Cincinnati Reds vs St. Louis Cardinals Prediction, 9/17/2025 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs St. Louis Cardinals

Date: Wednesday, September 17, 2025

Location: Busch Stadium in St. Louis, MO

TV: FanDuel Sports Network Midwest

Odds/Point Spread: Cincinnati (-275) St. Louis (+220)

The Cincinnati Reds (75-75) are en route to Busch Stadium on Wednesday where they will play the St. Louis Cardinals (73-78). The line on this matchup has Cincinnati at -275 and St. Louis is opening at +220. The total has been set at 9. The starting pitchers are Brady Singer and Andre Pallante.

Cincinnati has a slugging percentage of .392 and have been rung up 1,303 times, while taking a walk on 494 occasions. They have accounted for 639 runs batted in as well as 1,245 hits on the year, while their batting average is at .246. The Reds have recorded 236 two-baggers as a team and have hit 152 baseballs out of the stadium. They have 676 runs scored and hold an on-base percentage of .317. As a team, the Cincinnati Reds are scoring 4.5 runs per outing, which has them sitting at 13th in baseball.

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Their K/BB ratio is 2.73 and the pitching staff has earned a collective WHIP of 1.24. Reds pitchers have allowed 181 home runs and 651 runs in total (15th in baseball). Cincinnati has surrendered 1,186 base knocks (8.0 per 9 innings) and 589 earned runs. The Reds are sitting with a team ERA of 3.99 over the course of the season (15th in the league), and their staff has struck out 1,267 hitters. Their pitching staff has walked 464 opposing players and their FIP sits at 4.20 as a squad for the season.

Reds pitchers have come into the game with runners on 137 times and also have had 158 appearances in high leverage situations. The relief pitchers have a total of 91 holds over the course of the season (9th in baseball). The Reds relief pitchers have accumulated a save percentage of 61.4% and stepped onto the hill in 151 save situations. They have accumulated 35 saves for the year and have blown 22 of their 57 save opportunities. The relief pitchers have inherited 205 runners over the course of the season with 33.7% of those runners ended up crossing the plate. The Reds have sent 511 relief pitchers to the mound over the course of the season.

The Chicago White Sox have 3,981 putouts at this point in the season, in addition to 1,152 assists and 83 errors. Their fielding percentage sits at .984 which is 22nd in MLB, and have a total of 95 double plays. The Reds have transformed 70.9% of balls in play into outs out of their 11,943 innings, which has them sitting at 4th in pro baseball.

Singer (49-54 career win-loss record) is the owner of a FIP of 4.16 while he has faced 3,587 opposing batters during his time in the majors. He has given up 830 base hits (8.9 hits per nine innings) and has 271 walks. His earned run average is 4.22 (394 ER's allowed) and his career WHIP is 1.310. Singer has taken the hill for 840 innings and has 794 K's in his career.

The St. Louis Cardinals have accounted for a team on-base percentage of .314 in addition to a team batting average of .245 on the season. They have been called out on strikes on 1,220 occasions (21st in baseball) and have accounted for 1,243 hits. St. Louis is sitting with 140 home runs on the season and 616 runs batted in. The Cardinals hold a team SLG% of .378 and they average 4.29 runs per contest (18th in baseball). They have tallied 241 two-baggers, while getting a free base 446 times as well as scoring 648 runs.

The Cardinals hold a team WHIP of 1.323 and have a FIP of 4.05 as a pitching staff over the course of the season. They are currently ranked 27th in the league as a staff in total hits given up with 1,336. The St. Louis pitching staff have allowed 705 runs so far this year and come in with a team ERA of 4.32 (641 earned runs surrendered). They currently have a strikeout to walk ratio of 7.50 (1,117 strikeouts against 432 free passes). They have allowed 155 homers and they concede 4.75 runs per 9 innings (22nd in baseball).

St. Louis has called on relievers to take the mound in 61 save opportunities and they have walked away with 39 saves. They are ranked 11th in baseball with a save rate of 63.9%, and they have sent 450 relievers to the hill this year. Their bullpen pitchers have stepped onto the hill 148 times in high leverage situations and on 148 occasions with runners on base. St. Louis bullpen pitchers hold an inherited score percentage of 33.0% out of their 206 inherited base runners. Sitting with 150 save situations, the Cardinals have compiled 85 holds and 22 blown saves.

In 12,024 innings played, the Cardinals have accumulated a defensive efficiency of 69.0% (22nd in professional baseball). The St. Louis Cardinals have turned 119 double plays and have notched a fielding percentage of .987 (12th in the majors). The Cardinals have 1,447 assists, 74 errors and have amassed 4,008 putouts so far this season.

Pallante (24-28 career record) has earned a 4.32 ERA and has given up 9.2 hits per 9 innings. He has a K/BB ratio of 1.79 and he has faced 1,945 batters during his career. He has conceded 217 earned runs while earning a WHIP of 1.413 and a FIP of 4.3. During his career, Pallante has allowed 464 base hits while he has totaled 314 punch outs in 452 frames.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Cincinnati (-275)

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