Chicago Cubs vs San Francisco Giants Prediction, 8/27/2025 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs San Francisco Giants

Date: Wednesday, August 27, 2025

Location: Oracle Park in San Francisco, CA

TV: NBC Bay Area

Odds/Point Spread: Chicago (-132) San Francisco (+110)

Oracle Park is the site where the San Francisco Giants (63-68) will take on the Chicago Cubs (76-55) on Wednesday. The odds on this game have Chicago at -132 and San Francisco is sitting at +110. The total is 8. The pitchers expected to start will be Colin Rea and Carson Whisenhunt.

Chicago has a slugging % of .428 and have struck out 1,014 times, while drawing a walk on 444 occasions. They have accounted for 632 RBI's in addition to 1,112 hits over the course of the season, and their batting average is sitting at .249. The Cubs have hit 216 doubles as a squad and have hit 178 baseballs out of the stadium. They have accounted for 648 runs and hold an OBP of .319. As a squad, the Chicago Cubs are notching 5.0 runs per outing, which ranks them 5th in the league.

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Their strikeout to walk ratio sits at 2.95 and the pitching staff has earned a collective WHIP of 1.19. Cubs pitchers have allowed 159 long balls and 522 total runs (5th in the league). Chicago has given up 1,050 base knocks (8.1 per 9 innings) and 486 earned runs. The Cubs are sitting with a team earned run average of 3.76 for the season (7th in the league), and they have struck out 1,002 hitters. They have walked 340 opposing batters and their FIP comes in at 4.15 as a squad on the campaign.

The Cubs relief pitchers have earned a save rate of 70.0% and have entered the game in 141 save situations. The bullpen pitchers have inherited 121 base runners on the season with 30.6% of them crossed home plate. Cubs pitchers have entered the contest with opponents on base 86 times in addition to having 127 appearances in high leverage situations. The Cubs have sent 425 relievers to the hill over the course of the season. The bullpen have accumulated 88 holds for the season (4th in the league). They have recorded 35 saves for the year and have blown 15 of 50 save opportunities.

The Boston Red Sox have amassed 3,491 putouts thus far, as well as 1,104 assists and 53 errors. Their fielding percentage is at .989 which has them sitting 4th in the majors, and have earned 101 double plays. The Cubs have turned 71.7% of baseballs in play into outs in their 10,473 innings on the diamond, ranking them 3rd in the majors.

Rea has taken the mound for 573 innings and has tallied 459 punch outs thus far in his career. Rea (36-25 win-loss mark in his career) holds a FIP of 4.38 and he has faced 2,438 hitters in the major leagues. His earned run average is 4.44 (283 earned runs allowed) and he has a WHIP of 1.280. He has given up 558 hits (8.8 hits per 9 innings) and has had 176 walks.

San Francisco has knocked in 128 long balls on the campaign as well as 504 runs batted in. They have notched 196 doubles, while taking a walk 444 times as well as earning 530 runs. The San Francisco Giants have accumulated an on-base percentage of .308 and a team batting average of .231 this season. The Giants have a SLG% of .376 and they score 4.05 runs per game (25th in MLB). They have struck out on 1,132 occasions (12th in the league) and have tallied 1,005 base knocks.

The San Francisco pitching staff have relinquished 540 runs this year while holding a team ERA of 3.74 (481 earned runs allowed). They have given up 114 homers and they yield 4.20 runs per 9 innings (8th in the league). The Giants hold a team WHIP of 1.286 and are the owners of a FIP of 3.71 as a unit this season. Their K/BB ratio comes in at 8.50 (1,095 strikeouts against 411 walks). They are currently ranked 18th in MLB as a pitching staff in total hits surrendered with 1,079.

San Francisco relievers hold an inherited score percentage of 34.7% out of 150 inherited runners. Their relief pitchers have taken the field 143 times in high leverage situations and on 94 occasions with base runners. Sitting with 118 save situations, the Giants have 70 holds and also 18 blown saves. They rank 18th in baseball holding a save rate of 62.5%, and they have sent 417 relief pitchers to the mound so far this season. San Francisco has had relievers step onto the hill in 48 save chances and they have come away with 30 saves.

The San Francisco Giants have turned 104 double plays and own a fielding percentage of .984 (25th in baseball). The Giants have accrued 1,229 assists, 78 errors and have earned 3,476 putouts on the season. In their 10,428 innings on the diamond, the Giants have a efficiency on defense of 68.7% (26th in baseball).

So far in his career, Whisenhunt has conceded 17 base hits and he has 13 punch outs in 18 innings pitched. Whisenhunt (1-1 record in his career) has a 4.97 ERA while surrendering 8.5 hits per 9 innings. He has conceded a total of 10 earned runs while earning a WHIP of 1.436 and a FIP of 4.9. His strikeout to walk ratio is 1.44 and he has faced 80 batters thus far in his career.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Chicago (-132)

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