Chicago White Sox vs Chicago Cubs Prediction, 5/17/2025 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Chicago Cubs

Date: Saturday, May 17, 2025

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: Chicago (+110) Chicago (-132)

The Chicago Cubs (25-19) welcome the Chicago White Sox (14-29) at Wrigley Field on Saturday. The odds on this game have Chicago at +110 and Chicago is opening at -132. The total has been set at 8. The pitchers taking the mound will be Sean Burke and Matthew Boyd.

As a team, the Chicago White Sox are scoring 3.4 runs per game, which has them at 27th in MLB. They have earned 148 runs while having a team on-base percentage of .292. The White Sox have accumulated 57 two-baggers as a unit and have smacked 32 baseballs out of the stadium. They have 143 runs batted in as well as 301 hits this season, while their average at the plate is .216. Chicago is slugging .328 and have struck out 369 times, while taking a walk on 142 occasions.

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They have accumulated a K/BB ratio of 1.94 and the pitching staff has a collective WHIP of 1.36. White Sox pitchers have given up 45 home runs in addition to 177 runs in total (12th in the league). Chicago has allowed 345 base hits (8.4 per 9 innings) and 163 earned runs. The White Sox hold a team ERA of 3.96 so far this year (15th in MLB), and the staff has rung up 310 batters. Their pitching staff has walked 160 opposing batters and their FIP is 4.52 as a squad on the season.

White Sox relief pitchers have gone to the mound with players on base 42 times in addition to having 38 appearances in high leverage situations. The relief pitchers have 20 holds this year (25th in MLB). The White Sox relief pitchers have a save percentage of 30.0% and stepped onto the hill in 30 save situations. They have earned 3 saves over the course of the season and have blown 7 of their 10 chances to get a save. The relievers have inherited 58 base runners so far this season and 34.5% of those runners earned a run for their team. The White Sox have sent 142 relievers to the mound for the season.

The Chicago Cubs have earned a total of 1,111 putouts for the season, in addition to 353 assists and 29 errors. Their fielding rate sits at .981 which has them sitting 27th in baseball, and they have turned 36 double plays. The White Sox have transformed 70.1% of balls in play into outs out of their 3,333 innings on the diamond, which has them sitting at 14th in MLB.

Burke has thrown 62 innings and has 51 strikeouts during his MLB career. Burke (4-4 record in his career) sits with a FIP of 3.28 while facing 267 opposing batters in the majors. His earned run average is 3.33 (23 earned runs allowed) and he has a career WHIP of 1.288. He has given up 51 base knocks (7.4 hits per nine innings) and has 29 walks.

The Cubs have a team slugging % of .436 and they are earning 5.55 runs per game (2nd in MLB). They have recorded 75 doubles, while getting a free base 168 times as well as recording 244 runs. Chicago has hit 63 HRs so far this season and 240 runs batted in. They have struck out on 353 occasions (17th in MLB) and have notched a total of 380 hits. The Chicago Cubs have recorded a team OBP of .327 and a batting average of .250 so far this season.

The Chicago pitching staff have relinquished 192 runs on the year and come in with a team ERA of 4.02 (176 earned runs relinquished). They have given up 52 home runs and they surrender 4.39 runs per 9 innings (18th in baseball). The Cubs have a team WHIP of 1.302 and have a FIP of 4.21 as a pitching staff this year. Their strikeout to walk ratio is 8.10 (355 strikeouts against 140 walks). They come in at 21st in baseball as a staff in total hits surrendered with 373.

Sitting with 44 save situations, the Cubs have compiled 26 holds in addition to 7 blown saves. Chicago has called on bullpen pitchers to take the mound in 17 save chances and they have walked away with 10 saves. Their relief pitchers have stepped onto the hill 47 times in high leverage situations in addition to 35 occasions with runners on. Chicago bullpen pitchers have an inherited score percentage of 38.0% of 50 inherited runners. They are currently ranked 23rd in MLB with a save rate of 58.8%, and they have sent 152 relievers onto the field on the year.

Out of their 3,546 innings on the field, the Cubs have accumulated a defensive efficiency of 69.8% (16th in professional baseball). The Chicago Cubs have gotten 36 double plays and own a fielding percentage of .985 (20th in pro baseball). The Cubs have recorded 355 assists, 24 errors and have notched a total of 1,182 putouts for the season.

During his pro baseball career, Boyd has allowed 945 hits while totaling 936 K's in 953 innings pitched. He has surrendered a total of 503 ER's while holding a WHIP of 1.313 and having a FIP of 4.7. He has a K/BB ratio of 3.05 and he has gone up against 4,088 batters during his MLB career. Boyd (49-71 career mark) has a 4.75 ERA while conceding 8.9 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Chicago (+110)

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