Cincinnati Reds vs Arizona Diamondbacks Prediction, 8/22/2025 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs Arizona Diamondbacks

Date: Friday, August 22, 2025

Location: Chase Field in Phoenix, AZ

TV: DBACKS.TV

Odds/Point Spread: Cincinnati (-130) Arizona (+110)

The Arizona Diamondbacks (62-66) will compete against the Cincinnati Reds (67-61) at Chase Field on Friday. The moneyline on this contest has the Reds at -130 and the Diamondbacks are coming in at +110. The over/under has been set at 8.5. The starting pitchers will be Zack Littell and Ryne Nelson.

As a squad, the Cincinnati Reds are scoring 4.6 runs per game, which has them sitting at 11th in baseball. They have racked up 574 runs and hold an on-base percentage of .318. The Reds have hit 199 doubles as a team and have hit 126 baseballs out of the park. They have 541 runs batted in as well as 1,049 base knocks over the course of the season, while their team batting average is at .247. Cincinnati has a slugging rate of .392 and have struck out 1,090 times, while drawing a walk on 411 occasions.

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They have earned a strikeout to walk ratio of 2.64 and their pitching staff has recorded a WHIP of 1.24. Reds pitchers have surrendered 138 long balls and 522 runs (11th in the league). Cincinnati has surrendered 986 base hits (8.0 per 9 innings) and 471 earned runs. The Reds have an ERA of 3.80 over the course of the season (9th in MLB), and their staff has rung up 1,041 batters. They have walked 395 opposing players and their FIP is 4.05 as a squad on the season.

The Reds relievers have earned a save percentage of 63.8% and have entered the game in 131 save situations. The relief pitchers have inherited 173 base runners this season with 31.8% of those runners crossed the plate. Reds relief pitchers have stepped onto the hill with runners on 113 times in addition to having 124 appearances in high leverage situations. The Reds have sent 429 relief pitchers to the hill over the course of the season. The relief pitchers have earned 82 holds this season (6th in baseball). They have earned 30 saves so far this season and have blown 17 out of their 47 save opportunities.

The Chicago White Sox have a tally of 3,350 putouts so far this season, in addition to 977 assists and 68 errors. Their fielding rate sits at .985 which puts them in 21st in professional baseball, and have accumulated 80 double plays. The Reds have converted 71.1% of balls in play into outs out of 10,050 innings on the field, which has them sitting 5th in MLB.

Littell has taken the hill for 567 frames and has accounted for 469 K's so far in his MLB career. Littell (33-29 win-loss record in his career) is the owner of a FIP of 3.75 while he has gone up against 2,366 batters in the major leagues. His earned run average is 3.81 (240 earned runs allowed) and his WHIP is 1.224. He has allowed 567 base hits (9.0 hits per nine innings) with 127 walks.

Arizona has hit 176 home runs this season as well as 604 RBIs. They have recorded 220 doubles, while taking a walk 435 times as well as putting up 619 runs. The Arizona Diamondbacks have earned an OBP of .326 as well as a team batting average of .250 so far this year. The Diamondbacks have a team slugging percentage of .439 and they score 4.91 runs per outing (6th in MLB). They have struck out on 999 instances (21st in baseball) and have tallied 1,068 base hits.

The Diamondbacks have a team WHIP of 1.336 and are the owners of a FIP of 4.31 as a unit over the course of the season. Their K/BB ratio comes in at 8.10 (1,012 strikeouts against 392 walks). They are sitting at 26th in the league as a staff in total hits conceded with 1,103. They have allowed 156 home runs and they concede 4.95 runs per 9 innings (25th in the league). The Arizona pitching staff have given up 616 runs this season and come in with a team ERA of 4.57 (568 earned runs relinquished).

Arizona relief pitchers have an inherited score rate of 32.6% out of 132 inherited base runners. Their relief pitchers have taken the field 115 times in high leverage situations and on 103 occasions with runners on. Sitting with 123 save situations, the Diamondbacks have earned 62 holds and 24 blown saves. They are currently ranked 23rd in baseball holding a save percentage of 57.9%, and they have dispatched 381 relievers to the hill this season. Arizona has called on relief pitchers to enter the contest in 57 save chances and they have recorded 33 saves.

The Arizona Diamondbacks have gotten 96 double plays and have a fielding percentage of .986 (17th in professional baseball). The Diamondbacks have accrued 1,117 assists, 63 errors and have accumulated 3,357 putouts so far this year. Out of their 10,071 innings played, the Diamondbacks have accumulated a defensive efficiency of 69.1% (23rd in MLB).

Nelson (25-18 career win-loss record) has earned a 4.31 earned run average while surrendering 8.7 hits per nine innings. His strikeout to walk ratio is 2.91 and he has faced 1,776 batters thus far in his career. He has given up a total of 204 earned runs while holding a WHIP of 1.244 and a FIP of 4.2. During his pro baseball career, Nelson has given up 414 hits while accumulating 337 K's in 426 innings.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Arizona (+110) and under 8.5 runs

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