Chicago Cubs vs St. Louis Cardinals Prediction, 6/26/2025 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs St. Louis Cardinals

Date: Thursday, June 26, 2025

Location: Busch Stadium in St. Louis, MO

TV: FanDuel Sports Network Midwest

Odds/Point Spread: Chicago (-122) St. Louis (+102)

The St. Louis Cardinals (44-36) welcome the Chicago Cubs (46-33) at Busch Stadium on Thursday. The moneyline on this matchup has Chicago at -122 and St. Louis is sitting at +102. The betting total is set at 8.5. The expected starting pitchers are Shota Imanaga and Andre Pallante.

The Cubs have accumulated 139 doubles as a squad and have knocked 113 baseballs out of the stadium. Chicago owns a slugging percentage of .442 and have struck out 616 times, while taking a walk on 271 occasions. As a unit, the Chicago Cubs are notching 5.4 runs per contest, which ranks them 2nd in the league. They have accounted for 411 runs batted in as well as 684 hits this season, and their average at the plate is at .254. They have racked up 419 runs scored and have an OBP of .324.

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The Cubs hold a team earned run average of 3.89 over the course of the season (15th in the league), and their staff has rung up 599 hitters. Cubs pitchers have conceded 92 long balls and 329 runs in total (16th in MLB). They have walked 220 players from the other team and their FIP sits at 4.13 as a unit this season. Chicago has given up 663 base knocks (8.5 per 9 innings) in addition to 302 earned runs. They have accumulated a K/BB ratio of 2.72 and the pitching staff has a collective WHIP of 1.26.

The Cubs have dispatched 261 relievers to the mound on the campaign. The relievers have inherited 81 base runners this year and 32.1% of those runners earned a run for their team. They have 18 saves for the season and have blown 9 of their 27 save chances. The Cubs relief pitchers have accumulated a save percentage of 66.7% and stepped onto the hill in 79 save situations. The relief pitchers have accumulated 49 holds for the year (11th in baseball). Cubs pitchers have come into the game with runners on base 60 times as well as having 90 appearances in high leverage situations.

The Cubs have converted 70.2% of balls hit into play into outs out of their 6,288 innings on the field, which ranks them 14th in baseball. The Boston Red Sox have amassed 2,096 putouts this season, in addition to 677 assists and 34 errors. Their fielding rate is holding at .988 which puts them in 8th in the majors, and they have turned 71 double plays.

Imanaga (18-5 career win-loss mark) sits with a FIP of 2.86 while facing 875 batters in the majors. He has allowed 184 base hits (7.6 hits per 9 innings) with 42 walks. His earned run average is 2.90 (70 earned runs allowed) and his WHIP is 1.040. Imanaga has taken the ball for 217 innings and is sitting with 208 punch outs during his career.

The St. Louis Cardinals are sitting with an on-base percentage of .327 and a team batting average of .255 for the season. They have been rung up on 616 occasions (22nd in baseball) and have totaled 687 hits. St. Louis has hit 78 HRs for the season to go along with 354 RBIs. The Cardinals have a slugging percentage of .396 and they earn 4.73 runs per contest (8th in baseball). They have put up 135 two-baggers, while taking a walk 254 times and putting up 374 runs.

The Cardinals hold a team WHIP of 1.257 and have a FIP of 3.64 as a pitching staff this season. Their strikeout to walk ratio sits at 7.30 (574 strikeouts against 213 walks). They come in at 21st in MLB as a staff in total hits surrendered with 671. They have allowed 64 long balls and they allow 4.27 runs per 9 innings (17th in the league). The St. Louis pitching staff have allowed 334 runs on the season while holding a team ERA of 3.90 (305 earned runs conceded).

St. Louis has had relievers step onto the hill in 31 save chances and they have tallied 19 saves. They are ranked 19th in MLB holding a save rate of 61.3%, and they have sent 239 relief pitchers onto the diamond this year. Their relievers have come in 89 times in high leverage situations and on 79 occasions with runners on. St. Louis bullpen pitchers hold an inherited score rate of 35.6% out of 101 inherited runners. Sitting with 80 save situations, the Cardinals have accrued 46 holds and 12 blown saves.

In their 6,333 innings played, the Cardinals have accumulated a efficiency on defense of 69.9% (16th in pro baseball). The St. Louis Cardinals have turned 59 double plays and hold a fielding percentage of .989 (5th in the majors). The Cardinals have recorded 767 assists, 32 errors and have 2,111 putouts over the course of the season.

So far in his career, Pallante has conceded 380 hits while he has accumulated 268 strikeouts in 379 frames. Pallante (23-17 career win-loss record) has earned a 3.94 ERA and has allowed 9.0 hits per nine innings. He has conceded 166 ER's while earning a WHIP of 1.384 and being the owner of a FIP of 3.9. His K/BB ratio is 1.85 and he has gone up against 1,620 batters so far in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take St. Louis (+102)

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