Cincinnati Reds vs Milwaukee Brewers Prediction, 9/28/2025 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs Milwaukee Brewers

Date: Sunday, September 28, 2025

Location: American Family Field in Milwaukee, WI

TV: FanDuel Sports Network Wisconsin

Odds/Point Spread: Cincinnati (+150) Milwaukee (-182)

The Cincinnati Reds (81-78) are on their way to American Family Field on Sunday where they will play the Milwaukee Brewers (96-63). The moneyline on this contest has the Reds at +150 and the Brewers open at -182. The total is 8. The pitchers taking the mound will be Brady Singer and Freddy Peralta.

The Reds have earned 245 doubles as a team and have hit 164 balls out of the park. Cincinnati has a slugging rate of .391 and have struck out 1,385 times, while drawing a walk on 516 occasions. As a unit, the Cincinnati Reds are earning 4.4 runs per game, which has them sitting at 15th in the league. They have accumulated 666 RBI's as well as 1,309 base knocks this season, while their batting average comes in at .245. They have tallied 704 runs scored while holding a team on-base percentage of .315.

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The Reds have a team earned run average of 3.88 on the campaign (12th in the league), and their staff has struck out 1,352 hitters. Reds pitchers have relinquished 188 long balls in addition to 672 runs in total (12th in baseball). They have walked 482 players from the other team and their FIP comes in at 4.12 as a unit on the season. Cincinnati has given up 1,243 hits (7.9 per 9 innings) and 607 earned runs. Their K/BB ratio is 2.80 and their pitching staff has recorded a WHIP of 1.22.

The Reds relief pitchers have accumulated a save rate of 63.9% and have entered the game in 164 save situations. The relief pitchers have inherited 213 base runners on the year with 32.4% of them earned a run for their team. Reds bullpen pitchers have come into the game with runners on base 145 times as well as having 168 appearances in high leverage situations. The Reds have sent 538 relievers to the hill on the season. The bullpen have tallied 100 holds for the season (7th in MLB). They have 39 saves over the course of the season and have blown 22 out of their 61 chances to save the game.

The Reds have converted 71.1% of balls in play into outs out of their 12,681 innings on the field, ranking them 4th in professional baseball. The Chicago White Sox have a tally of 4,227 putouts thus far, in addition to 1,220 assists and 85 errors. Their fielding percentage is holding steady at .985 which has them ranked 22nd in pro baseball, and they have turned 99 double plays.

Singer has taken the hill for 851 frames and is sitting with 803 strikeouts during his MLB career. His earned run average is 4.22 (399 earned runs allowed) and his WHIP is 1.308. He has given up 840 base knocks (8.9 hits per 9 innings) with 273 walks. Singer (50-55 career win-loss mark) sits with a FIP of 4.16 while facing 3,632 hitters during his time in the majors.

The Milwaukee Brewers have a team OBP of .333 in addition to a team batting average of .260 for the year. They have been rung up on 1,238 occasions (26th in MLB) and are sitting with 1,406 base knocks. Milwaukee has hit 164 home runs so far this year to go along with 741 RBIs. The Brewers hold a team slugging percentage of .405 and they tally 5.01 runs per game (3rd in MLB). They have tallied 258 doubles, while taking a walk 552 times and putting up 797 runs.

The Brewers have a team WHIP of 1.227 with a FIP of 3.92 as a pitching staff this season. Their strikeout to walk ratio is 8.90 (1,402 strikeouts against 523 walks). They come in at 3rd in MLB as a pitching staff in total hits relinquished with 1,213. They have allowed 165 long balls and they concede 3.96 runs per 9 innings (3rd in MLB). The Milwaukee pitching staff have conceded 622 runs on the season while having a team ERA of 3.61 (568 earned runs yielded).

Milwaukee has called on relief pitchers to take the mound in 65 save chances and they have converted 44 saves. They rank 6th in the league with a save rate of 67.7%, and they have dispatched 538 relief pitchers onto the field this season. Their relievers have stepped onto the mound 185 times in high leverage situations in addition to 142 occasions with runners on. Milwaukee relief pitchers hold an inherited score percentage of 30.7% out of 212 inherited base runners. Sitting with 173 save situations, the Brewers have amassed 104 holds and 21 blown saves.

In 12,735 innings on the diamond, the Brewers have earned a defensive efficiency of 70.9% (5th in professional baseball). The Milwaukee Brewers have turned 119 double plays and hold a fielding percentage of .987 (9th in MLB). The Brewers have accrued 1,277 assists, 73 errors and have notched a total of 4,245 putouts during this campaign.

In his MLB career, Peralta has conceded 691 hits while he has accumulated 1,150 punch outs in 928 innings pitched. Peralta (70-42 career record) has earned a 3.59 ERA and has allowed 6.7 hits per 9 innings. He has surrendered a total of 370 earned runs while holding a WHIP of 1.132 and a FIP of 3.5. He has a K/BB ratio of 3.19 and he has gone up against 3,844 opposing hitters thus far in his career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Cincinnati (+150)

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