Cincinnati Reds vs St. Louis Cardinals Prediction, 9/15/2025 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs St. Louis Cardinals

Date: Monday, September 15, 2025

Location: Busch Stadium in St. Louis, MO

TV: FanDuel Sports Network Midwest

Odds/Point Spread: Cincinnati (-275) St. Louis (+220)

The Cincinnati Reds (74-72) are on their way to Busch Stadium on Monday where they will attempt to beat the St. Louis Cardinals (72-75). The moneyline on this game has Cincinnati at -275 while St. Louis is at +220. The total is set at 9. The pitchers expected to start will be Zack Littell and Matthew Liberatore.

Cincinnati is slugging .391 and have been called out on strikes 1,275 times, while being walked on 477 occasions. They have 620 runs batted in in addition to 1,211 base knocks so far this season, while their team batting average sits at .246. The Reds have compiled 233 doubles as a unit and have hit 146 baseballs out of the park. They have notched a total of 656 runs scored while holding a team OBP of .316. As a team, the Cincinnati Reds are knocking in 4.5 runs/g, which has them sitting at 13th in MLB.

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The Reds have an ERA of 3.91 so far this season (14th in MLB), and their staff has rung up 1,239 batters. Reds pitchers have surrendered 171 home runs and also 624 runs in total (14th in MLB). Their pitching staff has walked 455 opposing batters and their FIP is 4.13 as a unit so far this year. Cincinnati has conceded 1,148 hits (8.0 per 9 innings) in addition to 562 earned runs. They have a K/BB ratio of 2.72 and their pitching staff holds a collective WHIP of 1.24.

The Reds have dispatched 499 relievers to the hill this year. The relievers have inherited 193 runners for the season with 33.2% of those players ended up crossing the plate. They have accumulated 35 saves on the campaign and have blown 21 of their 56 chances to save the game. The Reds bullpen have recorded a save percentage of 62.5% and have stepped onto the mound in 149 save situations. The relievers have a total of 91 holds so far this season (7th in baseball). Reds relief pitchers have entered the game with runners on 130 times in addition to having 154 appearances in high leverage situations.

The Chicago White Sox have amassed 3,882 putouts on the campaign, as well as 1,108 assists and 82 errors. Their fielding percentage is holding at .984 which is 25th in professional baseball, and have accumulated 93 double plays. The Reds have turned 70.9% of balls hit into play into outs in their 11,646 innings on the field, ranking them 5th in the majors.

Littell (33-29 career win-loss mark) is the owner of a FIP of 3.82 while he has gone up against 2,453 opposing batters in the major leagues. He has conceded 586 base hits (9.0 hits per nine innings) and has 132 free passes. His earned run average is 3.88 (253 earned runs allowed) and he has a WHIP of 1.223. Littell has taken the ball for 587 innings and has accounted for 486 punch outs so far in his MLB career.

The Cardinals have a SLG% of .379 and they are earning 4.28 runs per contest (22nd in baseball). They have recorded 234 two-baggers, while walking 433 times as well as putting up 629 runs. St. Louis has accumulated 138 HRs on the season as well as 599 runs batted in. They have been rung up on 1,185 occasions (22nd in MLB) and have earned 1,206 base hits. The St. Louis Cardinals have accumulated a team OBP of .313 as well as a team batting average of .244 on the season.

The St. Louis pitching staff have given up 675 runs on the year while holding a team ERA of 4.26 (615 earned runs given up). They have conceded 151 homers and they relinquish 4.67 runs per 9 innings (20th in MLB). The Cardinals hold a team WHIP of 1.314 in addition to having a FIP of 4.04 as a pitching staff for the year. Their strikeout to walk ratio sits at 7.50 (1,086 strikeouts vs 415 walks). They come in at 26th in MLB as a staff in total hits conceded with 1,293.

St. Louis has had relief pitchers step onto the mound in 58 save opportunities and they have come away with 38 saves. They are ranked 9th in the league with a save rate of 65.5%, and they have sent 434 bullpen pitchers onto the field over the course of the season. Their relief pitchers have come in 140 times in high leverage situations and on 141 occasions with runners on base. St. Louis bullpen pitchers hold an inherited score rate of 32.8% out of their 195 inherited base runners. With 143 save situations, the Cardinals have earned 82 holds in addition to 20 blown saves.

Out of their 11,706 innings on the field, the Cardinals are sitting with a efficiency on defense of 69.1% (21st in professional baseball). The St. Louis Cardinals have turned 116 double plays and have a fielding percentage of .987 (11th in baseball). The Cardinals have accrued 1,414 assists, 71 errors and have earned 3,902 putouts so far this year.

During his MLB career, Liberatore has surrendered 338 base hits while he has totaled 260 strikeouts in 322 innings pitched. Liberatore (15-24 career win-loss mark) holds a 4.72 earned run average and has surrendered 9.4 hits per 9 innings. He has given up 169 ER's while earning a WHIP of 1.387 and having a FIP of 4.6. He has a K/BB ratio of 2.39 and he has gone up against 1,399 hitters so far in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take St. Louis (+220)

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