Chicago Cubs vs Milwaukee Brewers Prediction, Game 5 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs Milwaukee Brewers

Date: Saturday, October 11, 2025

Location: American Family Field in Milwaukee, WI

TV: TBS

Odds/Point Spread: Chicago (+162) Milwaukee (-196)

The Chicago Cubs (92-70) are on their way to American Family Field on Saturday where they will take on the Milwaukee Brewers (97-65) in Game 5 of the NLDS. The moneyline on this contest has the Cubs at +162 while the Brewers open at -196. The betting total comes in at 7. The pitchers who are expected to start are Shota Imanaga and Jacob Misiorowski, although both teams will be running 4 or 5 pitchers out there.

As a team, the Chicago Cubs are putting up 4.9 runs/g, which ranks them 5th in the league. They have accounted for 793 runs scored while having a team OBP of .320. The Cubs have accounted for 267 doubles as a unit and have smacked 223 balls out of the stadium. They have recorded 771 runs batted in as well as 1,371 hits this year, and their average at the plate is at .249. Chicago has a slugging % of .430 and have struck out 1,277 times, while being walked on 554 occasions.

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They have earned a K/BB ratio of 3.12 and their pitching staff has earned a collective WHIP of 1.18. Cubs pitchers have yielded 202 home runs and also 649 total runs (7th in MLB). Chicago has allowed 1,284 base hits (8.1 per 9 innings) and 605 earned runs. The Cubs have compiled a team earned run average of 3.79 for the year (8th in MLB), and the staff has rung up 1,265 batters. Their pitching staff has walked 405 batters and their FIP comes in at 4.16 as a squad so far this year.

The Cubs have dispatched 523 relievers to the mound so far this season. The relievers have inherited 142 runners so far this season with 33.8% of those players crossed home plate. They have tallied 44 saves for the year and have not converted 20 of 64 chances to save the game. The Cubs bullpen have recorded a save rate of 68.8% and stepped onto the hill in 177 save situations. The relief pitchers have earned 110 holds so far this season (3rd in the league). Cubs pitchers have entered the game with runners on 101 times as well as having 158 appearances in high leverage situations.

The Boston Red Sox have a total of 4,305 putouts at this point in the season, as well as 1,342 assists and 61 errors. Their fielding percentage is holding at .989 which has them sitting 4th in professional baseball, and they have turned 117 double plays. The Cubs have transformed 71.9% of balls hit into play into outs in their 12,915 innings, ranking them 2nd in baseball.

Imanaga has thrown 317 frames and is sitting with 291 strikeouts so far in his career. His ERA is 3.29 (116 ER's allowed) and he has a career WHIP of 1.009. He has given up 266 hits (7.5 hits per 9 innings) and has had 54 free passes. Imanaga (24-11 win-loss record in his career) is the owner of a FIP of 3.24 and he has gone up against 1,261 hitters in the major leagues.

The Brewers have a slugging percentage of .403 and they are earning 4.98 runs per outing (3rd in the league). They have tallied 265 doubles, while taking a walk 564 times as well as earning 806 runs. Milwaukee is sitting with 166 home runs so far this year to go along with 750 runs batted in. They have struck out on 1,266 instances (26th in MLB) and have recorded 1,423 hits. The Milwaukee Brewers hold an OBP of .332 as well as a batting average of .258 over the course of the season.

The Milwaukee pitching staff have surrendered 634 runs over the course of the season and come in with a team ERA of 3.58 (574 earned runs surrendered). They have conceded 168 dingers and they relinquish 3.96 runs per 9 innings (3rd in the league). The Brewers hold a team WHIP of 1.228 and are the owners of a FIP of 3.91 as a pitching staff on the campaign. Their K/BB ratio is 8.90 (1,432 strikeouts vs 534 walks). They have a ranking of 3rd in MLB as a staff in total hits relinquished with 1,237.

Milwaukee bullpen pitchers have an inherited score percentage of 31.7% of 218 inherited runners. Their relievers have taken the field 187 times in high leverage situations and on 145 occasions with base runners. With 177 save situations, the Brewers have recorded 107 holds and also 21 blown saves. They rank 5th in baseball with a save percentage of 68.2%, and they have sent 550 relievers onto the field on the campaign. Milwaukee has called on relief pitchers to enter the game in 66 save chances and they have earned 45 saves.

In their 12,978 innings played, the Brewers have accumulated a efficiency on defense of 70.9% (5th in pro baseball). The Milwaukee Brewers have gotten 122 double plays and have a fielding percentage of .987 (10th in the majors). The Brewers have racked up 1,297 assists, 76 errors and have accumulated 4,326 putouts this season.

So far in his MLB career, Misiorowski has surrendered 51 base knocks while totaling 87 strikeouts in 66 innings. Misiorowski (5-3 career record) has a 4.36 ERA and has surrendered 7.0 hits per 9 innings. He has allowed 32 ER's while earning a WHIP of 1.242 and having a FIP of 4.3. He has a K/BB ratio of 2.81 and he has gone up against 273 opposing hitters in his career.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Chicago (+162)

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