Chicago White Sox vs Chicago Cubs Prediction, 5/18/2025 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Chicago Cubs

Date: Sunday, May 18, 2025

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: Chicago (+126) Chicago (-152)

The Chicago Cubs (25-19) will take on the Chicago White Sox (14-30) at Wrigley Field on Sunday. The odds on this game have Chicago at +126 and Chicago opens at -152. The over/under has been set at 9. The pitchers taking the mound will be Jonathan Cannon and Colin Rea.

The White Sox have tallied 58 two-baggers as a squad and have knocked 32 balls out of the park. Chicago is slugging .324 and have been rung up 375 times, while being walked on 143 occasions. As a unit, the Chicago White Sox are putting up 3.4 runs/g, which ranks them 28th in the league. They have recorded 144 RBI's in addition to 305 hits for the year, and their team batting average is sitting at .214. They have 149 runs scored while holding a team on-base percentage of .289.

Get all of our MLB Expert Picks

The White Sox hold a team earned run average of 4.04 for the year (20th in baseball), and the staff has rung up 315 batters. White Sox pitchers have given up 48 long balls in addition to 184 runs in total (13th in baseball). Their pitching staff has walked 163 opposing hitters and their FIP comes in at 4.58 as a squad over the course of the season. Chicago has yielded 357 hits (8.5 per 9 innings) and also 170 earned runs. They have earned a K/BB ratio of 1.93 and their pitching staff holds a collective WHIP of 1.38.

The White Sox have dispatched 144 relievers to the hill over the course of the season. The bullpen pitchers have inherited 58 runners for the season with 34.5% of them ended up crossing the plate. They have recorded 3 saves this year and have blown 7 of their 10 save chances. The White Sox relief pitchers have a save rate of 30.0% and have entered the game in 30 save situations. The relievers have 20 holds over the course of the season (25th in MLB). White Sox relief pitchers have entered the game with players on base 42 times as well as having 38 appearances in high leverage situations.

The Chicago Cubs have earned a total of 1,135 putouts at this point in the season, as well as 361 assists and 30 errors. Their fielding percentage is currently at .980 which has them sitting 28th in baseball, and have 38 double plays. The White Sox have converted 69.9% of balls in play into outs out of their 3,405 innings, which has them sitting at 16th in the majors.

Cannon (7-14 mark in his career) is the owner of a FIP of 4.18 and he has gone up against 739 opposing batters in the major leagues. He has surrendered 176 base hits (9.1 hits per nine innings) and has had 57 free passes. His ERA is 4.24 (82 ER's allowed) and his career WHIP is 1.338. Cannon has taken the mound for 174 innings and has earned 130 punch outs so far in his MLB career.

The Chicago Cubs have accounted for an OBP of .327 as well as a batting average of .250 so far this year. They have been rung up on 353 occasions (17th in baseball) and have notched a total of 380 hits. Chicago has accumulated 63 home runs this season as well as 240 runs batted in. The Cubs hold a team slugging percentage of .436 and they tally 5.55 runs per contest (3rd in the league). They have 75 two-baggers, while walking 168 times and scoring 244 runs.

The Chicago pitching staff have allowed 192 runs so far this season while holding a team ERA of 4.02 (176 earned runs conceded). They have conceded 52 long balls and they concede 4.39 runs per 9 innings (18th in the league). The Cubs hold a team WHIP of 1.302 and have a FIP of 4.19 as a squad so far this year. Their strikeout to walk ratio is 8.10 (355 strikeouts vs 140 free passes). They are sitting at 21st in the league as a pitching staff in total hits given up with 373.

With 44 save situations, the Cubs have accrued 26 holds and 7 blown saves. Chicago has had relievers enter the contest in 17 save chances and they have converted 10 saves. Their relief pitchers have stepped onto the mound 47 times in high leverage situations and also on 35 occasions with runners on base. Chicago relievers have an inherited score percentage of 38.0% out of 50 inherited base runners. They are currently ranked 23rd in the league with a save percentage of 58.8%, and they have sent 152 bullpen pitchers to the hill for the season.

Out of their 3,546 innings played, the Cubs have a defensive efficiency of 69.8% (17th in MLB). The Chicago Cubs have gotten 36 double plays and have a fielding percentage of .985 (20th in the majors). The Cubs have accrued 355 assists, 24 errors and have 1,182 putouts so far this season.

Rea (29-20 win-loss record in his career) has a 4.42 earned run average while surrendering 8.7 hits per 9 innings. His K/BB ratio is 2.69 and he has faced 2,052 batters during his MLB career. He has given up a total of 237 earned runs while earning a WHIP of 1.273 and being the owner of a FIP of 4.4. During his MLB career, Rea has given up 467 base hits while accumulating 395 punch outs in 482 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Chicago (+126)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here