Cleveland Guardians vs Boston Red Sox Prediction, 9/1/2025 MLB Picks, Best Bets & Odds

Game: Cleveland Guardians vs Boston Red Sox

Date: Monday, September 1, 2025

Location: Fenway Park in Boston, MA

TV: NESN

Odds/Point Spread: Cleveland (+110) Boston (-130)

Fenway Park is the location where the Boston Red Sox (75-60) will try to beat the Cleveland Guardians (66-66) on Monday. The moneyline on this matchup has the Guardians at +110 and the Red Sox open at -130. The betting total is set at 8. The pitchers who are expected to start are Slade Cecconi and Brayan Bello.

As a team, the Cleveland Guardians are recording 3.9 runs per contest, which has them sitting at 28th in baseball. They have 508 runs scored while holding a team OBP of .295. The Guardians have tallied 189 two-baggers as a squad and have knocked 133 baseballs out of the park. They have amassed 489 RBI's and 966 hits on the year, and their batting average is sitting at .224. Cleveland is slugging .366 and have been called out on strikes 1,093 times, while drawing a walk on 407 occasions.

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Their K/BB ratio is 2.38 and the pitching staff has a team WHIP of 1.31. Guardians pitchers have conceded 145 long balls and also 563 runs in total (14th in MLB). Cleveland has allowed 1,077 hits (8.3 per 9 innings) as well as 512 earned runs. The Guardians have an earned run average of 3.93 this year (13th in MLB), and they have rung up 1,099 batters. Their pitching staff has walked 461 players from the other team and their FIP comes in at 4.14 as a team for the year.

The Guardians have dispatched 441 relievers to the mound so far this season. The relievers have inherited 170 runners on the campaign with 33.5% of those players ended up crossing the plate. They have recorded 38 saves over the course of the season and have missed out on 18 out of their 56 chances to save the game. The Guardians relief pitchers have accumulated a save percentage of 67.9% and have stepped onto the mound in 150 save situations. The relief pitchers are sitting with 91 holds so far this season (3rd in the league). Guardians relief pitchers have come into the game with runners on base 122 times and also have had 153 appearances in high leverage situations.

The Guardians have transformed 69.6% of balls hit into play into outs out of their 10,566 innings on the diamond, ranking them 19th in professional baseball. The Cincinnati Reds have a tally of 3,522 putouts thus far, as well as 1,076 assists and 86 errors. Their fielding rate is holding steady at .982 which has them ranked 28th in baseball, and they have turned 95 double plays.

Cecconi has taken the mound for 206 innings and has racked up 167 strikeouts thus far in his career. Cecconi (7-14 mark in his career) is the owner of a FIP of 5.16 and he has gone up against 879 hitters during his time in the major leagues. His earned run average is 5.24 (120 earned runs allowed) and his WHIP is 1.306. He has allowed 222 base knocks (9.7 hits per nine innings) with 47 free passes.

The Boston Red Sox are sitting with a team OBP of .323 and a team batting average of .252 for the season. They have been called out on strikes on 1,192 occasions (4th in baseball) and have totaled 1,167 hits. Boston has a total of 163 home runs on the season to go along with 638 RBIs. The Red Sox have a team SLG% of .425 and they tally 4.95 runs per game (5th in MLB). They have recorded 271 two-baggers, while getting a free base 441 times as well as scoring 668 runs.

The Boston pitching staff have surrendered 560 runs over the course of the season while having an ERA of 3.66 (491 earned runs allowed). They have allowed 137 homers and they relinquish 4.17 runs per 9 innings (9th in MLB). The Red Sox are sitting with a team WHIP of 1.279 and have a FIP of 4.00 as a unit this year. Their K/BB ratio is 8.30 (1,116 strikeouts against 439 walks). They have a ranking of 17th in MLB as a staff in total hits allowed with 1,107.

With 135 save situations, the Red Sox have earned 72 holds and also 23 blown saves. Boston has had bullpen pitchers enter the game in 61 save opportunities and they have converted 38 saves. Their relievers have stepped onto the hill 165 times in high leverage situations and on 134 occasions with runners on. Boston relievers have an inherited score rate of 30.9% out of their 178 inherited base runners. They are currently ranked 19th in the league holding a save percentage of 62.3%, and they have dispatched 439 relievers to the mound for the year.

In 10,800 innings played, the Red Sox have accumulated a defensive efficiency of 69.3% (21st in professional baseball). The Boston Red Sox have turned 107 double plays and have accounted for a fielding rate of .980 (29th in baseball). The Red Sox have recorded 1,228 assists, 101 errors and are sitting with 3,600 putouts over the course of the season.

In his career, Bello has given up 521 hits while he has earned 448 strikeouts in 517 innings pitched. Bello (38-33 career record) has a 4.04 earned run average while giving up 9.1 hits per nine innings. He has allowed 232 ER's while holding a WHIP of 1.361 and being the owner of a FIP of 4.0. He has a K/BB ratio of 2.45 and he has faced 2,226 opposing hitters in his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Cleveland (+110)

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