Chicago White Sox vs Cleveland Guardians Prediction, 9/13/2025 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Cleveland Guardians

Date: Saturday, September 13, 2025

Location: Progressive Field in Cleveland, OH

TV: CLEGuardians.TV

Odds/Point Spread: Chicago (+126) Cleveland (-152)

The Chicago White Sox (56-90) are headed to Progressive Field on Saturday where they will attempt to defeat the Cleveland Guardians (74-71). The odds on this game have Chicago at +126 and Cleveland is opening at -152. The over/under is set at 9. The pitchers taking the mound will be Davis Martin and Parker Messick.

Chicago is slugging .379 and have been called out on strikes 1,218 times, while taking a walk on 457 occasions. They have accounted for 572 RBI's and 1,146 hits on the year, and their batting average is at .236. The White Sox have earned 227 doubles as a unit and have knocked 150 baseballs out of the stadium. They have racked up 592 runs while holding a team OBP of .305. As a team, the Chicago White Sox are compiling 4.1 runs per contest, which ranks them 26th in baseball.

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The White Sox are sitting with a team earned run average of 4.25 on the year (20th in baseball), and their staff has struck out 1,141 hitters. White Sox pitchers have yielded 166 home runs and also 672 runs in total (21st in the league). Their pitching staff has walked 542 batters and their FIP comes in at 4.48 as a team so far this season. Chicago has allowed 1,204 base hits (8.5 per 9 innings) and also 603 earned runs. They have a K/BB ratio of 2.11 and the pitching staff holds a collective WHIP of 1.37.

White Sox relief pitchers have entered the contest with players on base 147 times and also have had 140 appearances in high leverage situations. The relievers have accumulated 63 holds this year (27th in baseball). The White Sox bullpen have recorded a save percentage of 52.3% and have come into the game in 109 save situations. They have recorded 23 saves this year and have missed out on 21 out of their 44 save opportunities. The relievers have inherited 214 base runners this year and 32.2% of those players ended up crossing the plate. The White Sox have dispatched 475 relief pitchers to the mound for the year.

The White Sox have converted 69.7% of balls hit into play into outs out of 11,505 innings, ranking them 16th in MLB. The Chicago Cubs have earned a total of 3,835 putouts so far this season, as well as 1,160 assists and 95 errors. Their fielding percentage is holding at .981 which puts them in 28th in professional baseball, and have accumulated 117 double plays.

Martin has taken the hill for 240 frames and has accounted for 187 strikeouts during his MLB career. Martin (9-20 win-loss record in his career) sits with a FIP of 4.24 and he has faced 1,023 hitters in the major leagues. His earned run average is 4.31 (115 ER's allowed) and his career WHIP is 1.324. He has surrendered 232 base knocks (8.7 hits per 9 innings) and has 86 walks.

The Guardians hold a team slugging % of .370 and they are earning 3.91 runs per game (27th in the league). They have tallied 211 two-baggers, while getting a free base 444 times and notching 567 runs. Cleveland has compiled 148 long balls so far this season as well as 547 runs batted in. They have been rung up on 1,204 occasions (17th in the league) and have earned 1,072 base hits. The Cleveland Guardians hold a team OBP of .297 and a team batting average of .225 over the course of the season.

The Guardians have a team WHIP of 1.303 and have a FIP of 4.10 as a team on the season. They rank 14th in MLB as a staff in total hits given up with 1,187. The Cleveland pitching staff have surrendered 606 runs for the season and come in with a team ERA of 3.87 (554 earned runs yielded). Their strikeout to walk ratio sits at 8.40 (1,195 strikeouts against 491 bases on balls). They have surrendered 155 long balls and they allow 4.23 runs per 9 innings (11th in baseball).

Cleveland has called on bullpen pitchers to take the mound in 61 save chances and they have come away with 42 saves. They are currently ranked 5th in the league holding a save percentage of 68.9%, and they have dispatched 475 bullpen pitchers to the hill so far this year. Their relievers have taken the field 167 times in high leverage situations and also on 134 occasions with base runners. Cleveland relief pitchers have an inherited score percentage of 33.7% of 187 inherited runners. With 159 save situations, the Guardians have earned 95 holds in addition to 19 blown saves.

In their 11,592 innings on the diamond, the Guardians have accumulated a defensive efficiency of 69.5% (19th in the majors). The Cleveland Guardians have gotten 112 double plays and have a fielding percentage of .983 (27th in pro baseball). The Guardians have accrued 1,198 assists, 89 errors and have notched a total of 3,864 putouts for the season.

In his MLB career, Messick has conceded 28 base knocks while he has earned 18 K's in 23 innings pitched. Messick (2-0 career win-loss mark) is the owner of a 1.95 ERA and has surrendered 10.9 hits per nine innings. He has conceded 5 ER's while earning a WHIP of 1.342 and having a FIP of 1.9. His K/BB ratio is 6.00 and he has faced 96 opposing batters in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Chicago (+126)

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