Chicago White Sox vs Minnesota Twins Prediction, 9/3/2025 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Minnesota Twins

Date: Wednesday, September 3, 2025

Location: Target Field in Minneapolis, MN

TV: Twins.TV

Odds/Point Spread: Chicago (+125) Minnesota (-150)

Target Field is where the Minnesota Twins (62-75) will take on the Chicago White Sox (50-88) on Wednesday. The odds on this game have the White Sox at +125 and the Twins are at -150. The total has been set at 8. The expected starting pitchers will be Shane Smith and Zebby Matthews.

The White Sox have earned 210 doubles as a unit and have hit 138 balls out of the park. Chicago is slugging .374 and have struck out 1,140 times, while being walked on 430 occasions. As a unit, the Chicago White Sox are earning 3.9 runs per contest, which is 26th in the league. They have recorded 523 runs batted in and 1,072 hits for the season, and their average at the plate comes in at .234. They have notched a total of 542 runs and have an on-base percentage of .302.

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They have a strikeout to walk ratio of 2.08 and their pitching staff has earned a collective WHIP of 1.37. White Sox pitchers have allowed 155 home runs and 633 total runs (21st in baseball). Chicago has allowed 1,139 base hits (8.5 per 9 innings) and also 567 earned runs. The White Sox have a team ERA of 4.23 on the year (19th in the league), and their staff has rung up 1,065 hitters. Their pitching staff has walked 512 opposing hitters and their FIP sits at 4.48 as a unit over the course of the season.

White Sox pitchers have entered the game with runners on base 136 times and also have had 125 appearances in high leverage situations. The bullpen have recorded 56 holds for the year (28th in the league). The White Sox relievers have recorded a save rate of 47.5% and have entered the game in 96 save situations. They have earned 19 saves this season and have blown 21 out of their 40 save opportunities. The relief pitchers have inherited 199 runners over the course of the season and 32.7% of those runners ended up scoring. The White Sox have sent 443 relief pitchers to the hill this year.

The White Sox have transformed 69.7% of balls in play into outs in their 10,866 innings on the field, which has them ranked 17th in baseball. The Chicago Cubs have notched a total of 3,622 putouts for the season, in addition to 1,108 assists and 90 errors. Their fielding rate is at .981 which has them ranked 28th in pro baseball, and have a total of 111 double plays.

Smith (4-7 career win-loss mark) has a FIP of 3.76 while going up against 510 batters during his time in the major leagues. He has surrendered 95 hits (7.1 hits per 9 innings) and has had 50 walks. His ERA is 3.82 (51 earned runs allowed) and he has a WHIP of 1.207. Smith has taken the ball for 120 innings and has accumulated 112 K's thus far in his career.

The Minnesota Twins have tallied a team OBP of .311 and a batting average of .238 this year. They have been rung up on 1,135 occasions (16th in the league) and have notched a total of 1,091 hits. Minnesota has accumulated 163 HRs this year and 550 RBIs. The Twins have a team slugging % of .397 and they have an average of 4.22 runs per game (23rd in baseball). They have notched 210 two-baggers, while taking a walk 420 times and scoring 578 runs.

The Twins have a team WHIP of 1.316 and have a FIP of 4.10 as a squad on the campaign. Their K/BB ratio sits at 8.50 (1,142 strikeouts against 383 free passes). They come in at 24th in MLB as a staff in total hits surrendered with 1,204. They have allowed 164 dingers and they give up 4.79 runs per 9 innings (23rd in the league). The Minnesota pitching staff have allowed 642 runs on the season while holding an ERA of 4.47 (599 earned runs yielded).

Minnesota relievers have an inherited score rate of 37.0% out of their 146 inherited base runners. Their bullpen pitchers have taken the field 157 times in high leverage situations in addition to 102 occasions with base runners. With 131 save situations, the Twins have 82 holds and also 21 blown saves. They rank 27th in baseball holding a save percentage of 55.3%, and they have sent 466 relief pitchers to the hill so far this season. Minnesota has called on bullpen pitchers to enter the contest in 47 save chances and they have earned 26 saves.

The Minnesota Twins have turned 85 double plays and own a fielding percentage of .986 (17th in pro baseball). The Twins have racked up 1,025 assists, 66 errors and have 3,618 putouts during this campaign. In 10,854 innings played, the Twins hold a efficiency on defense of 68.4% (27th in pro baseball).

So far in his MLB career, Matthews has surrendered 120 base hits while tallying 113 K's in 95 frames. Matthews (5-8 career mark) holds a 5.75 ERA while conceding 11.3 hits per 9 innings. He has given up a total of 61 ER's while earning a WHIP of 1.562 and being the owner of a FIP of 5.7. His strikeout to walk ratio is 3.90 and he has gone up against 436 batters during his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Chicago (+125)

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