Cincinnati Reds vs St. Louis Cardinals Prediction, 6/22/2025 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs St. Louis Cardinals

Date: Sunday, June 22, 2025

Location: Busch Stadium in St. Louis, MO

TV: FanDuel Sports Network Midwest

Odds/Point Spread: Cincinnati (+106) St. Louis (-128)

The Cincinnati Reds (39-36) are on their way to Busch Stadium on Sunday where they will play the St. Louis Cardinals (40-35). The odds on this game have Cincinnati at +106 while St. Louis is coming in at -128. The over/under comes in at 8. The starting pitchers will be Andrew Abbott and Miles Mikolas.

The Reds have tallied 125 two-baggers as a unit and have hit 84 balls out of the stadium. Cincinnati is slugging .404 and have been rung up 653 times, while being walked on 260 occasions. As a squad, the Cincinnati Reds are compiling 4.7 runs per outing, which is 8th in baseball. They have accumulated 337 RBI's and 625 base knocks over the course of the season, and their batting average is at .248. They have tallied 350 runs scored and hold an OBP of .322.

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The Reds have a team earned run average of 3.91 for the season (17th in baseball), and the staff has rung up 596 hitters. Reds pitchers have surrendered 91 home runs and also 313 runs (16th in MLB). Their pitching staff has walked 229 opposing players and their FIP is 4.23 as a unit on the campaign. Cincinnati has relinquished 579 base hits (7.9 per 9 innings) and also 287 earned runs. Their strikeout to walk ratio sits at 2.60 and their pitching staff has a collective WHIP of 1.22.

The Reds have dispatched 247 relief pitchers to the mound this year. The relief pitchers have inherited 83 runners this season and 31.3% of those runners crossed home plate. They have recorded 20 saves so far this season and have blown 8 out of their 28 save opportunities. The Reds relievers have a save percentage of 71.4% and have come into the game in 77 save situations. The bullpen have racked up 47 holds on the campaign (10th in MLB). Reds bullpen pitchers have stepped onto the hill with runners on 52 times in addition to having 65 appearances in high leverage situations.

The Chicago White Sox have 1,983 putouts on the year, in addition to 575 assists and 35 errors. Their fielding rate is currently at .987 which has them sitting 15th in the majors, and have a total of 45 double plays. The Reds have converted 72.1% of baseballs in play into outs out of their 5,949 innings, which has them sitting at 2nd in pro baseball.

Abbott has taken the ball for 315 innings and has racked up 303 strikeouts so far in his pro baseball career. His earned run average is 3.37 (118 earned runs allowed) and his WHIP is 1.244. He has allowed 276 hits (7.9 hits per nine innings) with 116 free passes. Abbott (24-17 career record) holds a FIP of 3.32 while he has faced 1,316 hitters in the major leagues.

The Cardinals hold a slugging percentage of .396 and they tally 4.71 runs per game (7th in the league). They have notched 130 doubles, while getting a free base 241 times as well as racking up 353 runs. St. Louis has recorded 72 home runs so far this season to go along with 335 RBIs. They have been rung up on 589 occasions (20th in the league) and have notched a total of 657 hits. The St. Louis Cardinals have tallied an on-base percentage of .328 in addition to a batting average of .257 for the year.

The St. Louis pitching staff have given up 322 runs on the year while holding an ERA of 3.98 (294 earned runs yielded). They have conceded 62 home runs and they allow 4.36 runs per 9 innings (19th in MLB). The Cardinals have a team WHIP of 1.275 with a FIP of 3.66 as a pitching staff on the year. Their strikeout to walk ratio is 7.30 (540 strikeouts against 202 bases on balls). They come in at 24th in the league as a staff in total hits given up with 646.

Sitting with 78 save situations, the Cardinals have earned 45 holds and 11 blown saves. St. Louis has had bullpen pitchers step onto the hill in 30 save chances and they have tallied 19 saves. Their relief pitchers have stepped onto the mound 86 times in high leverage situations and on 75 occasions with base runners. St. Louis relievers hold an inherited score percentage of 36.7% out of their 98 inherited base runners. They sit at 15th in baseball holding a save percentage of 63.3%, and they have sent 226 relief pitchers onto the diamond this season.

In their 5,991 innings on the field, the Cardinals have a defensive efficiency of 69.7% (18th in pro baseball). The St. Louis Cardinals have turned 55 double plays and have a fielding percentage of .990 (2nd in the majors). The Cardinals have racked up 726 assists, 28 errors and have 1,997 putouts this season.

Mikolas (68-68 career record) is the owner of a 4.17 earned run average and has conceded 9.1 hits per 9 innings. His K/BB ratio is 3.70 and he has gone up against 4,857 batters thus far in his career. He has given up a total of 541 ER's while earning a WHIP of 1.208 and having a FIP of 4.1. During his MLB career, Mikolas has surrendered 1,184 hits while he has totaled 840 punch outs in 1,168 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take St. Louis (-128) and under 8 runs

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