Cincinnati Reds vs St. Louis Cardinals Prediction, 6/21/2025 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs St. Louis Cardinals

Date: Saturday, June 21, 2025

Location: Busch Stadium in St. Louis, MO

TV: FanDuel Sports Network Midwest

Odds/Point Spread: Cincinnati (-196) St. Louis (+162)

Busch Stadium is where the St. Louis Cardinals (38-35) will play the Cincinnati Reds (39-35) on Saturday. The odds on this game have the Reds at -196 while the Cardinals are opening at +162. The over/under has been set at 9. The pitchers taking the mound will be Wade Miley and Andre Pallante.

As a unit, the Cincinnati Reds are putting up 4.7 runs per game, which ranks them 8th in baseball. They have accumulated 345 runs scored while having a team OBP of .323. The Reds have hit 123 doubles as a team and have hit 83 baseballs out of the park. They have accrued 332 RBI's and 615 base knocks this season, while their batting average comes in at .248. Cincinnati is slugging .404 and have been rung up 643 times, while being walked on 259 occasions.

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The Reds are sitting with a team ERA of 3.80 for the year (13th in MLB), and their staff has rung up 586 batters. Reds pitchers have allowed 87 long balls in addition to 301 runs in total (16th in MLB). They have walked 221 opposing hitters and their FIP sits at 4.16 as a squad so far this season. Cincinnati has allowed 562 hits (7.8 per 9 innings) and 275 earned runs. They have earned a K/BB ratio of 2.65 and the pitching staff has earned a collective WHIP of 1.20.

Reds relief pitchers have gone to the mound with players on base 48 times as well as having 65 appearances in high leverage situations. The bullpen have accumulated 47 holds on the campaign (9th in baseball). The Reds relief pitchers have recorded a save percentage of 71.4% and have come into the game in 77 save situations. They have earned 20 saves so far this year and have blown 8 of their 28 chances to get a save. The relievers have inherited 77 base runners for the season and 33.8% of those players crossed the plate. The Reds have dispatched 242 relievers to the hill so far this season.

The Reds have transformed 72.3% of balls hit into play into outs out of 5,868 innings, which ranks them 2nd in the majors. The Chicago White Sox have 1,956 putouts on the campaign, in addition to 569 assists and 35 errors. Their fielding percentage sits at .986 which has them sitting 16th in professional baseball, and have a total of 45 double plays.

Miley (109-99 win-loss record in his career) is the owner of a FIP of 4.03 while he has faced 7,519 batters during his time in the major leagues. He has given up 1,783 base knocks (9.1 hits per 9 innings) and has 611 free passes. His earned run average is 4.09 (798 earned runs allowed) and his WHIP is 1.362. Miley has taken the mound for 1,757 innings and has accounted for 1,368 strikeouts in his pro baseball career.

The Cardinals have a team slugging % of .393 and they are earning 4.66 runs per game (9th in MLB). They have recorded 127 two-baggers, while walking 233 times as well as earning 340 runs. St. Louis has tallied 68 home runs so far this year to go along with 322 runs batted in. They have been rung up on 567 occasions (25th in the league) and have recorded 637 hits. The St. Louis Cardinals have tallied a team on-base percentage of .328 as well as a team batting average of .257 this year.

The Cardinals have a WHIP of 1.274 and are the owners of a FIP of 3.65 as a squad this season. Their K/BB ratio is 7.30 (521 strikeouts against 194 walks). They come in at 21st in the league as a pitching staff in total hits conceded with 629. They have conceded 59 homers and they surrender 4.35 runs per 9 innings (19th in MLB). The St. Louis pitching staff have allowed 312 runs for the year while having a team ERA of 3.97 (285 earned runs surrendered).

St. Louis relievers have an inherited score percentage of 36.2% of 94 inherited runners. Their bullpen pitchers have come in 82 times in high leverage situations in addition to 72 occasions with runners on. Sitting with 75 save situations, the Cardinals have 44 holds and 11 blown saves. They are ranked 20th in the league with a save percentage of 60.7%, and they have dispatched 217 bullpen pitchers onto the diamond for the season. St. Louis has had relief pitchers enter the contest in 28 save opportunities and they have tallied 17 saves.

The St. Louis Cardinals have turned 54 double plays and have a fielding rate of .990 (2nd in professional baseball). The Cardinals have recorded 707 assists, 27 errors and have amassed 1,940 putouts during this campaign. Out of their 5,820 innings played, the Cardinals hold a efficiency on defense of 69.6% (19th in MLB).

So far in his pro baseball career, Pallante has surrendered 378 base hits while he has earned 264 K's in 373 innings pitched. He has allowed 166 ER's while earning a WHIP of 1.399 and being the owner of a FIP of 3.9. His K/BB ratio is 1.83 and he has gone up against 1,599 hitters so far in his MLB career. Pallante (22-17 record in his career) has a 4.00 earned run average and has given up 9.1 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take St. Louis (+162) and under 9 runs

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