Cincinnati Reds vs Chicago Cubs Prediction, 8/6/2025 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs Chicago Cubs

Date: Wednesday, August 6, 2025

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: Cincinnati (+110) Chicago (-130)

The Chicago Cubs (65-47) will try to defeat the Cincinnati Reds (59-54) at Wrigley Field on Wednesday. The moneyline on this game has the Reds at +110 while the Cubs are priced at -130. The over/under is 9. The pitchers taking the mound will be Andrew Abbott and Cade Horton.

Cincinnati is slugging .392 and have been rung up 969 times, while taking a walk on 380 occasions. They have recorded 484 runs batted in and 934 hits this year, while their average at the plate is sitting at .247. The Reds have hit 175 two-baggers as a unit and have knocked 116 baseballs out of the stadium. They have accounted for 515 runs and hold an OBP of .320. As a unit, the Cincinnati Reds are notching 4.6 runs per outing, which has them at 10th in baseball.

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The Reds hold a team ERA of 3.87 on the season (13th in baseball), and the staff has rung up 940 batters. Reds pitchers have allowed 125 home runs in addition to 472 runs in total (14th in the league). Their pitching staff has walked 355 opposing hitters and their FIP comes in at 4.06 as a unit on the campaign. Cincinnati has given up 882 base knocks (7.9 per 9 innings) and also 430 earned runs. They have accrued a K/BB ratio of 2.65 and the pitching staff has recorded a WHIP of 1.24.

Reds pitchers have come into the game with players on base 95 times in addition to having 105 appearances in high leverage situations. The relievers have accumulated 72 holds over the course of the season (9th in the league). The Reds bullpen have compiled a save rate of 66.7% and stepped onto the hill in 116 save situations. They have accumulated 28 saves on the year and have not converted 14 out of their 42 chances to get a save. The relief pitchers have inherited 151 base runners this season with 34.4% of them earned a run for their team. The Reds have sent 386 relief pitchers to the mound on the season.

The Reds have transformed 71.1% of balls in play into outs in their 8,997 innings, which has them ranked 7th in pro baseball. The Chicago White Sox have a tally of 2,999 putouts over the course of the season, as well as 848 assists and 58 errors. Their fielding percentage is holding at .985 which is 19th in the majors, and have earned 68 double plays.

Abbott has thrown 355 frames and has earned 330 K's during his pro baseball career. Abbott (26-17 career win-loss record) holds a FIP of 3.24 while he has gone up against 1,487 batters during his time in the major leagues. His earned run average is 3.29 (130 earned runs allowed) and he has a career WHIP of 1.250. He has surrendered 315 base knocks (8.0 hits per nine innings) and has 129 walks.

The Chicago Cubs have an on-base percentage of .323 as well as a team batting average of .254 this season. They have been rung up on 875 occasions (26th in MLB) and have a total of 977 base hits. Chicago has tallied 160 HRs for the year and 566 RBIs. The Cubs have a team SLG% of .439 and they tally 5.19 runs per contest (1st in the league). They have put up 193 two-baggers, while getting a free base 380 times and racking up 581 runs.

The Chicago pitching staff have yielded 467 runs so far this season while having a team ERA of 3.91 (433 earned runs conceded). They have allowed 143 dingers and they relinquish 4.22 runs per 9 innings (12th in baseball). The Cubs have a WHIP of 1.224 and are the owners of a FIP of 4.28 as a staff this season. Their strikeout to walk ratio sits at 7.60 (842 strikeouts vs 295 walks). They are sitting at 17th in the league as a staff in total hits given up with 924.

Chicago relievers hold an inherited score rate of 31.5% out of their 108 inherited base runners. Their bullpen pitchers have stepped onto the mound 110 times in high leverage situations and on 77 occasions with runners on base. Sitting with 115 save situations, the Cubs have accumulated 73 holds in addition to 13 blown saves. They are ranked 6th in the league with a save rate of 66.7%, and they have dispatched 372 relievers to the mound over the course of the season. Chicago has had bullpen pitchers take the mound in 39 save opportunities and they have come away with 26 saves.

The Chicago Cubs have gotten 89 double plays and have a fielding percentage of .988 (6th in MLB). The Cubs have recorded 941 assists, 47 errors and have earned a total of 2,990 putouts for the year. Out of their 8,970 innings on the field, the Cubs have earned a defensive efficiency of 71.3% (4th in professional baseball).

So far in his MLB career, Horton has allowed 70 base knocks while he has totaled 53 K's in 73 innings. He has allowed 28 earned runs while earning a WHIP of 1.298 and having a FIP of 3.4. His K/BB ratio is 2.12 and he has faced 307 opposing hitters thus far in his career. Horton (5-3 mark in his career) has earned a 3.44 ERA while allowing 8.6 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Cincinnati (+110)

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