Chicago Cubs vs Milwaukee Brewers Prediction, 10/6/2025 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs Milwaukee Brewers

Date: Monday, October 6, 2025

Location: American Family Field in Milwaukee, WI

TV: TBS

Odds/Point Spread: Chicago (+162) Milwaukee (-196)

The Milwaukee Brewers (97-65) will try to defeat the Chicago Cubs (92-70) at American Family Field on Monday in Game 2 of the NLDS. The Brewers won Game 1 by a score of 9-3 to take a 1-0 series lead. The moneyline on this game has the Cubs at +162 while the Brewers are coming in at -196. The betting total is set at 7.5. The men taking the mound are Shota Imanaga and Quinn Priester.

As a squad, the Chicago Cubs are scoring 4.9 runs per contest, which is 5th in the league. They have 793 runs and have an OBP of .320. The Cubs have hit 267 two-baggers as a team and have smacked 223 balls out of the park. They have accumulated 771 RBI's and 1,371 hits for the season, and their average at the plate sits at .249. Chicago owns a slugging percentage of .430 and have been rung up 1,277 times, while drawing a walk on 554 occasions.

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Their strikeout to walk ratio sits at 3.12 and the pitching staff holds a WHIP of 1.18. Cubs pitchers have relinquished 202 long balls in addition to 649 total runs (7th in the league). Chicago has surrendered 1,284 hits (8.1 per 9 innings) and also 605 earned runs. The Cubs are sitting with a team ERA of 3.79 on the year (8th in baseball), and their staff has rung up 1,265 hitters. They have walked 405 hitters and their FIP is 4.16 as a squad on the season.

The Cubs relievers have compiled a save rate of 68.8% and have stepped onto the mound in 177 save situations. The relief pitchers have inherited 142 base runners for the season and 33.8% of those runners crossed the plate. Cubs pitchers have stepped onto the hill with players on base 101 times as well as having 158 appearances in high leverage situations. The Cubs have dispatched 523 relievers to the mound on the season. The relief pitchers have recorded 110 holds on the campaign (3rd in baseball). They have earned 44 saves for the season and have blown 20 out of their 64 save opportunities.

The Cubs have converted 71.9% of balls in play into outs out of their 12,915 innings, which ranks them 2nd in the majors. The Boston Red Sox have accumulated 4,305 putouts at this point in the season, in addition to 1,342 assists and 61 errors. Their fielding percentage is holding at .989 which ranks 4th in the majors, and have a total of 117 double plays.

Imanaga (24-11 career win-loss record) is the owner of a FIP of 3.24 while he has gone up against 1,261 opposing batters during his time in the majors. He has surrendered 266 hits (7.5 hits per 9 innings) and has had 54 walks. His earned run average is 3.29 (116 ER's allowed) and he has a WHIP of 1.009. Imanaga has taken the ball for 317 innings and has tallied 291 strikeouts in his MLB career.

Milwaukee has knocked in 166 home runs on the campaign to go along with 750 RBIs. They have notched 265 doubles, while taking a walk 564 times and putting up 806 runs. The Milwaukee Brewers have compiled an OBP of .332 and a team batting average of .258 over the course of the season. The Brewers hold a team slugging % of .403 and they score 4.98 runs per game (3rd in MLB). They have been called out on strikes on 1,266 instances (26th in MLB) and are sitting with 1,423 base knocks.

The Brewers hold a team WHIP of 1.228 in addition to having a FIP of 3.91 as a pitching staff for the season. They have a ranking of 3rd in the league as a pitching staff in total hits relinquished with 1,237. The Milwaukee pitching staff have surrendered 634 runs on the campaign while having an ERA of 3.58 (574 earned runs surrendered). They have earned a strikeout to walk ratio of 8.90 (1,432 strikeouts vs 534 bases on balls). They have given up 168 homers and they concede 3.96 runs per 9 innings (3rd in MLB).

Sitting with 177 save situations, the Brewers have accumulated 107 holds in addition to 21 blown saves. Milwaukee has had bullpen pitchers enter the game in 66 save opportunities and they have walked away with 45 saves. Their relievers have taken the field 187 times in high leverage situations and also on 145 occasions with runners on. Milwaukee relief pitchers have an inherited score rate of 31.7% out of their 218 inherited base runners. They rank 5th in baseball with a save percentage of 68.2%, and they have dispatched 550 relief pitchers to the hill so far this year.

The Milwaukee Brewers have turned 122 double plays and hold a fielding percentage of .987 (10th in professional baseball). The Brewers have accrued 1,297 assists, 76 errors and have a tally of 4,326 putouts for the season. In 12,978 innings on the field, the Brewers hold a defensive efficiency of 70.9% (5th in professional baseball).

In his career, Priester has conceded 259 hits while totaling 201 strikeouts in 256 innings. Priester (19-12 win-loss record in his career) has a 4.46 earned run average and has given up 9.1 hits per 9 innings. He has given up a total of 127 earned runs while holding a WHIP of 1.366 and being the owner of a FIP of 4.4. His strikeout to walk ratio is 2.21 and he has gone up against 1,108 opposing batters during his career.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Milwaukee (-196) and under 8 runs

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