Chicago White Sox vs Washington Nationals Prediction, 9/26/2025 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Washington Nationals

Date: Friday, September 26, 2025

Location: Nationals Park in Washington, D.C.

TV: MASN

Odds/Point Spread: Chicago (+220) Washington (-275)

The Washington Nationals (65-94) will go up against the Chicago White Sox (58-100) at Nationals Park on Friday. The moneyline on this contest has Chicago at +220 while Washington is sitting at -275. The over/under has been set at 8.5. The expected starting pitchers are Yoendrys Gomez and Cade Cavalli.

The White Sox have earned 236 two-baggers as a team and have hit 157 balls out of the park. Chicago has a slugging percentage of .371 and have been rung up 1,326 times, while being walked on 490 occasions. As a unit, the Chicago White Sox are compiling 3.9 runs/g, which has them at 28th in MLB. They have 600 runs batted in as well as 1,213 base knocks over the course of the season, and their team batting average is .232. They have notched a total of 621 runs scored while having a team on-base percentage of .301.

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Their strikeout to walk ratio is 2.13 and the pitching staff has earned a collective WHIP of 1.37. White Sox pitchers have given up 180 home runs and also 722 runs in total (21st in baseball). Chicago has conceded 1,305 base hits (8.5 per 9 innings) in addition to 652 earned runs. The White Sox are sitting with a team earned run average of 4.25 on the campaign (21st in baseball), and the staff has rung up 1,242 hitters. Their pitching staff has walked 583 opposing batters and their FIP sits at 4.46 as a team for the season.

The White Sox bullpen have accumulated a save rate of 52.2% and have stepped onto the mound in 117 save situations. The relief pitchers have inherited 233 runners so far this season and 31.3% of those runners earned a run for their team. White Sox relief pitchers have stepped onto the hill with runners on 159 times as well as having 150 appearances in high leverage situations. The White Sox have dispatched 517 relief pitchers to the mound this year. The relief pitchers have accumulated 69 holds over the course of the season (28th in the league). They have recorded 24 saves for the season and have missed out on 22 of their 46 chances to get a save.

The White Sox have converted 69.6% of balls in play into outs in their 12,438 innings, which has them sitting 19th in MLB. The Chicago Cubs have earned a total of 4,146 putouts on the campaign, in addition to 1,244 assists and 98 errors. Their fielding percentage sits at .982 which ranks 28th in MLB, and they have turned 128 double plays.

Gomez has taken the ball for 69 frames and has accounted for 67 punch outs during his MLB career. His ERA is 4.68 (36 ER's allowed) and he has a WHIP of 1.414. He has surrendered 64 hits (8.3 hits per 9 innings) and has 34 free passes. Gomez (3-3 career win-loss record) is the owner of a FIP of 4.61 and he has gone up against 314 opposing hitters in the major leagues.

The Washington Nationals hold a team on-base percentage of .305 as well as a batting average of .242 this season. They have been called out on strikes on 1,315 instances (16th in MLB) and have recorded 1,290 base hits. Washington is sitting with 152 home runs over the course of the season and 642 runs batted in. The Nationals have a team slugging percentage of .387 and they are earning 4.23 runs per contest (20th in the league). They have notched 256 two-baggers, while taking a walk 438 times and putting up 672 runs.

The Washington pitching staff have given up 876 runs this season while holding a team ERA of 5.34 (828 earned runs conceded). They have given up 207 home runs and they surrender 5.65 runs per 9 innings (29th in the league). The Nationals hold a team WHIP of 1.446 with a FIP of 4.71 as a staff on the campaign. Their K/BB ratio comes in at 7.90 (1,218 strikeouts vs 560 free passes). They are sitting at 29th in the league as a staff in total hits conceded with 1,459.

Washington has called on relievers to step onto the hill in 55 save chances and they have earned 36 saves. They rank 9th in MLB with a save rate of 65.5%, and they have sent 569 relievers to the mound on the season. Their relief pitchers have come in 131 times in high leverage situations and on 163 occasions with runners on. Washington relievers have an inherited score percentage of 39.5% out of their 271 inherited runners. Sitting with 130 save situations, the Nationals have amassed 74 holds in addition to 19 blown saves.

The Washington Nationals have turned 130 double plays and hold a fielding percentage of .984 (23rd in MLB). The Nationals have accrued 1,376 assists, 90 errors and have notched a total of 4,189 putouts this year. In their 12,567 innings played, the Nationals have earned a efficiency on defense of 68.0% (29th in pro baseball).

So far in his career, Cavalli has allowed 56 base hits while earning 40 K's in 48 frames. Cavalli (3-2 career win-loss record) holds a 5.22 earned run average while allowing 10.4 hits per nine innings. He has allowed a total of 28 ER's while holding a WHIP of 1.491 and being the owner of a FIP of 5.1. He has a strikeout to walk ratio of 2.50 and he has faced 221 batters so far in his career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (+220)

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