Chicago White Sox vs Seattle Mariners Prediction, 8/6/2025 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Seattle Mariners

Date: Wednesday, August 6, 2025

Location: T-Mobile Park in Seattle, WA

TV: Root Sports Northwest

Odds/Point Spread: Chicago (+110) Seattle (-130)

The Chicago White Sox (42-70) are en route to T-Mobile Park on Wednesday where they will attempt to defeat the Seattle Mariners (60-53). The moneyline on this contest has Chicago at +110 while Seattle is sitting at -130. The total comes in at 9. The expected starting pitchers will be Jonathan Cannon and George Kirby.

Chicago has a slugging % of .367 and have been called out on strikes 931 times, while taking a walk on 354 occasions. They have earned 412 runs batted in and 847 base knocks on the campaign, while their batting average comes in at .230. The White Sox have recorded 175 doubles as a team and have smacked 104 balls out of the park. They have a total of 428 runs while having a team OBP of .300. As a squad, the Chicago White Sox are notching 3.8 runs per game, which puts them at 27th in MLB.

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The White Sox are sitting with a team earned run average of 4.08 for the year (17th in baseball), and their staff has rung up 832 batters. White Sox pitchers have relinquished 118 home runs and 491 total runs (18th in the league). They have walked 410 players from the other team and their FIP is 4.42 as a unit over the course of the season. Chicago has conceded 922 base hits (8.5 per 9 innings) in addition to 443 earned runs. They have accumulated a K/BB ratio of 2.03 and the pitching staff has a team WHIP of 1.36.

The White Sox relievers have a save rate of 46.9% and have entered the game in 80 save situations. The relief pitchers have inherited 152 base runners this season and 28.9% of them ended up crossing the plate. White Sox relief pitchers have entered the game with players on base 102 times as well as having 100 appearances in high leverage situations. The White Sox have dispatched 352 relief pitchers to the mound so far this season. The bullpen have 48 holds for the season (25th in MLB). They have recorded 15 saves this year and have missed out on 17 of their 32 chances to get a save.

The Chicago Cubs have accumulated 2,931 putouts this season, as well as 924 assists and 68 errors. Their fielding percentage sits at .983 which is 26th in professional baseball, and have a total of 95 double plays. The White Sox have transformed 69.8% of baseballs in play into outs in their 8,793 innings, ranking them 16th in baseball.

Cannon has thrown 218 frames and is sitting with 166 punch outs in his MLB career. Cannon (9-18 win-loss record in his career) holds a FIP of 4.55 and he has faced 938 opposing batters in the major leagues. His earned run average is 4.62 (112 earned runs allowed) and he has a career WHIP of 1.366. He has given up 226 hits (9.3 hits per 9 innings) and has 72 walks.

Seattle is sitting with 159 HRs so far this season to go along with 490 RBIs. They have hit 153 two-baggers, while walking 380 times as well as scoring 511 runs. The Seattle Mariners have compiled a team on-base percentage of .319 in addition to a team batting average of .243 for the season. The Mariners have a team slugging percentage of .410 and they tally 4.52 runs per outing (11th in MLB). They have struck out on 1,005 occasions (4th in the league) and have 940 hits.

The Mariners hold a team WHIP of 1.244 in addition to having a FIP of 4.02 as a staff so far this year. Their K/BB ratio comes in at 8.40 (953 strikeouts vs 342 free passes). They have a ranking of 20th in MLB as a pitching staff in total hits conceded with 932. They have conceded 127 homers and they relinquish 4.30 runs per 9 innings (16th in the league). The Seattle pitching staff have surrendered 489 runs on the year while holding an ERA of 3.84 (437 earned runs yielded).

With 106 save situations, the Mariners have tallied 60 holds and also 19 blown saves. Seattle has had relief pitchers take the mound in 46 save chances and they have recorded 27 saves. Their relief pitchers have taken the field 160 times in high leverage situations and also on 96 occasions with runners on. Seattle relievers have an inherited score rate of 25.2% out of 103 inherited runners. They are ranked 22nd in the league with a save rate of 58.7%, and they have sent 378 relievers to the mound so far this season.

In 9,222 innings on the diamond, the Mariners have earned a defensive efficiency of 70.6% (10th in professional baseball). The Seattle Mariners have turned 87 double plays and have a fielding percentage of .989 (4th in baseball). The Mariners have 963 assists, 45 errors and have earned 3,074 putouts on the campaign.

In his MLB career, Kirby has allowed 558 base hits while accumulating 558 K's in 583 innings pitched. He has allowed a total of 228 earned runs while holding a WHIP of 1.097 and being the owner of a FIP of 3.5. He has a K/BB ratio of 6.80 and he has faced 2,371 opposing hitters during his career. Kirby (41-31 career record) has earned a 3.52 ERA and has given up 8.6 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Seattle (-130)

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