Cincinnati Reds vs San Diego Padres Prediction, 9/8/2025 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs San Diego Padres

Date: Monday, September 8, 2025

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: Cincinnati (+125) San Diego (-150)

Petco Park is where the San Diego Padres (76-64) will meet the Cincinnati Reds (70-70) on Monday. The odds on this game have the Reds at +125 while the Padres are priced at -150. The total is set at 8. The men taking the mound will be Nick Lodolo and Yu Darvish.

The Reds have earned 229 doubles as a unit and have hit 138 balls out of the park. Cincinnati has a slugging percentage of .393 and have struck out 1,216 times, while taking a walk on 456 occasions. As a unit, the Cincinnati Reds are notching 4.5 runs per game, which ranks them 13th in the league. They have 598 RBI's and 1,173 hits for the year, while their batting average comes in at .248. They have 634 runs while holding a team on-base percentage of .318.

Get all of our MLB Expert Picks

They have accrued a K/BB ratio of 2.71 and their pitching staff holds a collective WHIP of 1.25. Reds pitchers have allowed 166 home runs and 607 runs in total (16th in MLB). Cincinnati has surrendered 1,111 base hits (8.1 per 9 innings) and 544 earned runs. The Reds have compiled a team ERA of 3.95 on the campaign (15th in MLB), and the staff has rung up 1,186 hitters. They have walked 438 opposing players and their FIP is 4.16 as a unit so far this year.

Reds relief pitchers have stepped onto the hill with runners on base 127 times in addition to having 142 appearances in high leverage situations. The bullpen have earned 88 holds this season (7th in MLB). The Reds relief pitchers have earned a save rate of 61.5% and have entered the game in 142 save situations. They have tallied 32 saves for the year and have blown 20 of their 52 save opportunities. The bullpen pitchers have inherited 189 base runners so far this season and 32.8% of them earned a run for their team. The Reds have sent 481 relief pitchers to the hill for the year.

The Chicago White Sox have earned a total of 3,719 putouts this season, in addition to 1,059 assists and 80 errors. Their fielding percentage sits at .984 which has them sitting 26th in MLB, and they have turned 90 double plays. The Reds have turned 70.7% of baseballs in play into outs in their 11,157 innings, which has them ranked 8th in the majors.

Lodolo (23-21 career win-loss mark) sits with a FIP of 4.01 while he has gone up against 1,647 batters in the major leagues. He has conceded 356 base knocks (8.3 hits per nine innings) and has had 111 walks. His earned run average is 4.07 (175 ER's allowed) and his career WHIP is 1.206. Lodolo has taken the hill for 387 frames and has racked up 430 strikeouts during his career.

The San Diego Padres have recorded an OBP of .322 in addition to a team batting average of .252 on the year. They have been called out on strikes on 987 instances (28th in MLB) and have 1,177 base hits. San Diego has 122 home runs so far this season as well as 556 RBIs. The Padres have a team SLG% of .385 and they score 4.23 runs per outing (23rd in MLB). They have 227 doubles, while taking a walk 451 times as well as earning 592 runs.

The Padres have a team WHIP of 1.210 and have a FIP of 4.01 as a squad on the campaign. Their strikeout to walk ratio comes in at 8.80 (1,207 strikeouts against 464 free passes). They rank 1st in baseball as a staff in total hits relinquished with 1,032. They have surrendered 148 homers and they give up 3.96 runs per 9 innings (3rd in baseball). The San Diego pitching staff have yielded 544 runs on the campaign while having an ERA of 3.66 (503 earned runs yielded).

San Diego relief pitchers have an inherited score percentage of 29.1% out of 230 inherited base runners. Their bullpen pitchers have taken the field 186 times in high leverage situations and on 161 occasions with runners on. With 153 save situations, the Padres have 90 holds in addition to 15 blown saves. They rank 1st in the league with a save rate of 74.1%, and they have dispatched 496 relievers onto the diamond on the campaign. San Diego has called on relief pitchers to enter the game in 58 save chances and they have walked away with 43 saves.

The San Diego Padres have gotten 100 double plays and have notched a fielding percentage of .987 (11th in MLB). The Padres have accrued 1,055 assists, 64 errors and have earned 3,708 putouts so far this season. In 11,124 innings on the diamond, the Padres have accumulated a efficiency on defense of 71.8% (2nd in professional baseball).

In his career, Darvish has conceded 1,438 base hits while accumulating 2,055 strikeouts in 1,757 innings pitched. Darvish (113-93 record in his career) has a 3.64 ERA while surrendering 7.4 hits per 9 innings. He has surrendered 711 earned runs while earning a WHIP of 1.138 and a FIP of 3.6. He has a strikeout to walk ratio of 3.66 and he has faced 7,223 opposing hitters thus far in his career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Cincinnati (+125)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here