Chicago White Sox vs Tampa Bay Rays Prediction, 7/21/2025 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Tampa Bay Rays

Date: Monday, July 21, 2025

Location: George M. Steinbrenner Field in Tampa, FL

TV: FanDuel Sports Network Sun

Odds/Point Spread: Chicago (+102) Tampa Bay (-122)

The Tampa Bay Rays (50-47) welcome the Chicago White Sox (32-65) at George M. Steinbrenner Field on Monday. The moneyline on this matchup has the White Sox at +102 and the Rays are coming in at -122. The betting total is set at 8.5. The starting pitchers will be Shane Smith and Shane Baz.

The White Sox have hit 146 two-baggers as a unit and have smacked 76 balls out of the stadium. Chicago has a slugging % of .344 and have been called out on strikes 830 times, while drawing a walk on 318 occasions. As a team, the Chicago White Sox are notching 3.4 runs/g, which has them at 28th in MLB. They have recorded 317 RBI's and 694 hits this season, and their average at the plate is .220. They have notched a total of 332 runs scored and hold an OBP of .294.

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Their strikeout to walk ratio sits at 1.97 and their pitching staff holds a collective WHIP of 1.38. White Sox pitchers have conceded 106 long balls and also 430 runs (22nd in baseball). Chicago has surrendered 810 base hits (8.6 per 9 innings) in addition to 389 earned runs. The White Sox have compiled a team ERA of 4.15 on the year (21st in MLB), and their staff has rung up 696 hitters. Their pitching staff has walked 354 opposing batters and their FIP comes in at 4.52 as a unit on the campaign.

The White Sox have sent 301 relievers to the hill over the course of the season. The bullpen pitchers have inherited 124 runners on the year with 28.2% of those players crossed home plate. They have earned 12 saves so far this season and have blown 16 of 28 save opportunities. The White Sox relievers have accumulated a save rate of 42.9% and stepped onto the hill in 70 save situations. The relievers have a total of 42 holds over the course of the season (27th in MLB). White Sox pitchers have stepped onto the hill with opponents on base 86 times and also have had 88 appearances in high leverage situations.

The Chicago Cubs have a total of 2,531 putouts at this point in the season, as well as 799 assists and 58 errors. Their fielding percentage is at .983 which puts them in 25th in pro baseball, and have accumulated 81 double plays. The White Sox have converted 69.9% of baseballs in play into outs in their 7,593 innings on the diamond, ranking them 17th in baseball.

Smith (3-7 record in his career) has a FIP of 4.22 while he has faced 377 opposing batters in the majors. He has surrendered 76 hits (7.9 hits per 9 innings) and has 37 free passes. His ERA is 4.28 (41 earned runs allowed) and he has a WHIP of 1.311. Smith has taken the mound for 86 innings and has earned 81 strikeouts so far in his career.

Tampa Bay has tallied 105 HRs for the season as well as 424 RBIs. They have put up 150 doubles, while taking a walk 282 times as well as putting up 449 runs. The Tampa Bay Rays have a team OBP of .320 as well as a batting average of .258 over the course of the season. The Rays have a team slugging percentage of .405 and they tally 4.63 runs per contest (9th in the league). They have been rung up on 800 occasions (15th in the league) and have totaled 845 hits.

The Tampa Bay pitching staff have conceded 388 runs this year while having a team ERA of 3.78 (362 earned runs relinquished). They have conceded 127 homers and they relinquish 4.05 runs per 9 innings (10th in MLB). The Rays have a team WHIP of 1.203 and have a FIP of 4.25 as a squad this year. Their strikeout to walk ratio comes in at 8.30 (799 strikeouts vs 275 bases on balls). They rank 10th in baseball as a staff in total hits relinquished with 762.

Sitting with 92 save situations, the Rays have earned 54 holds and also 16 blown saves. Tampa Bay has called on relievers to take the mound in 37 save chances and they have walked away with 21 saves. Their bullpen pitchers have stepped onto the mound 92 times in high leverage situations and also on 71 occasions with runners on. Tampa Bay bullpen pitchers hold an inherited score rate of 36.9% out of their 103 inherited base runners. They are ranked 24th in MLB holding a save rate of 56.8%, and they have dispatched 301 relief pitchers to the mound on the year.

The Tampa Bay Rays have turned 97 double plays and own a fielding percentage of .987 (12th in pro baseball). The Rays have accrued 887 assists, 46 errors and are sitting with 2,588 putouts for the season. In their 7,764 innings on the diamond, the Rays have a defensive efficiency of 71.4% (5th in pro baseball).

Baz (15-10 record in his career) is the owner of a 3.77 earned run average and has conceded 7.4 hits per 9 innings. He has a K/BB ratio of 2.84 and he has gone up against 943 batters during his career. He has given up 96 earned runs while holding a WHIP of 1.165 and being the owner of a FIP of 3.7. In his pro baseball career, Baz has surrendered 188 hits while he has tallied 224 K's in 229 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Tampa Bay (-122)

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