Chicago Cubs vs St. Louis Cardinals Prediction, 8/10/2025 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs St. Louis Cardinals

Date: Sunday, August 10, 2025

Location: Busch Stadium in St. Louis, MO

TV: FanDuel Sports Network Midwest

Odds/Point Spread: Chicago (-128) St. Louis (+106)

The St. Louis Cardinals (58-58) will try to beat the Chicago Cubs (66-48) at Busch Stadium on Sunday. The line on this matchup has Chicago at -128 and St. Louis is coming in at +106. The betting total is set at 8. The starting pitchers are Shota Imanaga and Sonny Gray.

The Cubs have hit 194 doubles as a squad and have hit 164 baseballs out of the park. Chicago is slugging .439 and have been called out on strikes 889 times, while being walked on 385 occasions. As a squad, the Chicago Cubs are compiling 5.2 runs per outing, which is 1st in MLB. They have earned 573 runs batted in and 992 hits on the season, while their batting average is sitting at .253. They have 588 runs scored while holding a team on-base percentage of .323.

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The Cubs hold a team earned run average of 3.89 this season (15th in the league), and their staff has rung up 862 hitters. Cubs pitchers have allowed 144 home runs and also 473 runs (10th in MLB). They have walked 296 opposing batters and their FIP is 4.24 as a squad for the season. Chicago has relinquished 937 hits (8.3 per 9 innings) as well as 439 earned runs. Their strikeout to walk ratio sits at 2.91 and the pitching staff holds a collective WHIP of 1.22.

Cubs pitchers have entered the contest with players on base 79 times in addition to having 110 appearances in high leverage situations. The relievers have a total of 75 holds so far this season (7th in the league). The Cubs relievers have earned a save rate of 66.7% and have entered the game in 117 save situations. They have recorded 26 saves for the season and have blown 13 of their 39 chances to save the game. The relief pitchers have inherited 110 base runners on the season with 30.9% of them crossed the plate. The Cubs have sent 379 relief pitchers to the mound this season.

The Boston Red Sox have accumulated 3,044 putouts for the season, as well as 957 assists and 48 errors. Their fielding percentage is holding at .988 which ranks 6th in professional baseball, and have accumulated 89 double plays. The Cubs have converted 71.4% of balls hit into play into outs out of 9,132 innings on the diamond, which has them ranked 3rd in professional baseball.

Imanaga has taken the mound for 262 innings and has earned 244 K's in his career. Imanaga (23-7 win-loss record in his career) is the owner of a FIP of 2.94 while going up against 1,047 opposing hitters in the major leagues. His earned run average is 2.99 (87 earned runs allowed) and he has a WHIP of 1.014. He has given up 221 base hits (7.6 hits per nine innings) and has had 45 walks.

The Cardinals have a team slugging % of .388 and they are earning 4.39 runs per contest (14th in the league). They have recorded 200 doubles, while walking 359 times as well as putting up 509 runs. St. Louis has recorded 111 home runs this year as well as 485 RBIs. They have struck out on 901 occasions (23rd in baseball) and have earned a total of 974 hits. The St. Louis Cardinals have accounted for an OBP of .319 and a batting average of .249 on the season.

The Cardinals hold a team WHIP of 1.289 with a FIP of 3.89 as a unit for the year. Their K/BB ratio comes in at 7.40 (839 strikeouts against 304 walks). They come in at 26th in MLB as a pitching staff in total hits allowed with 1,015. They have conceded 113 homers and they allow 4.62 runs per 9 innings (23rd in MLB). The St. Louis pitching staff have given up 525 runs over the course of the season while having a team ERA of 4.22 (480 earned runs yielded).

St. Louis relievers hold an inherited score percentage of 33.1% out of 151 inherited base runners. Their bullpen pitchers have stepped onto the mound 111 times in high leverage situations in addition to 110 occasions with runners on. With 111 save situations, the Cardinals have accrued 64 holds and 15 blown saves. They sit at 10th in the league with a save percentage of 65.9%, and they have sent 345 bullpen pitchers to the mound this season. St. Louis has had bullpen pitchers step onto the mound in 44 save opportunities and they have come away with 29 saves.

The St. Louis Cardinals have turned 88 double plays and own a fielding percentage of .988 (8th in pro baseball). The Cardinals have accrued 1,116 assists, 51 errors and have earned 3,071 putouts over the course of the season. In their 9,213 innings on the field, the Cardinals hold a defensive efficiency of 69.3% (20th in professional baseball).

During his MLB career, Gray has allowed 1,619 base knocks while he has totaled 1,865 K's in 1,865 frames. Gray (121-99 career mark) is the owner of a 3.56 earned run average while allowing 7.8 hits per nine innings. He has conceded 737 ER's while earning a WHIP of 1.192 and a FIP of 3.5. He has a strikeout to walk ratio of 3.09 and he has faced 7,725 hitters so far in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Chicago (-128)

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