Chicago White Sox vs New York Yankees Prediction, 9/24/2025 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs New York Yankees

Date: Wednesday, September 24, 2025

Location: Yankee Stadium in Bronx, NY

TV: YES

Odds/Point Spread: Chicago (+125) New York (-145)

The New York Yankees (88-68) welcome the Chicago White Sox (58-98) at Yankee Stadium on Wednesday. The moneyline on this game has the White Sox at +125 while the Yankees are coming in at -145. The betting total comes in at 8.5. The expected starting pitchers will be Tyler Alexander and Max Fried.

As a team, the Chicago White Sox are notching 4.0 runs per outing, which is 26th in MLB. They have earned 618 runs scored while holding a team OBP of .302. The White Sox have accumulated 234 two-baggers as a squad and have hit 156 baseballs out of the stadium. They have amassed 597 runs batted in and 1,201 hits on the campaign, while their team batting average is at .232. Chicago has a slugging percentage of .372 and have been called out on strikes 1,313 times, while being walked on 486 occasions.

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The White Sox have a team earned run average of 4.23 over the course of the season (20th in the league), and the staff has rung up 1,221 batters. White Sox pitchers have allowed 177 home runs and also 711 total runs (20th in MLB). They have walked 571 opposing batters and their FIP is 4.45 as a unit over the course of the season. Chicago has conceded 1,284 base knocks (8.5 per 9 innings) and also 641 earned runs. They have earned a strikeout to walk ratio of 2.14 and their pitching staff has earned a collective WHIP of 1.36.

The White Sox have dispatched 509 relief pitchers to the mound so far this season. The bullpen pitchers have inherited 228 runners on the year and 31.6% of them earned a run for their team. They have compiled 24 saves for the year and have missed out on 21 of 45 chances to get a save. The White Sox relief pitchers have earned a save percentage of 53.3% and stepped onto the hill in 113 save situations. The relief pitchers have earned 66 holds for the season (28th in the league). White Sox bullpen pitchers have entered the contest with runners on base 157 times in addition to having 144 appearances in high leverage situations.

The White Sox have converted 69.7% of balls hit into play into outs in their 12,288 innings on the diamond, which has them sitting at 19th in pro baseball. The Chicago Cubs have amassed 4,096 putouts this season, as well as 1,230 assists and 98 errors. Their fielding percentage is holding steady at .982 which puts them in 28th in the majors, and they have turned 126 double plays.

Alexander has thrown 543 frames and has earned 442 punch outs so far in his pro baseball career. His ERA is 4.66 (281 ER's allowed) and he has a career WHIP of 1.303. He has surrendered 580 hits (9.6 hits per 9 innings) and has 128 walks. Alexander (22-42 career record) sits with a FIP of 4.59 while he has gone up against 2,313 batters during his time in the major leagues.

New York has recorded 263 home runs so far this season to go along with 788 runs batted in. They have tallied 249 doubles, while taking a walk 609 times as well as scoring 816 runs. The New York Yankees have accounted for an on-base percentage of .330 and a batting average of .250 so far this year. The Yankees have a team slugging % of .454 and they are recording 5.23 runs per game (1st in baseball). They have struck out on 1,408 instances (3rd in MLB) and have notched a total of 1,320 base knocks.

The New York pitching staff have yielded 672 runs on the season while having a team ERA of 3.98 (612 earned runs conceded). They have conceded 168 home runs and they allow 4.37 runs per 9 innings (17th in baseball). The Yankees hold a team WHIP of 1.261 in addition to having a FIP of 4.00 as a unit for the year. Their K/BB ratio comes in at 9.00 (1,388 strikeouts vs 540 walks). They are sitting at 5th in baseball as a staff in total hits relinquished with 1,207.

New York has had relievers take the mound in 62 save chances and they have converted 41 saves. They are ranked 7th in the league with a save percentage of 66.1%, and they have dispatched 515 relievers onto the field on the year. Their relievers have stepped onto the mound 160 times in high leverage situations and on 165 occasions with runners on base. New York relievers have an inherited score percentage of 27.9% of 251 inherited runners. With 159 save situations, the Yankees have 95 holds and also 21 blown saves.

In their 12,471 innings played, the Yankees have accumulated a defensive efficiency of 70.5% (10th in pro baseball). The New York Yankees have turned 104 double plays and own a fielding percentage of .984 (23rd in professional baseball). The Yankees have recorded 1,347 assists, 90 errors and have earned 4,157 putouts so far this season.

In his career, Fried has surrendered 943 base hits while tallying 1,045 strikeouts in 1,072 innings. He has allowed 363 earned runs while holding a WHIP of 1.155 and a FIP of 3.0. He has a K/BB ratio of 3.54 and he has faced 4,388 opposing hitters in his career. Fried (91-41 win-loss mark in his career) has a 3.05 ERA while giving up 7.9 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Chicago (+125)

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