, in addition to 393 assists and 24 errors. Their fielding percentage is at .986 which ranks 15th in pro baseball, and have earned 41 double plays.

Horton has taken the ball for 9 innings and has accumulated 7 punch outs so far in his pro baseball career. His earned run average is 6.00 (6 ER's allowed) and he has a career WHIP of 1.222. He has surrendered 11 hits (11.0 hits per 9 innings) and has 0 walks. Horton (2-0 career mark) holds a FIP of 5.91 while facing 39 hitters during his time in the major leagues.

The Marlins have a team slugging % of .391 and they earn 4.24 runs per contest (15th in the league). They have put up 76 two-baggers, while taking a walk 138 times as well as recording 195 runs. Miami has hit 44 long balls this season as well as 187 runs batted in. They have been rung up on 399 instances (13th in baseball) and have accounted for 391 hits. The Miami Marlins have earned a team OBP of .313 as well as a team batting average of .249 on the year.

The Miami pitching staff have relinquished 260 runs on the season while holding an ERA of 5.38 (244 earned runs surrendered). They have relinquished 58 HR's and they allow 5.73 runs per 9 innings (28th in MLB). The Marlins hold a team WHIP of 1.472 and are the owners of a FIP of 4.64 as a team this year. Their K/BB ratio comes in at 8.00 (364 strikeouts against 184 bases on balls). They come in at 25th in MLB as a staff in total hits given up with 417.

Miami has had relief pitchers step onto the mound in 15 save opportunities and they have walked away with 7 saves. They sit at 28th in MLB with a save percentage of 46.7%, and they have dispatched 157 relief pitchers to the mound on the season. Their relief pitchers have stepped onto the hill 53 times in high leverage situations and also on 47 occasions with runners on base. Miami relief pitchers hold an inherited score percentage of 34.8% out of their 66 inherited runners. Sitting with 38 save situations, the Marlins have 23 holds and 8 blown saves.

In 3,678 innings played, the Marlins have earned a defensive efficiency of 68.5% (23rd in professional baseball). The Miami Marlins have gotten 32 double plays and own a fielding percentage of .986 (13th in pro baseball). The Marlins have accrued 408 assists, 23 errors and have accumulated 1,226 putouts this year.

Meyer (6-10 career record) holds a 5.25 earned run average and has surrendered 9.5 hits per 9 innings. His strikeout to walk ratio is 3.00 and he has faced 490 opposing hitters in his career. He has surrendered 66 earned runs while earning a WHIP of 1.388 and having a FIP of 5.2. During his career, Meyer has allowed 120 base knocks while he has tallied 111 K's in 113 frames.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Chicago (-275)

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