Chicago White Sox vs Cleveland Guardians Prediction, 9/12/2025 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Cleveland Guardians

Date: Friday, September 12, 2025

Location: Progressive Field in Cleveland, OH

TV: CLEGuardians.TV

Odds/Point Spread: Chicago (+126) Cleveland (-152)

The Chicago White Sox (56-90) are headed to Progressive Field on Friday where they will try to defeat the Cleveland Guardians (74-71). The moneyline on this contest has Chicago at +126 while Cleveland is coming in at -152. The betting total comes in at 8. The pitchers taking the mound will be Martin Perez and Tanner Bibee.

Chicago has a slugging rate of .379 and have struck out 1,218 times, while being walked on 457 occasions. They have accumulated 572 runs batted in and 1,146 hits this season, while their average at the plate comes in at .236. The White Sox have hit 227 doubles as a unit and have hit 150 baseballs out of the park. They have earned 592 runs while having a team OBP of .305. As a unit, the Chicago White Sox are putting up 4.1 runs/g, which has them sitting at 26th in MLB.

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They have a strikeout to walk ratio of 2.11 and the pitching staff has recorded a WHIP of 1.37. White Sox pitchers have allowed 166 home runs and 672 total runs (21st in baseball). Chicago has relinquished 1,204 hits (8.5 per 9 innings) and also 603 earned runs. The White Sox have an ERA of 4.25 this year (20th in the league), and the staff has struck out 1,141 batters. Their pitching staff has walked 542 opposing hitters and their FIP comes in at 4.48 as a unit over the course of the season.

White Sox bullpen pitchers have stepped onto the hill with players on base 147 times in addition to having 140 appearances in high leverage situations. The bullpen have a total of 63 holds so far this season (27th in the league). The White Sox relievers have recorded a save percentage of 52.3% and stepped onto the hill in 109 save situations. They have earned 23 saves so far this year and have blown 21 of their 44 chances to save the game. The relief pitchers have inherited 214 base runners for the year and 32.2% of those runners ended up scoring. The White Sox have dispatched 475 relief pitchers to the mound on the campaign.

The Chicago Cubs have accumulated 3,835 putouts thus far, as well as 1,160 assists and 95 errors. Their fielding percentage is currently at .981 which puts them in 28th in MLB, and they have turned 117 double plays. The White Sox have turned 69.7% of baseballs in play into outs out of their 11,505 innings on the field, which has them sitting 16th in the majors.

Perez (91-91 career win-loss record) sits with a FIP of 4.34 while facing 7,028 batters during his time in the majors. He has surrendered 1,741 base hits (9.7 hits per 9 innings) and has 586 walks. His earned run average is 4.41 (794 ER's allowed) and his WHIP is 1.436. Perez has thrown 1,620 innings and has earned 1,148 strikeouts so far in his MLB career.

The Guardians have a team slugging percentage of .370 and they have an average of 3.91 runs per game (27th in baseball). They have hit 211 two-baggers, while walking 444 times and scoring 567 runs. Cleveland has compiled 148 long balls on the campaign to go along with 547 RBIs. They have struck out on 1,204 occasions (17th in the league) and have notched a total of 1,072 base hits. The Cleveland Guardians have an OBP of .297 and a batting average of .225 so far this season.

The Guardians are sitting with a team WHIP of 1.303 in addition to having a FIP of 4.10 as a team for the season. They have earned a strikeout to walk ratio of 8.40 (1,195 strikeouts against 491 free passes). They come in at 14th in MLB as a staff in total hits conceded with 1,187. They have given up 155 dingers and they concede 4.23 runs per 9 innings (11th in MLB). The Cleveland pitching staff have surrendered 606 runs so far this season while having an ERA of 3.87 (554 earned runs conceded).

Cleveland has called on bullpen pitchers to step onto the mound in 61 save opportunities and they have come away with 42 saves. They are ranked 5th in the league with a save percentage of 68.9%, and they have dispatched 475 relief pitchers onto the diamond so far this year. Their relievers have stepped onto the mound 167 times in high leverage situations and on 134 occasions with base runners. Cleveland relievers hold an inherited score rate of 33.7% out of 187 inherited runners. Sitting with 159 save situations, the Guardians have 95 holds and also 19 blown saves.

The Cleveland Guardians have gotten 112 double plays and have a fielding rate of .983 (27th in the majors). The Guardians have 1,198 assists, 89 errors and have a tally of 3,864 putouts for the year. In 11,592 innings on the field, the Guardians are sitting with a efficiency on defense of 69.5% (19th in the majors).

During his MLB career, Bibee has given up 431 hits while he has accumulated 467 punch outs in 476 innings. Bibee (31-23 career win-loss mark) has earned a 3.74 earned run average while allowing 8.1 hits per 9 innings. He has given up a total of 198 ER's while holding a WHIP of 1.197 and having a FIP of 3.7. He has a K/BB ratio of 3.36 and he has faced 1,979 opposing hitters in his career.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Chicago (+126)

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