Chicago White Sox vs New York Yankees Prediction, 9/25/2025 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs New York Yankees

Date: Thursday, September 25, 2025

Location: Yankee Stadium in Bronx, NY

TV: YES

Odds/Point Spread: Chicago (+172) New York (-210)

The Chicago White Sox (58-99) are headed to Yankee Stadium on Thursday where they will attempt to defeat the New York Yankees (89-68). The moneyline on this game has Chicago at +172 and New York is at -210. The betting total is set at 8. The pitchers taking the mound will be Davis Martin and Carlos Rodon.

As a squad, the Chicago White Sox are putting up 4.0 runs per contest, which puts them at 28th in the league. They have accumulated 620 runs and have an on-base percentage of .302. The White Sox have recorded 235 two-baggers as a squad and have knocked 157 baseballs out of the park. They have compiled 599 RBI's as well as 1,208 base knocks for the season, and their team batting average sits at .232. Chicago has a slugging rate of .372 and have struck out 1,318 times, while drawing a walk on 488 occasions.

Get all of our Free MLB Picks

Their K/BB ratio is 2.13 and their pitching staff has a team WHIP of 1.36. White Sox pitchers have allowed 177 long balls and 714 runs (20th in baseball). Chicago has relinquished 1,295 base hits (8.5 per 9 innings) and 644 earned runs. The White Sox have an ERA of 4.22 for the season (19th in MLB), and the staff has struck out 1,233 hitters. Their pitching staff has walked 578 opposing batters and their FIP is 4.44 as a unit this season.

The White Sox have sent 514 relief pitchers to the hill this year. The relievers have inherited 230 runners on the season with 31.7% of them ended up crossing the plate. They have earned 24 saves this season and have not converted 22 of their 46 chances to save the game. The White Sox relief pitchers have compiled a save rate of 52.2% and have come into the game in 117 save situations. The bullpen have notched 69 holds over the course of the season (27th in the league). White Sox bullpen pitchers have entered the contest with players on base 158 times as well as having 149 appearances in high leverage situations.

The White Sox have converted 69.6% of baseballs in play into outs in their 12,366 innings, ranking them 20th in the majors. The Chicago Cubs have accounted for 4,122 putouts over the course of the season, as well as 1,240 assists and 98 errors. Their fielding rate is at .982 which is 28th in professional baseball, and have earned 128 double plays.

Martin has pitched in 251 frames and has totaled 194 punch outs in his MLB career. Martin (10-21 win-loss mark in his career) sits with a FIP of 4.23 while going up against 1,069 hitters in the majors. His ERA is 4.30 (120 ER's allowed) and his WHIP is 1.318. He has surrendered 243 base hits (8.7 hits per 9 innings) with 88 free passes.

The New York Yankees have accumulated an on-base percentage of .331 in addition to a team batting average of .250 this year. They have been rung up on 1,420 occasions (3rd in the league) and have earned a total of 1,331 base hits. New York has accumulated 263 home runs this season and 790 runs batted in. The Yankees have a team slugging % of .453 and they tally 5.22 runs per outing (1st in the league). They have hit 250 two-baggers, while walking 616 times as well as earning 819 runs.

The New York pitching staff have yielded 674 runs so far this season and come in with a team ERA of 3.96 (614 earned runs surrendered). They have conceded 169 homers and they allow 4.35 runs per 9 innings (16th in baseball). The Yankees hold a team WHIP of 1.260 and have a FIP of 4.00 as a unit on the season. They currently have a K/BB ratio of 9.00 (1,393 strikeouts vs 542 free passes). They have a ranking of 4th in baseball as a pitching staff in total hits given up with 1,214.

New York relief pitchers have an inherited score percentage of 27.8% out of 252 inherited base runners. Their relief pitchers have come in 160 times in high leverage situations and on 166 occasions with runners on base. With 159 save situations, the Yankees have tallied 95 holds and also 21 blown saves. They are currently ranked 7th in baseball holding a save percentage of 66.1%, and they have sent 518 relievers onto the field on the campaign. New York has had bullpen pitchers step onto the mound in 62 save opportunities and they have tallied 41 saves.

Out of their 12,552 innings on the diamond, the Yankees have accumulated a efficiency on defense of 70.5% (10th in MLB). The New York Yankees have gotten 104 double plays and own a fielding percentage of .984 (25th in the majors). The Yankees have racked up 1,355 assists, 91 errors and have accounted for 4,184 putouts for the season.

During his career, Rodon has allowed 1,081 hits while earning 1,404 strikeouts in 1,275 frames. He has given up a total of 529 ER's while holding a WHIP of 1.221 and being the owner of a FIP of 3.7. His K/BB ratio is 2.95 and he has faced 5,354 opposing hitters so far in his MLB career. Rodon (92-72 career win-loss record) has a 3.73 ERA while conceding 7.6 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take New York (-210)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here