Cincinnati Reds vs Milwaukee Brewers Prediction, 9/27/2025 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs Milwaukee Brewers

Date: Saturday, September 27, 2025

Location: American Family Field in Milwaukee, WI

TV: FanDuel Sports Network Wisconsin

Odds/Point Spread: Cincinnati (+132) Milwaukee (-160)

American Family Field is where the Milwaukee Brewers (96-63) will take on the Cincinnati Reds (80-78) on Saturday. The line on this matchup has the Reds at +132 and the Brewers are coming in at -160. The betting total comes in at 8.5. The pitchers who are expected to start will be Andrew Abbott and Jacob Misiorowski.

The Reds have accounted for 244 doubles as a team and have hit 164 balls out of the park. Cincinnati is slugging .392 and have been called out on strikes 1,377 times, while taking a walk on 515 occasions. As a team, the Cincinnati Reds are notching 4.4 runs per outing, which has them at 14th in MLB. They have amassed 664 RBI's as well as 1,299 base knocks so far this season, and their batting average is .244. They have racked up 702 runs and hold an on-base percentage of .315.

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Their strikeout to walk ratio is 2.78 and their pitching staff has a team WHIP of 1.23. Reds pitchers have allowed 188 home runs and also 671 runs in total (12th in the league). Cincinnati has given up 1,240 base hits (8.0 per 9 innings) and also 606 earned runs. The Reds have compiled a team ERA of 3.90 for the season (14th in MLB), and they have struck out 1,338 hitters. They have walked 481 opposing hitters and their FIP is 4.14 as a squad this season.

The Reds have sent 535 relievers to the hill so far this year. The relief pitchers have inherited 213 runners this season and 32.4% of those players earned a run for their team. They have earned 38 saves so far this year and have blown 22 of their 60 chances to save the game. The Reds relief pitchers have accumulated a save rate of 63.3% and stepped onto the hill in 161 save situations. The bullpen are sitting with 98 holds this year (7th in the league). Reds bullpen pitchers have entered the contest with runners on base 145 times as well as having 166 appearances in high leverage situations.

The Reds have converted 71.0% of balls hit into play into outs in their 12,600 innings, which ranks them 4th in baseball. The Chicago White Sox have a tally of 4,200 putouts this season, as well as 1,215 assists and 85 errors. Their fielding rate sits at .985 which puts them in 22nd in pro baseball, and have accumulated 99 double plays.

Abbott has pitched in 408 innings and has accounted for 379 strikeouts thus far in his career. Abbott (27-23 career record) has earned a FIP of 3.35 while he has faced 1,708 opposing hitters in the major leagues. His earned run average is 3.40 (154 ER's allowed) and his WHIP is 1.247. He has given up 370 base knocks (8.2 hits per nine innings) with 139 free passes.

Milwaukee has recorded 164 home runs for the season and 741 RBIs. They have hit 258 doubles, while walking 552 times as well as scoring 797 runs. The Milwaukee Brewers have tallied an on-base percentage of .333 in addition to a batting average of .260 on the campaign. The Brewers have a team slugging % of .405 and they have an average of 5.01 runs per outing (3rd in the league). They have been rung up on 1,238 instances (26th in the league) and have tallied 1,406 hits.

The Milwaukee pitching staff have given up 622 runs for the year while holding a team ERA of 3.61 (568 earned runs given up). They have surrendered 165 homers and they give up 3.96 runs per 9 innings (3rd in the league). The Brewers hold a team WHIP of 1.227 in addition to having a FIP of 3.92 as a team on the year. Their strikeout to walk ratio comes in at 8.90 (1,402 strikeouts against 523 walks). They are sitting at 3rd in MLB as a pitching staff in total hits surrendered with 1,213.

Milwaukee bullpen pitchers hold an inherited score percentage of 30.7% out of their 212 inherited base runners. Their relief pitchers have stepped onto the mound 185 times in high leverage situations and also on 142 occasions with base runners. Sitting with 173 save situations, the Brewers have 104 holds in addition to 21 blown saves. They are currently ranked 6th in baseball with a save rate of 67.7%, and they have sent 538 relief pitchers to the hill for the season. Milwaukee has had bullpen pitchers enter the game in 65 save opportunities and they have tallied 44 saves.

In their 12,735 innings on the diamond, the Brewers have a defensive efficiency of 70.9% (5th in professional baseball). The Milwaukee Brewers have turned 119 double plays and have notched a fielding percentage of .987 (9th in pro baseball). The Brewers have recorded 1,277 assists, 73 errors and are sitting with 4,245 putouts for the year.

In his pro baseball career, Misiorowski has given up 48 hits and he has 84 strikeouts in 63 innings. Misiorowski (5-3 mark in his career) has earned a 4.41 earned run average and has surrendered 6.8 hits per 9 innings. He has given up a total of 31 earned runs while earning a WHIP of 1.203 and a FIP of 4.3. He has a K/BB ratio of 3.00 and he has faced 260 opposing batters during his career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Cincinnati (+132)

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